| IED ID | IndEnz0002016638 |
| Enzyme Type ID | protease016638 |
| Protein Name |
Calpain-10 EC 3.4.22.- Calcium-activated neutral proteinase 10 CANP 10 |
| Gene Name | CAPN10 KIAA1845 |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MRAGRGATPARELFRDAAFPAADSSLFCDLSTPLAQFREDITWRRPQEICATPRLFPDDPREGQVKQGLLGDCWFLCACAALQKSRHLLDQVIPPGQPSWADQEYRGSFTCRIWQFGRWVEVTTDDRLPCLAGRLCFSRCQREDVFWLPLLEKVYAKVHGSYEHLWAGQVADALVDLTGGLAERWNLKGVAGSGGQQDRPGRWEHRTCRQLLHLKDQCLISCCVLSPRAGARELGEFHAFIVSDLRELQGQAGQCILLLRIQNPWGRRCWQGLWREGGEGWSQVDAAVASELLSQLQEGEFWVEEEEFLREFDELTVGYPVTEAGHLQSLYTERLLCHTRALPGAWVKGQSAGGCRNNSGFPSNPKFWLRVSEPSEVYIAVLQRSRLHAADWAGRARALVGDSHTSWSPASIPGKHYQAVGLHLWKVEKRRVNLPRVLSMPPVAGTACHAYDREVHLRCELSPGYYLAVPSTFLKDAPGEFLLRVFSTGRVSLSAIRAVAKNTTPGAALPAGEWGTVQLRGSWRVGQTAGGSRNFASYPTNPCFPFSVPEGPGPRCVRITLHQHCRPSDTEFHPIGFHIFQVPEGGRSQDAPPLLLQEPLLSCVPHRYAQEVSRLCLLPAGTYKVVPSTYLPDTEGAFTVTIATRIDRPSIHSQEMLGQFLQEVSIMAVMKT |
| Enzyme Length | 672 |
| Uniprot Accession Number | Q9HC96 |
| Absorption | |
| Active Site | ACT_SITE 73; /evidence=ECO:0000250; ACT_SITE 238; /evidence=ECO:0000250; ACT_SITE 263; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.22.- |
| Enzyme Function | FUNCTION: Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. May play a role in insulin-stimulated glucose uptake. {ECO:0000269|PubMed:17572128}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Alternative sequence (12); Chain (1); Domain (1); Erroneous initiation (1); Natural variant (8); Region (2); Sequence conflict (3) |
| Keywords | Alternative splicing;Diabetes mellitus;Hydrolase;Protease;Reference proteome;Repeat;Thiol protease |
| Interact With | Q96G97-4; Q16595; P04792; P42858; Q99732; P02545-2; P10636; Q9P1N4 |
| Induction | |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 11018080; 11481585; 11756346; 11756349; 11774208; 11872216; 11891023; 11935160; 11978669; 11980626; 12050223; 12107250; 12107735; 12133483; 12137596; 12145185; 12161543; 12453914; 12519860; 12843408; 12905623; 14500039; 14642065; 14741193; 15240652; 15641690; 15652721; 15696376; 16377260; 16790502; 16837224; 17106059; 17382509; 17570749; 17601994; 17608959; 18701098; 21030783; 21670566; 21864727; 21988832; 23035980; 25814554; |
| Motif | |
| Gene Encoded By | |
| Mass | 74,952 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda | 3.4.22.B30; |