| IED ID | IndEnz0002016768 |
| Enzyme Type ID | protease016768 |
| Protein Name |
Antithrombin-III ATIII Serpin C1 |
| Gene Name | SERPINC1 AT3 PRO0309 |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MYSNVIGTVTSGKRKVYLLSLLLIGFWDCVTCHGSPVDICTAKPRDIPMNPMCIYRSPEKKATEDEGSEQKIPEATNRRVWELSKANSRFATTFYQHLADSKNDNDNIFLSPLSISTAFAMTKLGACNDTLQQLMEVFKFDTISEKTSDQIHFFFAKLNCRLYRKANKSSKLVSANRLFGDKSLTFNETYQDISELVYGAKLQPLDFKENAEQSRAAINKWVSNKTEGRITDVIPSEAINELTVLVLVNTIYFKGLWKSKFSPENTRKELFYKADGESCSASMMYQEGKFRYRRVAEGTQVLELPFKGDDITMVLILPKPEKSLAKVEKELTPEVLQEWLDELEEMMLVVHMPRFRIEDGFSLKEQLQDMGLVDLFSPEKSKLPGIVAEGRDDLYVSDAFHKAFLEVNEEGSEAAASTAVVIAGRSLNPNRVTFKANRPFLVFIREVPLNTIIFMGRVANPCVK |
| Enzyme Length | 464 |
| Uniprot Accession Number | P01008 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | BINDING 81; /note=Heparin; BINDING 161; /note=Heparin; BINDING 177; /note=Heparin |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin. {ECO:0000269|PubMed:15853774}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Beta strand (26); Binding site (3); Chain (1); Disulfide bond (3); Glycosylation (4); Helix (15); Modified residue (2); Mutagenesis (2); Natural variant (99); Sequence conflict (8); Signal peptide (1); Site (1); Turn (6) |
| Keywords | 3D-structure;Blood coagulation;Direct protein sequencing;Disease variant;Disulfide bond;Glycoprotein;Hemostasis;Heparin-binding;Phosphoprotein;Protease inhibitor;Reference proteome;Secreted;Serine protease inhibitor;Signal;Thrombophilia |
| Interact With | Q8IXL6; Itself; P00734; Itself |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted, extracellular space. |
| Modified Residue | MOD_RES 63; /note="Phosphothreonine; by FAM20C"; /evidence="ECO:0000269|PubMed:26091039"; MOD_RES 68; /note="Phosphoserine; by FAM20C"; /evidence="ECO:0000269|PubMed:26091039, ECO:0007744|PubMed:24275569" |
| Post Translational Modification | PTM: Phosphorylated by FAM20C in the extracellular medium. {ECO:0000269|PubMed:26091039}. |
| Signal Peptide | SIGNAL 1..32; /evidence=ECO:0000269|Ref.10 |
| Structure 3D | X-ray crystallography (27) |
| Cross Reference PDB | 1ANT; 1ATH; 1AZX; 1BR8; 1DZG; 1DZH; 1E03; 1E04; 1E05; 1JVQ; 1LK6; 1NQ9; 1OYH; 1R1L; 1SR5; 1T1F; 1TB6; 2ANT; 2B4X; 2B5T; 2BEH; 2GD4; 2HIJ; 2ZNH; 3EVJ; 3KCG; 4EB1; |
| Mapped Pubmed ID | 10781579; 10809774; 11686316; 11686319; 11754060; 11854268; 11861278; 12193972; 12369826; 12466122; 12556442; 12578831; 12581643; 12695507; 12873131; 12907439; 14532267; 14623882; 14652650; 14982929; 15140129; 15311268; 15311269; 15338392; 15342247; 15630490; 15630491; 15733967; 16619025; 16705712; 16796563; 16940049; 16973611; 17244682; 17413759; 17474147; 17492649; 17597998; 17849067; 18056677; 18208532; 18349091; 18550704; 18761717; 18923394; 18954896; 19004141; 19229049; 19277409; 19423540; 19452598; 19631608; 19715676; 19760264; 19762145; 19861246; 19913121; 19924026; 20024502; 20080729; 20088933; 2019570; 20224507; 20406964; 20438785; 20452482; 20628086; 20673868; 20683322; 21044781; 21240680; 21264449; 21316837; 21569219; 21569220; 21655678; 21795523; 21885952; 22116592; 22234719; 22353523; 22398878; 22424603; 22481271; 22627591; 22758787; 22918506; 22958499; 22997155; 23117546; 23329010; 23416531; 23429250; 23809926; 23844096; 24068708; 24072242; 24196373; 24226152; 24583439; 24966143; 2502206; 2505252; 25087890; 25298121; 25307422; 25312341; 25361738; 25483839; 25522812; 25771983; 25811371; 25851619; 26108065; 26177694; 26354831; 26581031; 26747427; 26748602; 26916305; 27003919; 27098529; 27161325; 27214821; 27222580; 27279637; 2742826; 27492143; 27708219; 27863268; 28174134; 28229161; 28274560; 28317092; 28361296; 28424376; 28607330; 2866798; 28783511; 28861852; 29112333; 29215785; 29564838; 30005274; 30458337; 3082357; 30896875; 30931675; 31030036; 31142255; 31157679; 3134349; 31441586; 31480053; 32151802; 32686144; 32745482; 32829961; 32865720; 32920809; 33179232; 33394380; 33419227; 34207366; 34324211; 34655467; 3744129; 8338946; 8735803; 8900153; 9405673; 9888880; |
| Motif | |
| Gene Encoded By | |
| Mass | 52,602 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |