| IED ID | IndEnz0002016586 |
| Enzyme Type ID | protease016586 |
| Protein Name |
Disintegrin and metalloproteinase domain-containing protein 28 ADAM 28 EC 3.4.24.- Epididymal metalloproteinase-like, disintegrin-like, and cysteine-rich protein II eMDC II |
| Gene Name | ADAM28 |
| Organism | Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Cercopithecoidea Cercopithecidae (Old World monkeys) Cercopithecinae Macaca (macaques) Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) |
| Enzyme Sequence | MLQALLTVSLLLSPVPVSAIKELPGVKKYEVVYPIRLHPLHKREVKEPEQQEQFETELKYKMTVNGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQGHIINEKDSDASISTCRGLRGYFSQGNQRYFIEPLSPIHRDGQEHALFKYDPEEKNYDSTCGTDGVLWVHDLQNIARPATRLVKLNDGKVQKHEKYIEYYLVLDNGEFKKYNENQDEIRKRVFEMANYVNMLYKKLNTHVALVGMEIWTDEDKINITPNASFTLENFSKWRGSVLPRRKRHDIAQLITATEFAGMTVGLAFMSTMCSPYHSVGVVQDHSDNLLRVAGTMAHEMGHNFGMFHDNYSCKCPSTICVMDKALSFYIPTDFSSCSRVSYDKFFEDKLSNCLFNAPLPTDIISTPICGNQMVEMGEDCDCGTSEECTNICCDAKTCKIKAGFQCTSGECCEKCQFKKAGMVCRPAKDECDLPEMCDGKSGNCPDDRFRANGFPCHHGKGYCLMGACPTLQEQCTELWGPGTKVADQSCYNRNEGGSKYGYCRRVDDTLIPCKTNDTMCGKLFCQGGSDNLPWKGRIVTFLTCKTFDPEDTSEEIGMVANGTKCGHNKVCINAECVDIEKAYKSTNCSSKCKGHAVCDHELQCQCEEGWSPPDCDDSSVVFYFSIVVAVLFPVAVISLVVAIVIRQQSSREKQKKDQRPLSTTGTRPHKQKRKPQMVKAVQPQEMSQMKLHVYDLPVEGNEPPASFLISKPDFSPPPIPAPRSSSFLDSNPKA |
| Enzyme Length | 776 |
| Uniprot Accession Number | Q9XSL6 |
| Absorption | |
| Active Site | ACT_SITE 341; /evidence="ECO:0000255|PROSITE-ProRule:PRU00276, ECO:0000255|PROSITE-ProRule:PRU10095" |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.24.- |
| Enzyme Function | FUNCTION: May play a role in the adhesive and proteolytic events that occur during lymphocyte emigration or may function in ectodomain shedding of lymphocyte surface target proteins, such as FASL and CD40L. May be involved in sperm maturation. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (1); Chain (1); Compositional bias (1); Disulfide bond (7); Domain (3); Glycosylation (6); Metal binding (4); Motif (1); Propeptide (1); Region (2); Signal peptide (1); Topological domain (2); Transmembrane (1) |
| Keywords | Disulfide bond;EGF-like domain;Glycoprotein;Hydrolase;Membrane;Metal-binding;Metalloprotease;Protease;Reference proteome;Signal;Transmembrane;Transmembrane helix;Zinc;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. |
| Modified Residue | |
| Post Translational Modification | PTM: Pro-domain removal and maturation may be, at least in part, autocatalytic. {ECO:0000250}. |
| Signal Peptide | SIGNAL 1..19; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | MOTIF 168..175; /note=Cysteine switch; /evidence=ECO:0000250 |
| Gene Encoded By | |
| Mass | 87,214 |
| Kinetics | |
| Metal Binding | METAL 170; /note=Zinc; in inhibited form; /evidence=ECO:0000250; METAL 340; /note=Zinc; catalytic; /evidence=ECO:0000250; METAL 344; /note=Zinc; catalytic; /evidence=ECO:0000250; METAL 350; /note=Zinc; catalytic; /evidence=ECO:0000250 |
| Rhea ID | |
| Cross Reference Brenda |