IED ID |
IndEnz0002016448 |
Enzyme Type ID |
protease016448 |
Protein Name |
Caspase Dronc
EC 3.4.22.-
NEDD2-like caspase
Cleaved into: Caspase Nc subunit 1; Caspase Nc subunit 2
|
Gene Name |
Dronc Nc CG8091 |
Organism |
Drosophila melanogaster (Fruit fly) |
Taxonomic Lineage |
cellular organisms
Eukaryota
Opisthokonta
Metazoa
Eumetazoa
Bilateria
Protostomia
Ecdysozoa
Panarthropoda
Arthropoda
Mandibulata
Pancrustacea
Hexapoda
Insecta
Dicondylia
Pterygota (winged insects)
Neoptera
Endopterygota
Diptera
Brachycera
Muscomorpha
Eremoneura
Cyclorrhapha
Schizophora
Acalyptratae
Ephydroidea
Drosophilidae (pomace flies)
Drosophilinae
Drosophilini
Drosophila (fruit flies)
Sophophora
melanogaster group
melanogaster subgroup
Drosophila melanogaster (Fruit fly)
|
Enzyme Sequence |
MQPPELEIGMPKRHREHIRKNLNILVEWTNYERLAMECVQQGILTVQMLRNTQDLNGKPFNMDEKDVRVEQHRRLLLKITQRGPTAYNLLINALRNINCLDAAVLLESVDESDSRPPFISLNERRTSRKSADIVDTPSPEASEGPCVSKLRNEPLGALTPYVGVVDGPEVKKSKKIHGGDSAILGTYKMQSRFNRGVLLMVNIMDYPDQNRRRIGAEKDSKSLIHLFQELNFTIFPYGNVNQDQFFKLLTMVTSSSYVQNTECFVMVLMTHGNSVEGKEKVEFCDGSVVDMQKIKDHFQTAKCPYLVNKPKVLMFPFCRGDEYDLGHPKNQGNLMEPVYTAQEEKWPDTQTEGIPSPSTNVPSLADTLVCYANTPGYVTHRDLDTGSWYIQKFCQVMADHAHDTDLEDILKKTSEAVGNKRTKKGSMQTGAYDNLGFNKKLYFNPGFFNE |
Enzyme Length |
450 |
Uniprot Accession Number |
Q9XYF4 |
Absorption |
|
Active Site |
ACT_SITE 271; /evidence=ECO:0000250|UniProtKB:P29466; ACT_SITE 318; /evidence=ECO:0000250|UniProtKB:P29466 |
Activity Regulation |
|
Binding Site |
|
Calcium Binding |
|
catalytic Activity |
|
DNA Binding |
|
EC Number |
3.4.22.- |
Enzyme Function |
FUNCTION: Involved in the activation cascade of caspases responsible for apoptosis execution. Effector of steroid-mediated apoptosis during insect metamorphosis. Overexpression promotes programmed cell death. Interaction with Diap1 is required to suppress Dronc-mediated cell death; via Diap1-mediated ubiquitination of Dronc. Rate-limiting caspase in rpr and hid death pathway. {ECO:0000269|PubMed:10200258, ECO:0000269|PubMed:10675329, ECO:0000269|PubMed:10984473, ECO:0000269|PubMed:14517550}. |
Temperature Dependency |
|
PH Dependency |
|
Pathway |
|
nucleotide Binding |
|
Features |
Active site (2); Beta strand (10); Chain (2); Domain (1); Helix (7); Mutagenesis (1); Propeptide (2); Region (1); Turn (3) |
Keywords |
3D-structure;Apoptosis;Cytoplasm;Hydrolase;Protease;Reference proteome;Thiol protease;Ubl conjugation;Zymogen |
Interact With |
Q7KLI1; Q24306; O01382 |
Induction |
INDUCTION: By ecdysone; exposure of salivary glands and midgut isolated from second instar larvae results in a massive increase in levels. {ECO:0000269|PubMed:10200258}. |
Subcellular Location |
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. |
Modified Residue |
|
Post Translational Modification |
PTM: Ubiquitinated by Diap1, leading to its subsequent degradation. {ECO:0000269|PubMed:12021771}. |
Signal Peptide |
|
Structure 3D |
Electron microscopy (1); X-ray crystallography (2) |
Cross Reference PDB |
1Q4Q;
2FP3;
3J9K;
|
Mapped Pubmed ID |
10481910;
10511707;
10559952;
10619023;
10639136;
10684245;
10704400;
10764741;
10825159;
10908589;
10934188;
10983989;
11048731;
11102824;
11139272;
11139274;
11139276;
11139278;
11139280;
11165519;
11178240;
11237461;
11262243;
11287192;
11337486;
11494315;
11550090;
11901173;
11997504;
12006672;
12011068;
12021767;
12021769;
12045184;
12065414;
12070100;
12072176;
12084706;
12095613;
12110175;
12176339;
12297099;
12356728;
12397080;
12441239;
12453466;
12473344;
12478468;
12502734;
12547518;
12593803;
12593804;
12692559;
12725740;
12729588;
12737795;
12737804;
12783893;
12814564;
12850443;
12852852;
12853472;
12906812;
12938178;
12970673;
1450511;
14532134;
14576353;
14644196;
14647296;
14657035;
14668412;
14724249;
14737191;
14744432;
14764878;
14976192;
14980217;
14996492;
15082313;
15107838;
15173191;
15239946;
15242648;
15268856;
15337122;
15355784;
15383617;
15469838;
15522457;
15533997;
15572131;
15572132;
15573123;
15640802;
15657059;
15704171;
15710747;
15774476;
15776001;
15782175;
15800001;
15860727;
15900708;
15922568;
15970694;
16222340;
16224045;
16303568;
16314564;
16322754;
16324723;
16362035;
16446367;
16456582;
16485033;
16528381;
16533943;
16595176;
16612543;
16645642;
16672345;
16797177;
16816412;
16880123;
16887178;
16887350;
16887831;
16890515;
16901779;
16906130;
16920621;
16954388;
16980627;
16980964;
17000765;
17027478;
17068333;
17183368;
17183370;
17205079;
17256009;
17275304;
17310982;
17339382;
17341581;
17347664;
17464325;
17522156;
17522160;
17557079;
17582002;
17591924;
17612403;
17636001;
17679695;
17682052;
17728345;
17937502;
17988176;
17989181;
17998402;
18039869;
18045837;
18083103;
18084239;
18309328;
18331718;
18367553;
18455715;
18506601;
18695041;
18794330;
19011620;
19026784;
19064709;
19077536;
19084594;
19100727;
19182545;
19214204;
19217892;
19224859;
19244279;
19330035;
19364807;
19375319;
19428445;
19465595;
19483676;
19497884;
19498442;
19720858;
19737742;
19744473;
19818615;
19822670;
19855017;
19874832;
19960024;
19960025;
20014406;
20016284;
20023159;
20023160;
20063412;
20100334;
20122400;
20127699;
20220848;
20445064;
20478529;
20624856;
20627310;
20679206;
20682638;
20700104;
20882681;
20951343;
21035895;
21074052;
21113144;
21120926;
21136153;
21179433;
21220123;
21338340;
21338343;
21343367;
21385866;
21425087;
21471375;
21558368;
21811237;
21844890;
21886178;
21886179;
21909282;
21958154;
22036477;
22065747;
22095281;
22153373;
22238688;
22351928;
22367497;
22393355;
22479597;
22539005;
22555454;
22898807;
22900232;
22981648;
23018595;
23028118;
23071443;
23087837;
23184991;
23209440;
23222440;
23264732;
23306653;
23336071;
23408884;
23447678;
23519152;
23523076;
23561633;
23644660;
23722427;
23743202;
23754750;
23784845;
23810935;
23913920;
23940367;
23943356;
23951408;
23968895;
24023255;
24036278;
24066226;
24096487;
24239163;
24316411;
24333635;
24336022;
24362437;
24374353;
24492611;
24497843;
24553922;
24598157;
24643212;
24685612;
24746817;
24793180;
24819984;
24865556;
24891502;
24907259;
24967585;
24981286;
25012819;
25015062;
25036253;
25146930;
25171415;
25217223;
25255315;
25312911;
25329560;
25332163;
25398939;
25579975;
25613379;
25644603;
25668151;
25790850;
25855961;
25868821;
25933381;
25951229;
25963257;
25968311;
25968339;
26010168;
26021298;
26034307;
26069889;
26134911;
26160069;
26255846;
26291171;
26362609;
26374522;
26413413;
26647185;
26896675;
26898463;
26900934;
26912791;
26960254;
26972874;
27058168;
27104928;
27172210;
27177021;
27256879;
27308545;
27351747;
27518434;
27537218;
27558818;
27575697;
27773719;
27923046;
27999411;
28045022;
28068320;
28077877;
28207763;
28211869;
28401354;
28430154;
28455414;
28492538;
28514643;
28524858;
28619822;
28631994;
28683272;
28688927;
28751499;
28853394;
28870988;
28893998;
28900135;
28928435;
28935711;
28945745;
29033939;
29050293;
29084807;
29108021;
29372681;
29385168;
29431244;
29447906;
29576455;
29670104;
29750169;
29764857;
29765111;
29787709;
29854765;
29870691;
29970915;
30022065;
30036358;
30080872;
30159848;
30413561;
30462636;
30563404;
30741974;
30770378;
30796611;
30836847;
30855229;
30872455;
30901919;
30904193;
30912203;
30919912;
31068592;
31136986;
31231648;
31255773;
31409797;
31438818;
31548372;
31566767;
31641108;
31722958;
31745213;
31772150;
31822470;
31909714;
32053595;
32157127;
32174999;
32287290;
32658991;
32658993;
32686670;
32698005;
32707222;
32791328;
32796885;
32845992;
32894223;
33022230;
33063715;
33075096;
33135280;
33184261;
33238125;
33309868;
33377870;
33507966;
33514791;
33561221;
33662357;
33802079;
33863891;
33920158;
33983927;
34081909;
34120097;
34313318;
34349099;
34463269;
|
Motif |
|
Gene Encoded By |
|
Mass |
51,141 |
Kinetics |
|
Metal Binding |
|
Rhea ID |
|
Cross Reference Brenda |
|