| IED ID |
IndEnz0002016444 |
| Enzyme Type ID |
protease016444 |
| Protein Name |
Caspase
EC 3.4.22.-
drICE
Cleaved into: Caspase subunit p21; Caspase subunit p12
|
| Gene Name |
Drice ICE CG7788 |
| Organism |
Drosophila melanogaster (Fruit fly) |
| Taxonomic Lineage |
cellular organisms
Eukaryota
Opisthokonta
Metazoa
Eumetazoa
Bilateria
Protostomia
Ecdysozoa
Panarthropoda
Arthropoda
Mandibulata
Pancrustacea
Hexapoda
Insecta
Dicondylia
Pterygota (winged insects)
Neoptera
Endopterygota
Diptera
Brachycera
Muscomorpha
Eremoneura
Cyclorrhapha
Schizophora
Acalyptratae
Ephydroidea
Drosophilidae (pomace flies)
Drosophilinae
Drosophilini
Drosophila (fruit flies)
Sophophora
melanogaster group
melanogaster subgroup
Drosophila melanogaster (Fruit fly)
|
| Enzyme Sequence |
MDATNNGESADQVGIRVGNPEQPNDHTDALGSVGSGGAGSSGLVAGSSHPYGSGAIGQLANGYSSPSSSYRKNVAKMVTDRHAAEYNMRHKNRGMALIFNHEHFEVPTLKSRAGTNVDCENLTRVLKQLDFEVTVYKDCRYKDILRTIEYAASQNHSDSDCILVAILSHGEMGYIYAKDTQYKLDNIWSFFTANHCPSLAGKPKLFFIQACQGDRLDGGVTMQRSQTETDGDSSMSYKIPVHADFLIAYSTVPGFYSWRNTTRGSWFMQSLCAELAANGKRLDILTLLTFVCQRVAVDFESCTPDTPEMHQQKQIPCITTMLTRILRFSDKQLAPAGRV |
| Enzyme Length |
339 |
| Uniprot Accession Number |
O01382 |
| Absorption |
|
| Active Site |
ACT_SITE 169; /evidence=ECO:0000250; ACT_SITE 211; /evidence=ECO:0000250 |
| Activity Regulation |
|
| Binding Site |
|
| Calcium Binding |
|
| catalytic Activity |
|
| DNA Binding |
|
| EC Number |
3.4.22.- |
| Enzyme Function |
FUNCTION: Involved in the activation cascade of caspases responsible for apoptosis execution. Acts downstream of rpr. Cleaves baculovirus p35 and lamin DmO in vitro. |
| Temperature Dependency |
|
| PH Dependency |
|
| Pathway |
|
| nucleotide Binding |
|
| Features |
Active site (2); Beta strand (9); Chain (2); Helix (9); Mutagenesis (2); Propeptide (2); Region (1); Sequence conflict (2); Turn (3) |
| Keywords |
3D-structure;Apoptosis;Hydrolase;Protease;Reference proteome;Thiol protease;Zymogen |
| Interact With |
Q9XYF4 |
| Induction |
|
| Subcellular Location |
|
| Modified Residue |
|
| Post Translational Modification |
|
| Signal Peptide |
|
| Structure 3D |
X-ray crystallography (2) |
| Cross Reference PDB |
3SIP;
3SIR;
|
| Mapped Pubmed ID |
10074440;
10077606;
10407412;
10481910;
10511707;
10521468;
10559939;
10559952;
10580984;
10619022;
10619023;
10704400;
10733594;
10777599;
10825159;
10908589;
11042680;
11048731;
11139272;
11139274;
11139276;
11139278;
11165519;
11178240;
11337486;
11562344;
11742098;
11901173;
11997504;
12006672;
12011068;
12021767;
12070100;
12072176;
12202036;
12397080;
12421711;
12473344;
12478468;
12547518;
12593803;
12636917;
12692559;
12695332;
12725740;
12729588;
12729918;
12737795;
12737804;
12783893;
12809598;
12814564;
12885559;
12906812;
12917412;
12935877;
12938178;
13678953;
14502294;
14561774;
14576353;
14603309;
14605208;
14644196;
14645122;
14647296;
14654021;
14657035;
14668412;
14706701;
14737191;
14976192;
14996492;
15066287;
15082313;
15107838;
15150408;
15211354;
15337122;
15342479;
15342648;
15355784;
15383617;
15522457;
15533997;
15572132;
15573123;
15580265;
15640802;
15657059;
15710747;
15800001;
15827086;
15860727;
16099837;
16111679;
16222340;
16273080;
16280349;
16314564;
16322754;
16326394;
16355253;
16359857;
16362035;
16485033;
16530179;
16645642;
16774996;
16785441;
16797177;
16887831;
16906130;
16929521;
16980627;
17014842;
17027478;
17068333;
17090721;
17134692;
17205079;
17227774;
17275304;
17341581;
17347664;
17449640;
17464325;
17557079;
17573067;
17582002;
17612403;
17636001;
17682052;
17728345;
17880263;
17937502;
17989181;
18084239;
18259196;
18309328;
18331718;
18664581;
18701548;
18779587;
18794330;
18820459;
18940735;
19013449;
19026784;
19182545;
19217892;
19224859;
19232093;
19237508;
19330035;
19465595;
19483676;
19497884;
19737742;
19750210;
19818615;
19838331;
19960024;
20080168;
20176975;
20220848;
20371351;
20445064;
20617381;
20627310;
20659495;
20700104;
20935466;
21035895;
21074052;
21113144;
21120926;
21136153;
21145488;
21220123;
21338340;
21338343;
21482673;
21653668;
21811237;
21949352;
22100313;
22153373;
22351928;
22367497;
22479597;
22539005;
22555454;
22935612;
23018595;
23028118;
23071443;
23087837;
23161111;
23222440;
23306653;
23519152;
23523076;
23561633;
23784845;
23791523;
23810935;
23846225;
23878397;
23913920;
23940367;
23943356;
24036278;
24239163;
24302569;
24316411;
24333635;
24336022;
24385865;
24553922;
24632609;
24819984;
24862573;
24891502;
24967585;
25036253;
25096240;
25146930;
25217223;
25255315;
25579975;
25644603;
25668151;
25798905;
25855961;
25894556;
25951229;
25963257;
25970035;
26010168;
26021298;
26022392;
26069889;
26134911;
26173873;
26291171;
26362609;
26374522;
26413413;
26526100;
26542461;
26546607;
26900934;
26960254;
27177021;
27256879;
27322327;
27518434;
27558818;
27575697;
27773719;
27923046;
27999411;
28085885;
28401354;
28455414;
28524858;
28529177;
28631994;
28688927;
28751499;
28806103;
28808034;
28853394;
28870988;
28900135;
28928435;
29033939;
29231806;
29385168;
29447906;
29571611;
29750169;
29765111;
29787709;
29854765;
30022065;
30159848;
30413561;
30563404;
30833576;
30836847;
30919912;
31068592;
31255773;
31287057;
31409797;
31438818;
31548372;
31566767;
31641960;
31673827;
31722958;
31745213;
31794428;
31822470;
32658991;
32658993;
32707222;
32796885;
32845992;
33063715;
33135280;
33184261;
33300258;
33377870;
33547995;
33561221;
33802079;
33820625;
33863891;
33920158;
34379632;
34463269;
9196327;
9321398;
9862464;
9874786;
9916984;
9990849;
|
| Motif |
|
| Gene Encoded By |
|
| Mass |
37,363 |
| Kinetics |
|
| Metal Binding |
|
| Rhea ID |
|
| Cross Reference Brenda |
|