| IED ID |
IndEnz0002016499 |
| Enzyme Type ID |
protease016499 |
| Protein Name |
Cystatin cpi-2
|
| Gene Name |
cpi-2 |
| Organism |
Brugia malayi (Filarial nematode worm) |
| Taxonomic Lineage |
cellular organisms
Eukaryota
Opisthokonta
Metazoa
Eumetazoa
Bilateria
Protostomia
Ecdysozoa
Nematoda (roundworms)
Chromadorea
Rhabditida
Spirurina
Spiruromorpha
Filarioidea
Onchocercidae
Brugia
Brugia malayi (Filarial nematode worm)
|
| Enzyme Sequence |
MMSTMSIKEGLLVILLSLFLFDTTALIHRREIPHMESKGQMQRGQVLLGGWQERSPEDNEILELLPSVLTKVNQQSNDEYHLMPIKLLNVSSQVVAGVKYKMEVQVARSECKKSASEQVNLKTCKKLEGHPDQVMTLEVWEKPWEDFLQVNILETKVLSSV |
| Enzyme Length |
161 |
| Uniprot Accession Number |
A0A0K0IP23 |
| Absorption |
|
| Active Site |
|
| Activity Regulation |
|
| Binding Site |
|
| Calcium Binding |
|
| catalytic Activity |
|
| DNA Binding |
|
| EC Number |
|
| Enzyme Function |
FUNCTION: Cysteine protease inhibitor which inhibits members of the peptidase C1 family. Also acts as an asparaginyl endopeptidase inhibitor (PubMed:11301256, PubMed:15664654). In the human host, inhibits CTSL/cathepsin L, CTSS/cathepsin S, CTSB/cathepsin B and asparaginyl endopeptidase LGMN/AEP which may cause defects in both antigen and MHC class II invariant chain CD74/Ii processing (PubMed:11301256). {ECO:0000269|PubMed:11301256, ECO:0000269|PubMed:15664654}. |
| Temperature Dependency |
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| PH Dependency |
|
| Pathway |
|
| nucleotide Binding |
|
| Features |
Chain (1); Disulfide bond (1); Glycosylation (1); Motif (2); Mutagenesis (2); Sequence conflict (2); Signal peptide (1); Site (1) |
| Keywords |
Disulfide bond;Glycoprotein;Protease inhibitor;Reference proteome;Signal;Thiol protease inhibitor |
| Interact With |
|
| Induction |
|
| Subcellular Location |
|
| Modified Residue |
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| Post Translational Modification |
|
| Signal Peptide |
SIGNAL 1..25; /evidence=ECO:0000255 |
| Structure 3D |
|
| Cross Reference PDB |
- |
| Mapped Pubmed ID |
- |
| Motif |
MOTIF 76..78; /note=Important for interaction with host LGMN; /evidence=ECO:0000305|PubMed:15664654; MOTIF 93..97; /note=Secondary area of contact; /evidence=ECO:0000305 |
| Gene Encoded By |
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| Mass |
18,392 |
| Kinetics |
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| Metal Binding |
|
| Rhea ID |
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| Cross Reference Brenda |
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