Detail Information for IndEnz0002016773
IED ID IndEnz0002016773
Enzyme Type ID protease016773
Protein Name Astacin-like metalloendopeptidase
EC 3.4.-.-
Gene Name ASTL
Organism Gallus gallus (Chicken)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Sauropsida Sauria (diapsids) Archelosauria Archosauria Dinosauria Saurischia Theropoda Coelurosauria Aves Neognathae Galloanserae Galliformes Phasianidae (turkeys) Phasianinae Gallus Gallus gallus (Chicken)
Enzyme Sequence MDLKMLLIFIAFLLPSVLGFPIQDNYENSTATTESTQVTTEEDIYDSPSPAETDSEDELIFNRILEVNKDSSQYLQEGDIVPRRSRSAINCRNCYWPQSRDGIVRIPYVLDPTYEENHVKGIREAMAEFETLTCINFVKRKTERDYLIIRSADGCWSNYGKVGGGQTISVMKGGCMWKGIIQHELDHALGFLHEHSRSDRDKYVRIMWEYISPADRPDFKKFENSNNLGLPYDYSSVMHYGPHTFTNTTGKATIVPVPDGSVHIGQRLGLSNLDVAKINRLYNCSRCSTIIDAAFGSLKSANYPRNYSDNTNCVWLIRTRSRKISLHFRAFELRTTRGCQGDYVKVYDGSSKYSTVLMDKTCGSQIPTDVVSSSNLMLIEFVTDGADTASGFQATFTSAKIQRRFKIRN
Enzyme Length 409
Uniprot Accession Number P0DJJ2
Absorption
Active Site ACT_SITE 184; /evidence=ECO:0000255|PROSITE-ProRule:PRU01211
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number 3.4.-.-
Enzyme Function FUNCTION: Probable oocyte-specific oolemmal receptor involved in sperm and egg adhesion and fertilization. May act as a protease (By similarity). {ECO:0000250}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (1); Chain (1); Compositional bias (1); Disulfide bond (5); Domain (2); Metal binding (3); Region (1); Signal peptide (1)
Keywords Cell membrane;Cytoplasm;Cytoplasmic vesicle;Disulfide bond;Fertilization;Hydrolase;Membrane;Metal-binding;Metalloprotease;Protease;Reference proteome;Signal;Zinc;Zymogen
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q6HA09}. Cell membrane {ECO:0000250|UniProtKB:Q6HA09}. Cytoplasmic vesicle, secretory vesicle, Cortical granule {ECO:0000250|UniProtKB:Q6HA09}.
Modified Residue
Post Translational Modification
Signal Peptide SIGNAL 1..19; /evidence=ECO:0000255
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 46,388
Kinetics
Metal Binding METAL 183; /note=Zinc; via tele nitrogen; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU01211; METAL 187; /note=Zinc; via tele nitrogen; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU01211; METAL 193; /note=Zinc; via tele nitrogen; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU01211
Rhea ID
Cross Reference Brenda