Detail Information for IndEnz0002016701
IED ID IndEnz0002016701
Enzyme Type ID protease016701
Protein Name Probable Xaa-Pro aminopeptidase pepP
EC 3.4.11.9
Aminoacylproline aminopeptidase
Prolidase
Gene Name pepP PMAA_069810
Organism Talaromyces marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333) (Penicillium marneffei)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Pezizomycotina leotiomyceta Eurotiomycetes Eurotiomycetidae Eurotiales (green and blue molds) Trichocomaceae Talaromyces Talaromyces sect. Talaromyces Talaromyces marneffei (Penicillium marneffei) Talaromyces marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333) (Penicillium marneffei)
Enzyme Sequence MTSTDGILAGKYPAKAHARRVVEYLRQNGFQGDGVLYLEAQKTRMIEDNDSEQPFRQRRFFFYLSGCLLPDAHLTYHISTDKLTLFIPPLDPESVIWSGLPLSPAQAKELYDVDEVLYTTDVNPTLAHLASKVGFVFAIDGQISDDVSLKSFPDTDKVALKTAIEECRAVKDAYEVAMIRKANDVTSQAHVAVLKAAKSATNERELEAAFIGTCIAQGCREMAYHPIVASGTSSATLHYVNNDEPLIDSSTNKKKLNLLLDAAGEYKAYCADVTRTFPLSGKFSPESREIYDIVLEMQTESLAMLKEGVLWEDVHITAHRVAIKGLLKLGILRGSEEELLEKRVSVAFFPHGLGHYLGMDTHDTGGHANYADKDKMFQYLRVRGKLPAGSVITVEPGVYFCRFIIEPYLKDSELSKYIDADVLEKYWEVGGVRIEDNIHITKEGHENLTTAPKTADQVELMINGS
Enzyme Length 465
Uniprot Accession Number B6Q8T5
Absorption
Active Site
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity CATALYTIC ACTIVITY: Reaction=Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.; EC=3.4.11.9;
DNA Binding
EC Number 3.4.11.9
Enzyme Function FUNCTION: Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides. {ECO:0000250}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Chain (1); Metal binding (6)
Keywords Aminopeptidase;Hydrolase;Manganese;Metal-binding;Metalloprotease;Protease;Reference proteome
Interact With
Induction
Subcellular Location
Modified Residue
Post Translational Modification
Signal Peptide
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 51,734
Kinetics
Metal Binding METAL 261; /note=Manganese 2; /evidence=ECO:0000250; METAL 272; /note=Manganese 1; /evidence=ECO:0000250; METAL 272; /note=Manganese 2; /evidence=ECO:0000250; METAL 395; /note=Manganese 1; /evidence=ECO:0000250; METAL 435; /note=Manganese 1; /evidence=ECO:0000250; METAL 435; /note=Manganese 2; /evidence=ECO:0000250
Rhea ID
Cross Reference Brenda