Detail Information for IndEnz0002016708
IED ID IndEnz0002016708
Enzyme Type ID protease016708
Protein Name Chymotrypsin-like elastase family member 1
EC 3.4.21.36
Elastase-1
Gene Name Cela1 Ela1
Organism Mus musculus (Mouse)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse)
Enzyme Sequence MLRFLVFASLVLCGHSTEDVPETDARVVGGAEARRNSWPSQISLQYQYGGSWHHTCGGTLIRSNWVMTAAHCVDSPMTYRVVVGEHNLSQNDGTEQYVNVQKIVSHPYWNKNNVVAGYDIALLRLAKSVTLNNYVQLGVLPREGTILANNSPCYITGWGRTRTNGELAQTLQQAYLPSVSYSICSSSSYWGSSVKNTMVCAGGDGVRSGCQGDSGGPLHCMVNGQYAVHGVTSFVSSMGCNVARKPTVFTRVSAYISWMNNVIASN
Enzyme Length 266
Uniprot Accession Number Q91X79
Absorption
Active Site ACT_SITE 71; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 119; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 214; /note=Charge relay system; /evidence=ECO:0000250
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity CATALYTIC ACTIVITY: Reaction=Hydrolysis of proteins, including elastin. Preferential cleavage: Ala-|-Xaa.; EC=3.4.21.36;
DNA Binding
EC Number 3.4.21.36
Enzyme Function FUNCTION: Acts upon elastin. {ECO:0000250}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (3); Chain (1); Disulfide bond (4); Domain (1); Glycosylation (1); Metal binding (3); Propeptide (1); Sequence conflict (8); Signal peptide (1)
Keywords Calcium;Disulfide bond;Glycoprotein;Hydrolase;Metal-binding;Protease;Reference proteome;Secreted;Serine protease;Signal;Zymogen
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
Modified Residue
Post Translational Modification
Signal Peptide SIGNAL 1..16; /evidence=ECO:0000255
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID 11217851; 11961105; 12189154; 12466851; 1354638; 1358803; 14610273; 14729487; 16518820; 17222338; 17901120; 17938243; 18554416; 19085241; 20003319; 21267068; 21677750; 24793170; 25186293; 26443822; 28071719; 29420065; 33032092; 33567267; 6589791; 8012111; 8530040; 9851981;
Motif
Gene Encoded By
Mass 28,901
Kinetics
Metal Binding METAL 85; /note=Calcium; /evidence=ECO:0000250; METAL 90; /note=Calcium; via carbonyl oxygen; /evidence=ECO:0000250; METAL 95; /note=Calcium; /evidence=ECO:0000250
Rhea ID
Cross Reference Brenda