| IED ID | IndEnz0002016461 |
| Enzyme Type ID | protease016461 |
| Protein Name |
Cys-Gly metallodipeptidase DUG1 EC 3.4.13.- Deficient in utilization of glutathione protein 1 GSH degradosomal complex subunit DUG1 |
| Gene Name | DUG1 CAALFM_C504300CA CaO19.11397 CaO19.3915 |
| Organism | Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Saccharomycotina (true yeasts) Saccharomycetes Saccharomycetales Debaryomycetaceae Candida/Lodderomyces clade Candida Candida albicans (Yeast) Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) |
| Enzyme Sequence | MSTSTTYEKLPLQPLFDTIEELKPKFIERLQKAIAIPSVSSDESLRPKVVEMANFLVDELKTLGFTDIQLKELGTQPPPVQDANLQLPPIVLGRFGNDPAKKTVLVYGHYDVQPALKDDGWKTEPFTMHYDKEKEILYGRGSTDDKGPVVGWLNVIEAHNKLGWELPVNLVVCFEGMEESGSLGLDELVAKEAQNYFKKVDQVTISDNYWLGTTKPVLTYGLRGCNYYQIIIEGPGADLHSGIFGGIIAEPMTDLIKVMSTLVDGSGKILIPGVYDMVAPLTDKEDQLYDSIDFSVEELNAASGSQTSLHDNKKDILKHRWRFPSLSLHGIEGAFSGAGAKTVIPAKVVGKFSIRTVPDIESKKLDDLVFQHITSEFKKLNSPNKFKVELIHDGNYWVSDPFNDSFTAAAKATQDVWNVVPDFTREGGSIPITLTFEKELGVDVLLLPMGRGDDGAHSINEKLDVSNYINGCKTLGGYLHYYGKA |
| Enzyme Length | 485 |
| Uniprot Accession Number | Q5AKA5 |
| Absorption | |
| Active Site | ACT_SITE 111; /evidence=ECO:0000250; ACT_SITE 178; /note=Proton acceptor; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.13.- |
| Enzyme Function | FUNCTION: Catalytic component of the GSH degradosomal complex involved in the degradation of glutathione (GSH) and other peptides containing a gamma-glu-X bond. Functions also as a dipeptidase with high specificity for Cys-Gly and no activity toward tri- or tetrapeptides (By similarity). {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Chain (1); Erroneous initiation (1); Metal binding (6) |
| Keywords | Cytoplasm;Dipeptidase;Hydrolase;Manganese;Metal-binding;Metalloprotease;Phosphoprotein;Protease;Reference proteome;Zinc |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 53,675 |
| Kinetics | |
| Metal Binding | METAL 109; /note=Zinc 2; /evidence=ECO:0000250; METAL 144; /note=Zinc 1; /evidence=ECO:0000250; METAL 144; /note=Zinc 2; /evidence=ECO:0000250; METAL 179; /note=Zinc 1; /evidence=ECO:0000250; METAL 207; /note=Zinc 2; /evidence=ECO:0000250; METAL 457; /note=Zinc 1; /evidence=ECO:0000250 |
| Rhea ID | |
| Cross Reference Brenda |