Detail Information for IndEnz0002016723
IED ID IndEnz0002016723
Enzyme Type ID protease016723
Protein Name Archaemetzincin-2
EC 3.4.-.-
Archeobacterial metalloproteinase-like protein 2
Gene Name AMZ2 BM-014
Organism Homo sapiens (Human)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human)
Enzyme Sequence MQIIRHSEQTLKTALISKNPVLVSQYEKLNAGEQRLMNEAFQPASDLFGPITLHSPSDWITSHPEAPQDFEQFFSDPYRKTPSPNKRSIYIQSIGSLGNTRIISEEYIKWLTGYCKAYFYGLRVKLLEPVPVSVTRCSFRVNENTHNLQIHAGDILKFLKKKKPEDAFCVVGITMIDLYPRDSWNFVFGQASLTDGVGIFSFARYGSDFYSMHYKGKVKKLKKTSSSDYSIFDNYYIPEITSVLLLRSCKTLTHEIGHIFGLRHCQWLACLMQGSNHLEEADRRPLNLCPICLHKLQCAVGFSIVERYKALVRWIDDESSDTPGATPEHSHEDNGNLPKPVEAFKEWKEWIIKCLAVLQK
Enzyme Length 360
Uniprot Accession Number Q86W34
Absorption
Active Site ACT_SITE 255; /note=Proton acceptor; /evidence=ECO:0000255|PROSITE-ProRule:PRU10095
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number 3.4.-.-
Enzyme Function FUNCTION: Probable zinc metalloprotease. {ECO:0000250|UniProtKB:Q8TXW1}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (1); Alternative sequence (1); Chain (1); Erroneous termination (1); Frameshift (1); Metal binding (7); Natural variant (2); Sequence conflict (13)
Keywords Alternative splicing;Hydrolase;Metal-binding;Metalloprotease;Protease;Reference proteome;Zinc
Interact With
Induction
Subcellular Location
Modified Residue
Post Translational Modification
Signal Peptide
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID 20379614; 26496610;
Motif
Gene Encoded By
Mass 41,263
Kinetics
Metal Binding METAL 254; /note=Zinc 1; via pros nitrogen; catalytic; /evidence=ECO:0000250|UniProtKB:Q8TXW1; METAL 258; /note=Zinc 1; via pros nitrogen; catalytic; /evidence=ECO:0000250|UniProtKB:Q8TXW1; METAL 264; /note=Zinc 1; via pros nitrogen; catalytic; /evidence=ECO:0000250|UniProtKB:Q8TXW1; METAL 265; /note=Zinc 2; /evidence=ECO:0000250|UniProtKB:Q8TXW1; METAL 270; /note=Zinc 2; /evidence=ECO:0000250|UniProtKB:Q8TXW1; METAL 289; /note=Zinc 2; /evidence=ECO:0000250|UniProtKB:Q8TXW1; METAL 292; /note=Zinc 2; /evidence=ECO:0000250|UniProtKB:Q8TXW1
Rhea ID
Cross Reference Brenda