| IED ID | IndEnz0002016629 |
| Enzyme Type ID | protease016629 |
| Protein Name |
Gamma-adducin Adducin-like protein 70 Protein kinase C-binding protein 35H |
| Gene Name | Add3 |
| Organism | Rattus norvegicus (Rat) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Rattus Rattus norvegicus (Rat) |
| Enzyme Sequence | MSSDSSQAVITTPPPPSMPHKERYFDRINESDPEYLRERNMSPDLREDFNMMEQRKRVTQILQSPAFREDLECLTQEQMKKGHDPTGLLALQQIADYIMANSFTGFSSPPLSLGMVTPINDLPGADTSSYVKGEKLTRCELASLYRLADLFGWAHLANTYISVRVSKEQDHIIIIPRGLPFSEATASALVKVNIIGEVVDQGSTNLKIDHSGFSPHAAIYSTRPDVKCVIHIHTLATAAVSSMKCGILPISQESLILGDVAYYDYQGSLDEEEERIELQKVLGPSCKVLVLRNHGVVALGETLEEAFHYIFNVQMACEIQVQAVAGAGGVDNLLILDLQKYKAFTHGVAMTGGGGVNMGSHQKWKVGEIEFEGLMRTLDNLGYRTGYAYRHPLVREKPRHKSDVEIPATVTAFSFEDDSVPLSPLKYMAQRQQREKTRWLNSPNTYMKVNVPEESRNGETSPRTKITWMKAEDPSKVSSGTPIKIEDPNQFVPLNTNPTEVLEKRNKIREQNRYDLKTAGPQSQLLAGIVVDKPPSTMRFEDDDQGPPAPPNPFSHLMEGELEEYTKTIERQQQGLDDAEQESLSDDAASVSQIQSQTQSPQSVPERLEENHELFSKSFTSVDVPVIVNGKDEMHDVEDELAQRVSRLTTSTTIENIEITIKSPDRTEEVLSPDGSPSKSPSKKKKKFRTPSFLKKNKKKEKVEA |
| Enzyme Length | 705 |
| Uniprot Accession Number | Q62847 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Plays a role in actin filament capping. Binds to calmodulin. {ECO:0000250|UniProtKB:Q9UEY8}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Alternative sequence (1); Chain (1); Compositional bias (2); Cross-link (1); Initiator methionine (1); Modified residue (17); Natural variant (1); Region (6); Sequence conflict (1) |
| Keywords | Acetylation;Actin-binding;Alternative splicing;Calmodulin-binding;Cell membrane;Cytoplasm;Cytoskeleton;Isopeptide bond;Membrane;Phosphoprotein;Reference proteome;Ubl conjugation |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side. |
| Modified Residue | MOD_RES 2; /note=N-acetylserine; /evidence=ECO:0000250|UniProtKB:Q9UEY8; MOD_RES 31; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:Q9QYB5; MOD_RES 42; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:Q9UEY8; MOD_RES 64; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:Q9UEY8; MOD_RES 402; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:Q9UEY8; MOD_RES 414; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:Q9QYB5; MOD_RES 423; /note=Phosphoserine; /evidence=ECO:0007744|PubMed:22673903; MOD_RES 442; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:Q9UEY8; MOD_RES 461; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:Q9UEY8; MOD_RES 583; /note=Phosphoserine; /evidence=ECO:0007744|PubMed:22673903; MOD_RES 585; /note=Phosphoserine; /evidence=ECO:0007744|PubMed:22673903; MOD_RES 590; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:Q9QYB5; MOD_RES 672; /note=Phosphoserine; /evidence=ECO:0007744|PubMed:22673903; MOD_RES 676; /note=Phosphoserine; /evidence=ECO:0007744|PubMed:22673903; MOD_RES 678; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:Q9QYB5; MOD_RES 680; /note=Phosphoserine; /evidence=ECO:0007744|PubMed:22673903; MOD_RES 682; /note=Phosphoserine; by PKC; /evidence=ECO:0000250|UniProtKB:Q9UEY8 |
| Post Translational Modification | PTM: Sumoylated. {ECO:0000250}. |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 10823823; 12364392; 15329129; 27927653; 32029431; 33308016; 33414130; 8442667; 9607561; |
| Motif | |
| Gene Encoded By | |
| Mass | 78,804 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |