IED ID | IndEnz0002016753 |
Enzyme Type ID | protease016753 |
Protein Name |
AMSH-like ubiquitin thioesterase 2 EC 3.4.19.- Deubiquitinating enzyme AMSH2 |
Gene Name | AMSH2 At1g10600 F20B24.2 T10O24.25 |
Organism | Arabidopsis thaliana (Mouse-ear cress) |
Taxonomic Lineage | cellular organisms Eukaryota Viridiplantae Streptophyta Streptophytina Embryophyta Tracheophyta Euphyllophyta Spermatophyta Magnoliopsida Mesangiospermae eudicotyledons Gunneridae Pentapetalae rosids malvids Brassicales Brassicaceae Camelineae Arabidopsis Arabidopsis thaliana (Mouse-ear cress) |
Enzyme Sequence | MVTLSSPSPSLSCVENVTCKSSHVSRVLISGTDNINHGESSEAKILRDVHISERLLEDFTELARENTEKDLETCGTLAAFLERGIFYVTTLIIPKQESTSNSCQAMNEVEVFSIQNERELYPVGWIHTHPSQGCFMSSVDLHTHYSYQVMVPEAFAIVVAPTDSSKSYGIFKLTDPGGMEVLRGCSETGFHPHKEPEDGNPVYEHCSNVYKNSNLRFEIFDLR |
Enzyme Length | 223 |
Uniprot Accession Number | Q6NKP9 |
Absorption | |
Active Site | |
Activity Regulation | |
Binding Site | |
Calcium Binding | |
catalytic Activity | |
DNA Binding | |
EC Number | 3.4.19.- |
Enzyme Function | FUNCTION: Zinc metalloprotease that cleaves 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. {ECO:0000250}. |
Temperature Dependency | |
PH Dependency | |
Pathway | |
nucleotide Binding | |
Features | Alternative sequence (2); Chain (1); Domain (1); Erroneous gene model prediction (2); Metal binding (7); Motif (1); Site (1) |
Keywords | Alternative splicing;Hydrolase;Metal-binding;Metalloprotease;Protease;Reference proteome;Ubl conjugation pathway;Zinc |
Interact With | |
Induction | |
Subcellular Location | |
Modified Residue | |
Post Translational Modification | |
Signal Peptide | |
Structure 3D | |
Cross Reference PDB | - |
Mapped Pubmed ID | 14576160; 16934950; 23800962; |
Motif | MOTIF 127..140; /note=JAMM motif; /evidence=ECO:0000255|PROSITE-ProRule:PRU01182 |
Gene Encoded By | |
Mass | 24,939 |
Kinetics | |
Metal Binding | METAL 127; /note=Zinc 1; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU01182; METAL 129; /note=Zinc 1; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU01182; METAL 140; /note=Zinc 1; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU01182; METAL 142; /note=Zinc 2; /evidence=ECO:0000250; METAL 185; /note=Zinc 2; /evidence=ECO:0000250; METAL 191; /note=Zinc 2; /evidence=ECO:0000250; METAL 193; /note=Zinc 2; /evidence=ECO:0000250 |
Rhea ID | |
Cross Reference Brenda |