| IED ID | IndEnz0002016645 |
| Enzyme Type ID | protease016645 |
| Protein Name |
Retroviral-like aspartic protease 1 EC 3.4.23.- Skin-specific retroviral-like aspartic protease SASPase Skin aspartic protease TPA-inducible aspartic proteinase-like protein |
| Gene Name | Asprv1 Sasp Taps |
| Organism | Mus musculus (Mouse) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse) |
| Enzyme Sequence | MRNPGGPGWASKRPLQKKQNTACLCAQQPARHFVPAPFNSSRQGKNTAQPTEPSLSSVIAPTLFCAFLYLACVTAELPEVSRRMATSGVRSKEGRREHAFVPEPFTGTNLAPSLWLHRFEVIDDLNHWDHATKLRFLKESLKGDALDVYNGLSSQAQGDFSFVKQALLRAFGAPGEAFSEPEEILFANSMGKGYYLKGKVGHVPVRFLVDSGAQVSVVHPALWEEVTDGDLDTLRPFNNVVKVANGAEMKILGVWDTEISLGKTKLKAEFLVANASAEEAIIGTDVLQDHNAVLDFEHRTCTLKGKKFRLLPVGSSLEDEFDLELIEEEEGSSAPEGSH |
| Enzyme Length | 339 |
| Uniprot Accession Number | Q09PK2 |
| Absorption | |
| Active Site | ACT_SITE 210; /evidence=ECO:0000255|PROSITE-ProRule:PRU10094 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.23.- |
| Enzyme Function | FUNCTION: Protease responsible for filaggrin processing, essential for the maintenance of a proper epidermis organization. {ECO:0000250|UniProtKB:Q53RT3}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (1); Chain (1); Compositional bias (1); Domain (1); Erroneous initiation (1); Glycosylation (2); Mutagenesis (1); Propeptide (2); Region (1); Sequence conflict (1); Transmembrane (1) |
| Keywords | Aspartyl protease;Autocatalytic cleavage;Direct protein sequencing;Glycoprotein;Hydrolase;Membrane;Protease;Reference proteome;Transmembrane;Transmembrane helix |
| Interact With | |
| Induction | INDUCTION: By 12-O-tetradecanoylphorbol-13-acetate (TPA). No TPA-induced expression is seen in mice lacking Fos. {ECO:0000269|PubMed:16565508}. |
| Subcellular Location | SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}. |
| Modified Residue | |
| Post Translational Modification | PTM: Undergoes autocleavage which is necessary for activation of the protein. {ECO:0000269|PubMed:16837463}. |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 11217851; 12466851; 20237492; 21267068; 29212956; 30534943; |
| Motif | |
| Gene Encoded By | |
| Mass | 37,174 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |