| IED ID | IndEnz0002016465 |
| Enzyme Type ID | protease016465 |
| Protein Name |
Extracellular matrix protein 1 Secretory component p85 |
| Gene Name | ECM1 |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MGTTARAALVLTYLAVASAASEGGFTATGQRQLRPEHFQEVGYAAPPSPPLSRSLPMDHPDSSQHGPPFEGQSQVQPPPSQEATPLQQEKLLPAQLPAEKEVGPPLPQEAVPLQKELPSLQHPNEQKEGTPAPFGDQSHPEPESWNAAQHCQQDRSQGGWGHRLDGFPPGRPSPDNLNQICLPNRQHVVYGPWNLPQSSYSHLTRQGETLNFLEIGYSRCCHCRSHTNRLECAKLVWEEAMSRFCEAEFSVKTRPHWCCTRQGEARFSCFQEEAPQPHYQLRACPSHQPDISSGLELPFPPGVPTLDNIKNICHLRRFRSVPRNLPATDPLQRELLALIQLEREFQRCCRQGNNHTCTWKAWEDTLDKYCDREYAVKTHHHLCCRHPPSPTRDECFARRAPYPNYDRDILTIDIGRVTPNLMGHLCGNQRVLTKHKHIPGLIHNMTARCCDLPFPEQACCAEEEKLTFINDLCGPRRNIWRDPALCCYLSPGDEQVNCFNINYLRNVALVSGDTENAKGQGEQGSTGGTNISSTSEPKEE |
| Enzyme Length | 540 |
| Uniprot Accession Number | Q16610 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Involved in endochondral bone formation as negative regulator of bone mineralization. Stimulates the proliferation of endothelial cells and promotes angiogenesis. Inhibits MMP9 proteolytic activity. {ECO:0000269|PubMed:11165938, ECO:0000269|PubMed:11292659, ECO:0000269|PubMed:16512877}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Alternative sequence (6); Chain (1); Compositional bias (3); Glycosylation (3); Natural variant (5); Region (4); Repeat (2); Sequence conflict (2); Signal peptide (1) |
| Keywords | Alternative splicing;Angiogenesis;Biomineralization;Disease variant;Extracellular matrix;Glycoprotein;Mineral balance;Osteogenesis;Reference proteome;Repeat;Secreted;Signal |
| Interact With | Q9NQ94; Q08043; O75934; Q9NX04; A8MQ03; Q86UW9; Q9H0I2; P48023; O75344; O43559; O75603; Q9Y223-2; O95872; P28799; P31273; P16144-2; Q2WGJ6; Q6L8H2; Q9BYQ3; Q5TA79; O14910; P61968; Q13064; P31323; Q96NU1; Q96EQ0; P09234; Q9UMX0; Q9UHD9 |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..19; /evidence=ECO:0000250|UniProtKB:Q62894 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 1435334; 14550953; 16274456; 16646403; 16713569; 17721643; 17927570; 18200062; 18438406; 18443958; 19068216; 19219685; 19230975; 19519837; 19521735; 19734986; 19861958; 20014019; 20711500; 20805453; 20870722; 21128013; 21349189; 21791056; 21988832; 22489696; 23534907; 23602568; 23696932; 24023917; 24079542; 24259048; 24413997; 24708644; 24779890; 25446258; 25517360; 25518807; 25529926; 25746001; 25812648; 25824756; 26564090; 26738999; 26826312; 27133046; 27241643; 27316685; 27460906; 27770373; 28493612; 28699600; 29059156; 29718750; 29729708; 29858602; 30165197; 30789914; 31319137; 32203150; 33046330; 33910591; 34244494; |
| Motif | |
| Gene Encoded By | |
| Mass | 60,674 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |