Detail Information for IndEnz0002016768
IED ID IndEnz0002016768
Enzyme Type ID protease016768
Protein Name Antithrombin-III
ATIII
Serpin C1
Gene Name SERPINC1 AT3 PRO0309
Organism Homo sapiens (Human)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human)
Enzyme Sequence MYSNVIGTVTSGKRKVYLLSLLLIGFWDCVTCHGSPVDICTAKPRDIPMNPMCIYRSPEKKATEDEGSEQKIPEATNRRVWELSKANSRFATTFYQHLADSKNDNDNIFLSPLSISTAFAMTKLGACNDTLQQLMEVFKFDTISEKTSDQIHFFFAKLNCRLYRKANKSSKLVSANRLFGDKSLTFNETYQDISELVYGAKLQPLDFKENAEQSRAAINKWVSNKTEGRITDVIPSEAINELTVLVLVNTIYFKGLWKSKFSPENTRKELFYKADGESCSASMMYQEGKFRYRRVAEGTQVLELPFKGDDITMVLILPKPEKSLAKVEKELTPEVLQEWLDELEEMMLVVHMPRFRIEDGFSLKEQLQDMGLVDLFSPEKSKLPGIVAEGRDDLYVSDAFHKAFLEVNEEGSEAAASTAVVIAGRSLNPNRVTFKANRPFLVFIREVPLNTIIFMGRVANPCVK
Enzyme Length 464
Uniprot Accession Number P01008
Absorption
Active Site
Activity Regulation
Binding Site BINDING 81; /note=Heparin; BINDING 161; /note=Heparin; BINDING 177; /note=Heparin
Calcium Binding
catalytic Activity
DNA Binding
EC Number
Enzyme Function FUNCTION: Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin. {ECO:0000269|PubMed:15853774}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Beta strand (26); Binding site (3); Chain (1); Disulfide bond (3); Glycosylation (4); Helix (15); Modified residue (2); Mutagenesis (2); Natural variant (99); Sequence conflict (8); Signal peptide (1); Site (1); Turn (6)
Keywords 3D-structure;Blood coagulation;Direct protein sequencing;Disease variant;Disulfide bond;Glycoprotein;Hemostasis;Heparin-binding;Phosphoprotein;Protease inhibitor;Reference proteome;Secreted;Serine protease inhibitor;Signal;Thrombophilia
Interact With Q8IXL6; Itself; P00734; Itself
Induction
Subcellular Location SUBCELLULAR LOCATION: Secreted, extracellular space.
Modified Residue MOD_RES 63; /note="Phosphothreonine; by FAM20C"; /evidence="ECO:0000269|PubMed:26091039"; MOD_RES 68; /note="Phosphoserine; by FAM20C"; /evidence="ECO:0000269|PubMed:26091039, ECO:0007744|PubMed:24275569"
Post Translational Modification PTM: Phosphorylated by FAM20C in the extracellular medium. {ECO:0000269|PubMed:26091039}.
Signal Peptide SIGNAL 1..32; /evidence=ECO:0000269|Ref.10
Structure 3D X-ray crystallography (27)
Cross Reference PDB 1ANT; 1ATH; 1AZX; 1BR8; 1DZG; 1DZH; 1E03; 1E04; 1E05; 1JVQ; 1LK6; 1NQ9; 1OYH; 1R1L; 1SR5; 1T1F; 1TB6; 2ANT; 2B4X; 2B5T; 2BEH; 2GD4; 2HIJ; 2ZNH; 3EVJ; 3KCG; 4EB1;
Mapped Pubmed ID 10781579; 10809774; 11686316; 11686319; 11754060; 11854268; 11861278; 12193972; 12369826; 12466122; 12556442; 12578831; 12581643; 12695507; 12873131; 12907439; 14532267; 14623882; 14652650; 14982929; 15140129; 15311268; 15311269; 15338392; 15342247; 15630490; 15630491; 15733967; 16619025; 16705712; 16796563; 16940049; 16973611; 17244682; 17413759; 17474147; 17492649; 17597998; 17849067; 18056677; 18208532; 18349091; 18550704; 18761717; 18923394; 18954896; 19004141; 19229049; 19277409; 19423540; 19452598; 19631608; 19715676; 19760264; 19762145; 19861246; 19913121; 19924026; 20024502; 20080729; 20088933; 2019570; 20224507; 20406964; 20438785; 20452482; 20628086; 20673868; 20683322; 21044781; 21240680; 21264449; 21316837; 21569219; 21569220; 21655678; 21795523; 21885952; 22116592; 22234719; 22353523; 22398878; 22424603; 22481271; 22627591; 22758787; 22918506; 22958499; 22997155; 23117546; 23329010; 23416531; 23429250; 23809926; 23844096; 24068708; 24072242; 24196373; 24226152; 24583439; 24966143; 2502206; 2505252; 25087890; 25298121; 25307422; 25312341; 25361738; 25483839; 25522812; 25771983; 25811371; 25851619; 26108065; 26177694; 26354831; 26581031; 26747427; 26748602; 26916305; 27003919; 27098529; 27161325; 27214821; 27222580; 27279637; 2742826; 27492143; 27708219; 27863268; 28174134; 28229161; 28274560; 28317092; 28361296; 28424376; 28607330; 2866798; 28783511; 28861852; 29112333; 29215785; 29564838; 30005274; 30458337; 3082357; 30896875; 30931675; 31030036; 31142255; 31157679; 3134349; 31441586; 31480053; 32151802; 32686144; 32745482; 32829961; 32865720; 32920809; 33179232; 33394380; 33419227; 34207366; 34324211; 34655467; 3744129; 8338946; 8735803; 8900153; 9405673; 9888880;
Motif
Gene Encoded By
Mass 52,602
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda