Detail Information for IndEnz0002016772
IED ID IndEnz0002016772
Enzyme Type ID protease016772
Protein Name Angiopoietin-related protein 7
Angiopoietin-like factor
Angiopoietin-like protein 7
Cornea-derived transcript 6 protein
Gene Name ANGPTL7 CDT6 UNQ313/PRO356
Organism Homo sapiens (Human)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human)
Enzyme Sequence MLKKPLSAVTWLCIFIVAFVSHPAWLQKLSKHKTPAQPQLKAANCCEEVKELKAQVANLSSLLSELNKKQERDWVSVVMQVMELESNSKRMESRLTDAESKYSEMNNQIDIMQLQAAQTVTQTSADAIYDCSSLYQKNYRISGVYKLPPDDFLGSPELEVFCDMETSGGGWTIIQRRKSGLVSFYRDWKQYKQGFGSIRGDFWLGNEHIHRLSRQPTRLRVEMEDWEGNLRYAEYSHFVLGNELNSYRLFLGNYTGNVGNDALQYHNNTAFSTKDKDNDNCLDKCAQLRKGGYWYNCCTDSNLNGVYYRLGEHNKHLDGITWYGWHGSTYSLKRVEMKIRPEDFKP
Enzyme Length 346
Uniprot Accession Number O43827
Absorption
Active Site
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number
Enzyme Function FUNCTION: Has a role in the formation and organization of the extracellular matrix. In the eye, it functions as a mediator of dexamethasone-induced matrix deposition in the trabecular meshwork, the tissue responsible for the outflow of the ocular aqueous humor and for the maintenance of intraocular pressure (PubMed:21199193). Is a negative regulator of angiogenesis in the cornea, and plays a major role in maintaining corneal avascularity and transparency (PubMed:25622036). {ECO:0000269|PubMed:21199193, ECO:0000269|PubMed:25622036}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Chain (1); Coiled coil (1); Disulfide bond (2); Domain (1); Glycosylation (3); Natural variant (3); Signal peptide (1)
Keywords Coiled coil;Direct protein sequencing;Disulfide bond;Glycoprotein;Reference proteome;Secreted;Signal
Interact With P35609
Induction INDUCTION: Expression is up-regulated by dexamethasone. {ECO:0000269|PubMed:16541013}.
Subcellular Location SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11682471}.
Modified Residue
Post Translational Modification
Signal Peptide SIGNAL 1..26; /evidence=ECO:0000269|PubMed:15340161
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID 18421092; 24903490; 25854806; 28264047; 31302653; 31962333; 32369491; 32525822; 32786125; 33313310;
Motif
Gene Encoded By
Mass 40,018
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda