Detail Information for IndEnz0002016641
IED ID IndEnz0002016641
Enzyme Type ID protease016641
Protein Name Calpain-12
EC 3.4.22.-
Calcium-activated neutral proteinase 12
CANP 12
Gene Name Capn12
Organism Mus musculus (Mouse)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse)
Enzyme Sequence MASGNRKVTIQLVDDGAGTGAGGPQLFKGQNYEAIRRACLDSGILFRDPCFPAGPDALGYDKLGPDSEKAKGVEWKRPHEFCAEPQFICEDMSRTDVCQGSLGNCWLLAAAASLTLYPRLLYRVVPPGQGFQDGYAGVFHFQLWQFGRWVDVVVDDKLPVREGKLMFVRSEQRNEFWAPLLEKAYAKLHGSYEVMRGGHMNEAFVDFTGGVGEVLYLRQNTPGVFAALRHALAKESLVGATALSDRGEIRTDEGLVKGHAYSVTGTHKMSLGFTKVRLLRLRNPWGRVEWSGPWSDSCPRWDMLPSEWRDALLVKKEDGEFWMELQDFLTHFNTVQICSLSPEVLGPSPAGGGWHIHIFQGRWVRGFNSGGSQPSAENFWTNPQFRLTLLEPDEEEDDDDEEGPWGGWGAAGARGPARGGRVPKCTVLLSLIQRNRRCLRAKGLTYLTVGFHVFQIPEELLDLWDSPRSRALLPGLLRADRSVFCARRDVSRRCRLPPGHYLVVPSASRVGDEADFTLRIFSERSHTAVEIDDVISADLDALQAPYKPLELELAQLFLELAGEEEELNALQLQTLISIALEPARANTRTPGEIGLRTCEQLVQCFGRGQRLSLHHFQELWGHLMSWQATFDKFDEDASGTMNSCELRLALTAAGFHLNNQLTQSLTSRYRDSRLRVDFERFVGCAARLTCIFRHCCQHLDGGEGVVCLTHKQWSEVATFS
Enzyme Length 720
Uniprot Accession Number Q9ER56
Absorption
Active Site ACT_SITE 105; /evidence=ECO:0000250; ACT_SITE 259; /evidence=ECO:0000250; ACT_SITE 283; /evidence=ECO:0000250
Activity Regulation
Binding Site
Calcium Binding CA_BIND 634..645; /evidence=ECO:0000255|PROSITE-ProRule:PRU00448
catalytic Activity
DNA Binding
EC Number 3.4.22.-
Enzyme Function FUNCTION: Calcium-regulated non-lysosomal thiol-protease. {ECO:0000250}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (3); Alternative sequence (6); Calcium binding (1); Chain (1); Domain (2); Region (3)
Keywords Alternative splicing;Calcium;Hydrolase;Metal-binding;Protease;Reference proteome;Thiol protease
Interact With
Induction
Subcellular Location
Modified Residue
Post Translational Modification
Signal Peptide
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID 12466851; 27626380;
Motif
Gene Encoded By
Mass 80,588
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda 3.4.22.B32;