| IED ID | IndEnz0002016553 |
| Enzyme Type ID | protease016553 |
| Protein Name |
ADAM 17-like protease EC 3.4.24.- |
| Gene Name | Tace CG7908 |
| Organism | Drosophila melanogaster (Fruit fly) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Panarthropoda Arthropoda Mandibulata Pancrustacea Hexapoda Insecta Dicondylia Pterygota (winged insects) Neoptera Endopterygota Diptera Brachycera Muscomorpha Eremoneura Cyclorrhapha Schizophora Acalyptratae Ephydroidea Drosophilidae (pomace flies) Drosophilinae Drosophilini Drosophila (fruit flies) Sophophora melanogaster group melanogaster subgroup Drosophila melanogaster (Fruit fly) |
| Enzyme Sequence | MFTKCISCCGLAIISVFFACLFVENCAALQKTLRHYEIFHKDDVVHRVVKRGAKHSTNPFNTIKEVEFTTLGKNFRLILHPHRDVLHSKFRAYAVDADGNETVVHMDHDSFYSGRVFGELESSVRAHIEDGTMTMSIHLPEETYHIEPSWRHLPEAKKDTMVAYKASDVKVHKNEAGATPKTCGYIKEGLELEDKEHGDTLDNELHTREKRQSDQYEYTPTKTRCPLLLVADYRFFQEMGGGNTKTTINYLISLIDRVHKIYNDTVWQDRSDQEGFKGMGFVIKKIVVHSEPTRLRGGEAHYNMIREKWDVRNLLEVFSREYSHKDFCLAHLFTDLKFEGGILGLAYVGSPRRNSVGGICTPEYFKNGYTLYLNSGLSSSRNHYGQRVITREADLVTAHEFGHNWGSEHDPDIPECSPSASQGGSFLMYTYSVSGYDVNNKKFSPCSLRSIRKVLQAKSGRCFSEPEESFCGNLRVEGDEQCDAGLLGTEDNDSCCDKNCKLRRNQGAMCSDKNSPCCQNCQFMASGMKCREAQYATCEQEARCTGAHAECPKSPAMADGTTCQERGQCRNGKCVPYCETQGLQSCMCDIIADACKRCCRMSINETCFPVEPPDVLPDGTPCITGFCNKGVCEKTIQDVVERFWDIIEEINVAKTLRFLKDNIVMAVVLVTAVFWIPISCVISYFDRKKLRHEMKLIEWSQKLDLIHPSDERRRVIHIRVPRQKISVARACN |
| Enzyme Length | 732 |
| Uniprot Accession Number | Q9VAC5 |
| Absorption | |
| Active Site | ACT_SITE 400; /evidence="ECO:0000255|PROSITE-ProRule:PRU00276, ECO:0000255|PROSITE-ProRule:PRU10095" |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.24.- |
| Enzyme Function | |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (1); Alternative sequence (2); Chain (1); Disulfide bond (7); Domain (2); Glycosylation (4); Metal binding (4); Motif (1); Propeptide (1); Region (2); Sequence caution (1); Sequence conflict (5); Signal peptide (1); Topological domain (2); Transmembrane (1) |
| Keywords | Alternative splicing;Cleavage on pair of basic residues;Disulfide bond;Glycoprotein;Hydrolase;Membrane;Metal-binding;Metalloprotease;Protease;Reference proteome;Signal;Transmembrane;Transmembrane helix;Zinc;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..28; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 11672524; 11799064; 15576412; 15943864; 18535782; 19234471; 20220848; 20371351; 21074052; 21483663; 21684629; 22868267; 22952997; 23071443; 23087838; 23352166; 24384567; 24704358; 24780858; 24981286; 25062361; 25312911; 25411211; 26437585; 27076079; 29107812; 31722958; 32358623; 32715522; 32901612; 34082046; 34140347; 34239451; |
| Motif | MOTIF 181..188; /note=Cysteine switch; /evidence=ECO:0000250 |
| Gene Encoded By | |
| Mass | 83,081 |
| Kinetics | |
| Metal Binding | METAL 183; /note=Zinc; in inhibited form; /evidence=ECO:0000250; METAL 399; /note=Zinc; catalytic; /evidence=ECO:0000250|UniProtKB:P78536; METAL 403; /note=Zinc; catalytic; /evidence=ECO:0000250|UniProtKB:P78536; METAL 409; /note=Zinc; catalytic; /evidence=ECO:0000250|UniProtKB:P78536 |
| Rhea ID | |
| Cross Reference Brenda |