| IED ID | IndEnz0002016644 |
| Enzyme Type ID | protease016644 |
| Protein Name |
Apolipoprotein a Apo a Lp a EC 3.4.21.- |
| Gene Name | LPA |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MEHKEVVLLLLLFLKSAAPEQSHVVQDCYHGDGQSYRGTYSTTVTGRTCQAWSSMTPHQHNRTTENYPNAGLIMNYCRNPDAVAAPYCYTRDPGVRWEYCNLTQCSDAEGTAVAPPTVTPVPSLEAPSEQAPTEQRPGVQECYHGNGQSYRGTYSTTVTGRTCQAWSSMTPHSHSRTPEYYPNAGLIMNYCRNPDAVAAPYCYTRDPGVRWEYCNLTQCSDAEGTAVAPPTVTPVPSLEAPSEQAPTEQRPGVQECYHGNGQSYRGTYSTTVTGRTCQAWSSMTPHSHSRTPEYYPNAGLIMNYCRNPDAVAAPYCYTRDPGVRWEYCNLTQCSDAEGTAVAPPTVTPVPSLEAPSEQAPTEQRPGVQECYHGNGQSYRGTYSTTVTGRTCQAWSSMTPHSHSRTPEYYPNAGLIMNYCRNPDAVAAPYCYTRDPGVRWEYCNLTQCSDAEGTAVAPPTVTPVPSLEAPSEQAPTEQRPGVQECYHGNGQSYRGTYSTTVTGRTCQAWSSMTPHSHSRTPEYYPNAGLIMNYCRNPDAVAAPYCYTRDPGVRWEYCNLTQCSDAEGTAVAPPTVTPVPSLEAPSEQAPTEQRPGVQECYHGNGQSYRGTYSTTVTGRTCQAWSSMTPHSHSRTPEYYPNAGLIMNYCRNPDAVAAPYCYTRDPGVRWEYCNLTQCSDAEGTAVAPPTVTPVPSLEAPSEQAPTEQRPGVQECYHGNGQSYRGTYSTTVTGRTCQAWSSMTPHSHSRTPEYYPNAGLIMNYCRNPDAVAAPYCYTRDPGVRWEYCNLTQCSDAEGTAVAPPTVTPVPSLEAPSEQAPTEQRPGVQECYHGNGQSYRGTYSTTVTGRTCQAWSSMTPHSHSRTPEYYPNAGLIMNYCRNPDPVAAPYCYTRDPSVRWEYCNLTQCSDAEGTAVAPPTITPIPSLEAPSEQAPTEQRPGVQECYHGNGQSYQGTYFITVTGRTCQAWSSMTPHSHSRTPAYYPNAGLIKNYCRNPDPVAAPWCYTTDPSVRWEYCNLTRCSDAEWTAFVPPNVILAPSLEAFFEQALTEETPGVQDCYYHYGQSYRGTYSTTVTGRTCQAWSSMTPHQHSRTPENYPNAGLTRNYCRNPDAEIRPWCYTMDPSVRWEYCNLTQCLVTESSVLATLTVVPDPSTEASSEEAPTEQSPGVQDCYHGDGQSYRGSFSTTVTGRTCQSWSSMTPHWHQRTTEYYPNGGLTRNYCRNPDAEISPWCYTMDPNVRWEYCNLTQCPVTESSVLATSTAVSEQAPTEQSPTVQDCYHGDGQSYRGSFSTTVTGRTCQSWSSMTPHWHQRTTEYYPNGGLTRNYCRNPDAEIRPWCYTMDPSVRWEYCNLTQCPVMESTLLTTPTVVPVPSTELPSEEAPTENSTGVQDCYRGDGQSYRGTLSTTITGRTCQSWSSMTPHWHRRIPLYYPNAGLTRNYCRNPDAEIRPWCYTMDPSVRWEYCNLTRCPVTESSVLTTPTVAPVPSTEAPSEQAPPEKSPVVQDCYHGDGRSYRGISSTTVTGRTCQSWSSMIPHWHQRTPENYPNAGLTENYCRNPDSGKQPWCYTTDPCVRWEYCNLTQCSETESGVLETPTVVPVPSMEAHSEAAPTEQTPVVRQCYHGNGQSYRGTFSTTVTGRTCQSWSSMTPHRHQRTPENYPNDGLTMNYCRNPDADTGPWCFTMDPSIRWEYCNLTRCSDTEGTVVAPPTVIQVPSLGPPSEQDCMFGNGKGYRGKKATTVTGTPCQEWAAQEPHRHSTFIPGTNKWAGLEKNYCRNPDGDINGPWCYTMNPRKLFDYCDIPLCASSSFDCGKPQVEPKKCPGSIVGGCVAHPHSWPWQVSLRTRFGKHFCGGTLISPEWVLTAAHCLKKSSRPSSYKVILGAHQEVNLESHVQEIEVSRLFLEPTQADIALLKLSRPAVITDKVMPACLPSPDYMVTARTECYITGWGETQGTFGTGLLKEAQLLVIENEVCNHYKYICAEHLARGTDSCQGDSGGPLVCFEKDKYILQGVTSWGLGCARPNKPGVYARVSRFVTWIEGMMRNN |
| Enzyme Length | 2040 |
| Uniprot Accession Number | P08519 |
| Absorption | |
| Active Site | ACT_SITE 1861; /note=Charge relay system; /evidence=ECO:0000255|PROSITE-ProRule:PRU00274; ACT_SITE 1904; /note=Charge relay system; /evidence=ECO:0000255|PROSITE-ProRule:PRU00274; ACT_SITE 1990; /note=Charge relay system; /evidence=ECO:0000255|PROSITE-ProRule:PRU00274 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.21.- |
| Enzyme Function | FUNCTION: Apo(a) is the main constituent of lipoprotein(a) (Lp(a)). It has serine proteinase activity and is able of autoproteolysis. Inhibits tissue-type plasminogen activator 1. Lp(a) may be a ligand for megalin/Gp 330. {ECO:0000269|PubMed:2531657}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Beta strand (22); Chain (1); Disulfide bond (52); Domain (17); Glycosylation (17); Helix (1); Natural variant (11); Signal peptide (1); Turn (7) |
| Keywords | 3D-structure;Atherosclerosis;Autocatalytic cleavage;Disulfide bond;Glycoprotein;Hydrolase;Kringle;Lipid transport;Protease;Reference proteome;Repeat;Serine protease;Signal;Transport |
| Interact With | P02749; P02751 |
| Induction | |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | PTM: N- and O-glycosylated. The N-glycans are complex biantennary structures present in either a mono- or disialylated state. The O-glycans are mostly (80%) represented by the monosialylated core type I structure, NeuNAcalpha2-3Galbeta1-3GalNAc, with smaller amounts of disialylated and non-sialylated O-glycans also detected. {ECO:0000269|PubMed:11294842}. |
| Signal Peptide | SIGNAL 1..19; /evidence=ECO:0000255 |
| Structure 3D | NMR spectroscopy (2); X-ray crystallography (11) |
| Cross Reference PDB | 1I71; 1JFN; 1KIV; 2FEB; 3KIV; 4BV5; 4BV7; 4BVC; 4BVD; 4BVV; 4BVW; 4KIV; 6RX7; |
| Mapped Pubmed ID | 10026282; 11126727; 11332648; 11369850; 11440434; 11485023; 11781107; 11822583; 11833851; 11865151; 11947970; 11999088; 12082592; 12127051; 12220441; 12359323; 12482643; 12578871; 12738397; 12940514; 14746139; 15041277; 15258620; 15479125; 15515480; 15543335; 15654123; 15708348; 15905467; 15983325; 16053196; 16113787; 16150826; 16197951; 16202171; 16403785; 16497311; 16625232; 16840570; 16893192; 17145597; 17263558; 17460176; 17462619; 17478739; 17537433; 17569884; 17603063; 17683612; 17845920; 17908332; 17923276; 17942087; 17975119; 18086931; 18163888; 18280807; 18304554; 18386550; 18464913; 18479303; 18513389; 18560444; 18582452; 18594118; 18599799; 18622136; 18660489; 18682748; 18682798; 18775538; 18776185; 18806883; 18848929; 18983515; 19014618; 19023099; 19124843; 19131662; 19198611; 19222374; 19233690; 19263529; 19335423; 19348789; 19349573; 19479237; 19496273; 19509380; 19545557; 19564206; 19572086; 19636317; 19642912; 19646429; 19672030; 19808717; 19880117; 19913121; 19948975; 20014954; 20026018; 20032323; 20036902; 20106478; 20129380; 20129381; 20129382; 20143106; 20160194; 20197188; 20303190; 20379614; 20444451; 20452482; 20580413; 20593350; 20601648; 20605575; 20628086; 20673868; 20679960; 20691971; 20705065; 20971364; 21078622; 21086792; 21127300; 21153771; 21179199; 21231777; 21252144; 21283670; 21300353; 21473861; 21484527; 21519277; 21592478; 21749171; 21802535; 21907882; 21914687; 21914962; 21970553; 21986921; 22010162; 22134617; 22192511; 22207727; 22283971; 22327610; 22387060; 22407494; 22422337; 22485129; 22516069; 22633661; 22633779; 22710560; 22748161; 22762941; 23010950; 23036009; 23040268; 23099120; 23137279; 23165148; 23183511; 23202367; 23243000; 23357149; 23375930; 23388002; 23484137; 23552902; 23652366; 23667177; 23701863; 23701995; 23735648; 23903772; 23914433; 23951216; 23973688; 24083682; 24089516; 24092750; 24161323; 24243886; 24356104; 24502962; 24622370; 24632281; 24751932; 24760552; 24776095; 24781076; 24790998; 24839811; 24859635; 24880474; 24888427; 24925971; 24937703; 24972322; 24977982; 25142165; 25314652; 25463112; 25490096; 25575512; 25613532; 25614280; 25633186; 25649924; 25676008; 25778403; 25810300; 25852127; 25861813; 25865336; 25871336; 25936305; 25936312; 25936320; 25936321; 25936330; 25936334; 25938632; 26147378; 26222903; 26224810; 26298741; 26302166; 26361154; 26377243; 26407666; 26412029; 26515419; 26518096; 26546997; 26632531; 26637279; 26685327; 26710333; 26776177; 26803430; 26827667; 26880352; 26900838; 26936452; 26947887; 26975530; 27005778; 27055974; 27074913; 27075991; 27102113; 27185354; 27393854; 27417585; 27417586; 27497100; 27540729; 27651445; 27659098; 27677946; 27756118; 27821413; 27825299; 27856951; 27998826; 28004340; 28160245; 28185214; 28185944; 28229283; 28233270; 28265881; 28320383; 28320808; 28321012; 28336560; 28351002; 28379036; 28429674; 28444229; 28444976; 28554015; 28566218; 28632940; 28729361; 28830274; 28899393; 28971985; 29128868; 29129821; 29182987; 29258004; 29301785; 29310992; 29457025; 29550494; 29567679; 29703846; 29747697; 29960898; 29973585; 29990619; 30006322; 30030022; 30071823; 30099661; 30100157; 30170223; 30234895; 30270088; 30482443; 30600215; 30601635; 30786745; 31032650; 31079266; 31103339; 31113255; 31141105; 31280836; 31286992; 31371270; 31437611; 31551368; 31597550; 31686591; 31740238; 31917789; 32013705; 32078365; 32081604; 32160811; 32203743; 32220223; 32284623; 32304380; 32307429; 32343731; 32381650; 32390399; 32466883; 32620506; 32630105; 32636121; 32646432; 32666413; 32681934; 32703886; 32710255; 32825847; 32882349; 32889667; 32907988; 33040574; 33100089; 33115266; 33115273; 33333178; 33423974; 33568105; 33613445; 33730874; 33814236; 34074296; 34107870; 34194581; 34237965; 34325833; 34407812; 34995986; 9269765; 9548923; |
| Motif | |
| Gene Encoded By | |
| Mass | 226,546 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |