| IED ID | IndEnz0002016529 |
| Enzyme Type ID | protease016529 |
| Protein Name |
Angiotensin-converting enzyme EC 3.4.15.1 Dipeptidyl carboxypeptidase I Kininase II TtACE |
| Gene Name | ACE |
| Organism | Theromyzon tessulatum (Duck leech) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Spiralia Lophotrochozoa Annelida Clitellata Hirudinea (leeches) Rhynchobdellida Glossiphoniidae Theromyzon Theromyzon tessulatum (Duck leech) |
| Enzyme Sequence | MNLINFSYLNLLFGAGLFSVLESATILNTESDAKKWLTTYNDEAGKYIYDATEAEWNYNTNLTDHNLGISIKKSNDLATFTEQKAIEANKKFVWKNFTDPLLKREFSKITDIGTASLSDEDFQKMSGLNSDLTKIYSTAKVCNKPNDPSGKCYPLDPDLSDIISKSNDLEELTWAWKGWRDASGKHMPDKYDEFVQLLNKAANINGYEDNGDYWRSWYESPTFRKDCEDLWQEIKPFYEQLHAYVRRKLQKKYPQIAFPKEGHIPAHLLGNMWAQSWENIEYLLRPAPDLPSMDITEELVKQNYTALKLFQLSDTFFKSLGLIQMPQPFWEKSMIEKPADRDVVCHASAWDFYNRKDFRIKQCTVVDMHWFMTTHHEMGHIEYYLHYKDQPISFRSGANPGFHEAIADIASLSVATPEYMQSVSLLPNFTDDPNGDLNFLMNQALTKVAFLPFGYLIDQWRWDVFSGDTPRPKYNSKWWHNRCKYQGVYPPVIRSEQDFDAGSKFHVPNNTPYIRYFVAHIIQFQFHEALCKAANNSRPLHRCNIANSKEAGKKLAELMKSGSSIPWPKVLENLTGSEKMSAKSLMAYYKPLIDWPEKRKPRAENWMGGKMSSWIV |
| Enzyme Length | 616 |
| Uniprot Accession Number | Q6Q4G4 |
| Absorption | |
| Active Site | ACT_SITE 377; /evidence=ECO:0000250 |
| Activity Regulation | ACTIVITY REGULATION: Activated by chloride. Inhibited by captopril and lisinopril, and to a lesser extent by delaprilat. {ECO:0000269|PubMed:15175004}. |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Release of a C-terminal dipeptide, oligopeptide-|-Xaa-Yaa, when Xaa is not Pro, and Yaa is neither Asp nor Glu. Thus, conversion of angiotensin I to angiotensin II, with increase in vasoconstrictor activity, but no action on angiotensin II.; EC=3.4.15.1; Evidence={ECO:0000269|PubMed:15175004}; |
| DNA Binding | |
| EC Number | 3.4.15.1 |
| Enzyme Function | |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (1); Chain (1); Glycosylation (6); Metal binding (2); Signal peptide (1) |
| Keywords | Carboxypeptidase;Glycoprotein;Hydrolase;Metal-binding;Metalloprotease;Protease;Secreted;Signal;Zinc |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted, extracellular space {ECO:0000305}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..23; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 71,481 |
| Kinetics | |
| Metal Binding | METAL 376; /note=Zinc; catalytic; /evidence=ECO:0000250; METAL 380; /note=Zinc; catalytic; /evidence=ECO:0000250 |
| Rhea ID | |
| Cross Reference Brenda |