| IED ID | IndEnz0002016561 |
| Enzyme Type ID | protease016561 |
| Protein Name |
Caspase-2 CASP-2 EC 3.4.22.55 ICH-1L/1S Protease ICH-1 Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12 |
| Gene Name | CASP2 ICH1 |
| Organism | Gallus gallus (Chicken) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Sauropsida Sauria (diapsids) Archelosauria Archosauria Dinosauria Saurischia Theropoda Coelurosauria Aves Neognathae Galloanserae Galliformes Phasianidae (turkeys) Phasianinae Gallus Gallus gallus (Chicken) |
| Enzyme Sequence | MLGACGMQRYHQEALKKNRVMLARELVLKELMEHMIEKDIITIEMVEMIQAKSGSFSQNVEFLNLLPKRGPNAFSAFCEALQETKQQHLAEMILKTESSLRHGIATLEQRYGSNLPLPLSESCNSKRPRLIVEHSLDSGDGPPIPPVKHCTPEFYRDHQHLAYKLISEPRGLALILSNIHFSSEKDLEYRSGGDVDCASLELLFKHLGYQVTVFHDQSAEEMESALERFSKLPDHQDVDSCIVALLSHGVEGGVYGTDGKLLQLQEAFRLFDNANCPNLQNKPKMFFIQACRGDETDRGVDQRDGKERSDSPGCEESDANKEENLKLRLPTRSDMICGYACLKGTAAMRNTKRGSWYIEALTTVFAEDSRDTHVADMLVKVNRQIKQREGYAPGTEFHRCKEMSEYCSTLCRDLYLFPGYVPGK |
| Enzyme Length | 424 |
| Uniprot Accession Number | Q98943 |
| Absorption | |
| Active Site | ACT_SITE 248; /evidence=ECO:0000250; ACT_SITE 291; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Strict requirement for an Asp residue at P1, with 316-asp being essential for proteolytic activity and has a preferred cleavage sequence of Val-Asp-Val-Ala-Asp-|-.; EC=3.4.22.55; |
| DNA Binding | |
| EC Number | 3.4.22.55 |
| Enzyme Function | FUNCTION: Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival. {ECO:0000250|UniProtKB:P42575}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Alternative sequence (2); Chain (3); Domain (1); Erroneous initiation (1); Propeptide (1); Region (1) |
| Keywords | Alternative splicing;Apoptosis;Hydrolase;Protease;Reference proteome;Thiol protease;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 14975933; |
| Motif | |
| Gene Encoded By | |
| Mass | 47,960 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda | 3.4.22.55; |