Detail Information for IndEnz0002016638
IED ID IndEnz0002016638
Enzyme Type ID protease016638
Protein Name Calpain-10
EC 3.4.22.-
Calcium-activated neutral proteinase 10
CANP 10
Gene Name CAPN10 KIAA1845
Organism Homo sapiens (Human)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human)
Enzyme Sequence MRAGRGATPARELFRDAAFPAADSSLFCDLSTPLAQFREDITWRRPQEICATPRLFPDDPREGQVKQGLLGDCWFLCACAALQKSRHLLDQVIPPGQPSWADQEYRGSFTCRIWQFGRWVEVTTDDRLPCLAGRLCFSRCQREDVFWLPLLEKVYAKVHGSYEHLWAGQVADALVDLTGGLAERWNLKGVAGSGGQQDRPGRWEHRTCRQLLHLKDQCLISCCVLSPRAGARELGEFHAFIVSDLRELQGQAGQCILLLRIQNPWGRRCWQGLWREGGEGWSQVDAAVASELLSQLQEGEFWVEEEEFLREFDELTVGYPVTEAGHLQSLYTERLLCHTRALPGAWVKGQSAGGCRNNSGFPSNPKFWLRVSEPSEVYIAVLQRSRLHAADWAGRARALVGDSHTSWSPASIPGKHYQAVGLHLWKVEKRRVNLPRVLSMPPVAGTACHAYDREVHLRCELSPGYYLAVPSTFLKDAPGEFLLRVFSTGRVSLSAIRAVAKNTTPGAALPAGEWGTVQLRGSWRVGQTAGGSRNFASYPTNPCFPFSVPEGPGPRCVRITLHQHCRPSDTEFHPIGFHIFQVPEGGRSQDAPPLLLQEPLLSCVPHRYAQEVSRLCLLPAGTYKVVPSTYLPDTEGAFTVTIATRIDRPSIHSQEMLGQFLQEVSIMAVMKT
Enzyme Length 672
Uniprot Accession Number Q9HC96
Absorption
Active Site ACT_SITE 73; /evidence=ECO:0000250; ACT_SITE 238; /evidence=ECO:0000250; ACT_SITE 263; /evidence=ECO:0000250
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number 3.4.22.-
Enzyme Function FUNCTION: Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. May play a role in insulin-stimulated glucose uptake. {ECO:0000269|PubMed:17572128}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (3); Alternative sequence (12); Chain (1); Domain (1); Erroneous initiation (1); Natural variant (8); Region (2); Sequence conflict (3)
Keywords Alternative splicing;Diabetes mellitus;Hydrolase;Protease;Reference proteome;Repeat;Thiol protease
Interact With Q96G97-4; Q16595; P04792; P42858; Q99732; P02545-2; P10636; Q9P1N4
Induction
Subcellular Location
Modified Residue
Post Translational Modification
Signal Peptide
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID 11018080; 11481585; 11756346; 11756349; 11774208; 11872216; 11891023; 11935160; 11978669; 11980626; 12050223; 12107250; 12107735; 12133483; 12137596; 12145185; 12161543; 12453914; 12519860; 12843408; 12905623; 14500039; 14642065; 14741193; 15240652; 15641690; 15652721; 15696376; 16377260; 16790502; 16837224; 17106059; 17382509; 17570749; 17601994; 17608959; 18701098; 21030783; 21670566; 21864727; 21988832; 23035980; 25814554;
Motif
Gene Encoded By
Mass 74,952
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda 3.4.22.B30;