| IED ID | IndEnz0002016528 |
| Enzyme Type ID | protease016528 |
| Protein Name |
Angiotensin-converting enzyme EC 3.4.15.1 Dipeptidyl carboxypeptidase I Kininase II |
| Gene Name | ACE |
| Organism | Haematobia irritans exigua (Buffalo fly) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Panarthropoda Arthropoda Mandibulata Pancrustacea Hexapoda Insecta Dicondylia Pterygota (winged insects) Neoptera Endopterygota Diptera Brachycera Muscomorpha Eremoneura Cyclorrhapha Schizophora Calyptratae Muscoidea Muscidae (house flies) Muscinae Stomoxyini Haematobia Haematobia irritans (Horn fly) (Conops irritans) Haematobia irritans exigua (Buffalo fly) |
| Enzyme Sequence | MKLLVVTILAGLAVCHGATKEEIVATEYLQNINKELAKHTNVETEVSWAYASNITDENERLRNEISAENAKFLKEVAKDIQKFNWRTYGSADVRRQFKSLSKTGYSALPAEDYAELLEVLSAMESNFAKVRVCDYKNSAKCDLSLDPEIEEIITKSRDPEELKYYWTQFYDKAGTPTRSNFEKYVELNTKSAKLNNFTDGAEVWLDEYEDATFEDQLEAIFEDIKPLYDQVHGYVRYRLNKFYGDEVVSKTGPLPMHLLGNMWAQQWSSIADIVSPFPEKPLVDVSDEMVAQGYTPLKMFQMGDDFFQSMGLKKLPQEFWDKSILEKPDDGRDLVCHASAWDFYLTDDVRIKQCTRVTQDQFFTVHHEMGHIQYFLQYQHQPFVYRTGANPGFHEAVGDVLSLSVSTPKHLERVGLLKNYVSDNEARINQLFLTALDKIVFLPFAFTMDKYRWALFRGQADKSEWNCAFWKLREEYSGIEPPVVRTEKDFDAPAKYHVSADVEYLRYLVSFIIQFQFYKSACITAGEYVPNQTEYPLDNCDIYGSKEAGKLFENMLSLGASKPWPDALEAFNGERTMTGKAIAEYFEPLRVWLEAVAVESLCHQRYKNVDL |
| Enzyme Length | 611 |
| Uniprot Accession Number | Q10715 |
| Absorption | |
| Active Site | ACT_SITE 368; /evidence=ECO:0000255|PROSITE-ProRule:PRU10095 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Release of a C-terminal dipeptide, oligopeptide-|-Xaa-Yaa, when Xaa is not Pro, and Yaa is neither Asp nor Glu. Thus, conversion of angiotensin I to angiotensin II, with increase in vasoconstrictor activity, but no action on angiotensin II.; EC=3.4.15.1; |
| DNA Binding | |
| EC Number | 3.4.15.1 |
| Enzyme Function | FUNCTION: Involved in the specific maturation or degradation of a number of bioactive peptides. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (1); Chain (1); Glycosylation (3); Metal binding (2); Signal peptide (1) |
| Keywords | Carboxypeptidase;Glycoprotein;Hydrolase;Metal-binding;Metalloprotease;Protease;Secreted;Signal;Zinc |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted, extracellular space {ECO:0000305}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..17; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 70,506 |
| Kinetics | |
| Metal Binding | METAL 367; /note=Zinc; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU10095; METAL 371; /note=Zinc; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU10095 |
| Rhea ID | |
| Cross Reference Brenda |