Detail Information for IndEnz0002016707
IED ID IndEnz0002016707
Enzyme Type ID protease016707
Protein Name CASP8 and FADD-like apoptosis regulator
Caspase homolog
CASH
Caspase-eight-related protein
Casper
Caspase-like apoptosis regulatory protein
CLARP
Cellular FLICE-like inhibitory protein
c-FLIP
FADD-like antiapoptotic molecule 1
FLAME-1
Inhibitor of FLICE
I-FLICE
MACH-related inducer of toxicity
MRIT
Usurpin

Cleaved into: CASP8 and FADD-like apoptosis regulator subunit p43; CASP8 and FADD-like apoptosis regulator subunit p12
Gene Name Cflar Cash
Organism Mus musculus (Mouse)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse)
Enzyme Sequence MAQSPVSAEVIHQVEECLDEDEKEMMLFLCRDVTENLAAPNVRDLLDSLSERGQLSFATLAELLYRVRRFDLLKRILKTDKATVEDHLRRNPHLVSDYRVLLMEIGESLDQNDVSSLVFLTRDYTGRGKIAKDKSFLDLVIELEKLNLIASDQLNLLEKCLKNIHRIDLNTKIQKYTQSSQGARSNMNTLQASLPKLSIKYNSRLQNGRSKEPRFVEYRDSQRTLVKTSIQESGAFLPPHIREETYRMQSKPLGICLIIDCIGNDTKYLQETFTSLGYHIQLFLFPKSHDITQIVRRYASMAQHQDYDSFACVLVSLGGSQSMMGRDQVHSGFSLDHVKNMFTGDTCPSLRGKPKLFFIQNYESLGSQLEDSSLEVDGPSIKNVDSKPLQPRHCTTHPEADIFWSLCTADVSHLEKPSSSSSVYLQKLSQQLKQGRRRPLVDLHVELMDKVYAWNSGVSSKEKYSLSLQHTLRKKLILAPT
Enzyme Length 481
Uniprot Accession Number O35732
Absorption
Active Site
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number
Enzyme Function FUNCTION: Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:10602037, ECO:0000269|PubMed:10894163}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Alternative sequence (2); Chain (2); Domain (2); Mutagenesis (2); Region (8); Sequence conflict (2); Site (2)
Keywords Alternative splicing;Apoptosis;Reference proteome;Repeat
Interact With
Induction INDUCTION: Isoform 1 but not isoform 2 is activated by BCR cross-linking in primary B-cells.
Subcellular Location
Modified Residue
Post Translational Modification PTM: Proteolytically processed by CASP8 generating subunits p43 and p12. {ECO:0000269|PubMed:31511692}.
Signal Peptide
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID 10725249; 11016460; 11217851; 11247636; 11544288; 12135878; 12244156; 12466851; 12477972; 14551207; 14610273; 15282307; 15557152; 15761846; 15815586; 15899875; 15917295; 15972663; 16043517; 16141072; 16263940; 16306425; 16397188; 16469705; 16487007; 16602821; 16783640; 17056040; 17237443; 17372587; 17448907; 17462996; 17464994; 17488888; 17581950; 17699753; 17823262; 17878261; 17975479; 18081036; 18219316; 18356280; 18390734; 18566605; 18708583; 18832693; 19109151; 19285665; 19300454; 19322522; 19373244; 19429865; 19433309; 19587217; 20100735; 20335528; 20427667; 20724542; 20739833; 20980680; 21267068; 21364645; 21368763; 21435442; 21677750; 21703207; 21803845; 21862448; 22089168; 22095280; 22202974; 22393362; 22406316; 22582174; 22675671; 22700824; 23012479; 23144495; 23175183; 23250397; 23313194; 23424201; 23505065; 23828575; 24036366; 24095739; 24209745; 24270411; 24275659; 24557836; 24722293; 24813850; 24952961; 25087120; 25342470; 25500368; 25501600; 25725104; 25746012; 25963626; 26238491; 26582200; 26798068; 27106802; 27267061; 27523270; 27619661; 27819682; 28052242; 28218919; 28850249; 29099934; 29107687; 29191940; 29596938; 30185824; 31132747; 31387178; 31723262; 32103006; 32193329; 33238518; 33269646; 33354276; 34238932; 34545139; 9729047;
Motif
Gene Encoded By
Mass 54,875
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda