| IED ID | IndEnz0002016723 |
| Enzyme Type ID | protease016723 |
| Protein Name |
Archaemetzincin-2 EC 3.4.-.- Archeobacterial metalloproteinase-like protein 2 |
| Gene Name | AMZ2 BM-014 |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MQIIRHSEQTLKTALISKNPVLVSQYEKLNAGEQRLMNEAFQPASDLFGPITLHSPSDWITSHPEAPQDFEQFFSDPYRKTPSPNKRSIYIQSIGSLGNTRIISEEYIKWLTGYCKAYFYGLRVKLLEPVPVSVTRCSFRVNENTHNLQIHAGDILKFLKKKKPEDAFCVVGITMIDLYPRDSWNFVFGQASLTDGVGIFSFARYGSDFYSMHYKGKVKKLKKTSSSDYSIFDNYYIPEITSVLLLRSCKTLTHEIGHIFGLRHCQWLACLMQGSNHLEEADRRPLNLCPICLHKLQCAVGFSIVERYKALVRWIDDESSDTPGATPEHSHEDNGNLPKPVEAFKEWKEWIIKCLAVLQK |
| Enzyme Length | 360 |
| Uniprot Accession Number | Q86W34 |
| Absorption | |
| Active Site | ACT_SITE 255; /note=Proton acceptor; /evidence=ECO:0000255|PROSITE-ProRule:PRU10095 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.-.- |
| Enzyme Function | FUNCTION: Probable zinc metalloprotease. {ECO:0000250|UniProtKB:Q8TXW1}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (1); Alternative sequence (1); Chain (1); Erroneous termination (1); Frameshift (1); Metal binding (7); Natural variant (2); Sequence conflict (13) |
| Keywords | Alternative splicing;Hydrolase;Metal-binding;Metalloprotease;Protease;Reference proteome;Zinc |
| Interact With | |
| Induction | |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 20379614; 26496610; |
| Motif | |
| Gene Encoded By | |
| Mass | 41,263 |
| Kinetics | |
| Metal Binding | METAL 254; /note=Zinc 1; via pros nitrogen; catalytic; /evidence=ECO:0000250|UniProtKB:Q8TXW1; METAL 258; /note=Zinc 1; via pros nitrogen; catalytic; /evidence=ECO:0000250|UniProtKB:Q8TXW1; METAL 264; /note=Zinc 1; via pros nitrogen; catalytic; /evidence=ECO:0000250|UniProtKB:Q8TXW1; METAL 265; /note=Zinc 2; /evidence=ECO:0000250|UniProtKB:Q8TXW1; METAL 270; /note=Zinc 2; /evidence=ECO:0000250|UniProtKB:Q8TXW1; METAL 289; /note=Zinc 2; /evidence=ECO:0000250|UniProtKB:Q8TXW1; METAL 292; /note=Zinc 2; /evidence=ECO:0000250|UniProtKB:Q8TXW1 |
| Rhea ID | |
| Cross Reference Brenda |