| IED ID | IndEnz0002016542 |
| Enzyme Type ID | protease016542 |
| Protein Name |
Alpha-1-antichymotrypsin ACT Serpin A3 |
| Gene Name | SERPINA3 AACT |
| Organism | Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Ponginae Pongo Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) |
| Enzyme Sequence | MERMLPFLALGLLVAGFCPAVLCHPNCPLDEENPTQENQDRGTHVDLGLASTNVDFAFSLYKQLVLKAPDKNVIFSPLSISTALAFLSLGAHNTTLTEILTGLRFNLTETSEAEIHQSFQHLLRTLNQSSDELQLSMGNAMFVEEQLSLLDRFMEDAKRLYGSEAFATDFQDSAAAKKLINDYVKNRTRGKITDLIKDLDSQTMMVLVNYIFFKAKWKMPFDPQDTHQSRFYLSKKKWVMVPMMSLHHLTTPYFRDEELSCTVVELKYTGNASALFILPDQDKMEEVEAMLLPETLKRWRDSLEFRRIDELYLPKFSISRAFNLENILLQLGIVEAFTSKADLSGITGARNLVVSQVVHKAVLDVFEEGTEASAATAVKITLLSALVDPMTIVRFNRPFLMIIVPTDTQNLLFISKVINPKQA |
| Enzyme Length | 423 |
| Uniprot Accession Number | Q5R536 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2. {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Glycosylation (5); Region (1); Signal peptide (1); Site (1) |
| Keywords | Acute phase;Glycoprotein;Protease inhibitor;Reference proteome;Secreted;Serine protease inhibitor;Signal |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted {ECO:0000250}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..23; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 47,815 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |