Detail Information for IndEnz0002016684
IED ID IndEnz0002016684
Enzyme Type ID protease016684
Protein Name Chymotrypsin-like elastase family member 2A
EC 3.4.21.71
Elastase-2
Elastase-2A
Gene Name CELA2A ELA2 ELA2A
Organism Sus scrofa (Pig)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Laurasiatheria Artiodactyla Suina Suidae (pigs) Sus Sus scrofa (Pig)
Enzyme Sequence MIRALLLSTLVAGALSCGLPANLPQLPRVVGGEDARPNSWPWQVSLQYDSSGQWRHTCGGTLVDQSWVLTAAHCISSSRTYRVVLGRHSLSTNEPGSLAVKVSKLVVHQDWNSNQLSNGNDIALLKLASPVSLTDKIQLGCLPAAGTILPNNYVCYVTGWGRLQTNGASPDILQQGQLLVVDYATCSKPGWWGSTVKTNMICAGGDGIISSCNGDSGGPLNCQGANGQWQVHGIVSFGSSLGCNYYHKPSVFTRVSNYIDWINSVIANN
Enzyme Length 269
Uniprot Accession Number P08419
Absorption
Active Site ACT_SITE 73; /note=Charge relay system; ACT_SITE 121; /note=Charge relay system; ACT_SITE 216; /note=Charge relay system
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity CATALYTIC ACTIVITY: Reaction=Preferential cleavage: Leu-|-Xaa, Met-|-Xaa and Phe-|-Xaa. Hydrolyzes elastin.; EC=3.4.21.71; Evidence={ECO:0000250|UniProtKB:P08217};
DNA Binding
EC Number 3.4.21.71
Enzyme Function FUNCTION: Elastase that enhances insulin signaling and might have a physiologic role in cellular glucose metabolism. Circulates in plasma and reduces platelet hyperactivation, triggers both insulin secretion and degradation, and increases insulin sensitivity. {ECO:0000250|UniProtKB:P08217}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (3); Beta strand (15); Chain (1); Disulfide bond (4); Domain (1); Helix (6); Propeptide (1); Sequence conflict (5); Signal peptide (1); Turn (1)
Keywords 3D-structure;Disulfide bond;Hydrolase;Protease;Reference proteome;Secreted;Serine protease;Signal;Zymogen
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P08217}.
Modified Residue
Post Translational Modification
Signal Peptide SIGNAL 1..16
Structure 3D X-ray crystallography (1)
Cross Reference PDB 1BRU;
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 28,699
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda