IED ID | IndEnz0002016775 |
Enzyme Type ID | protease016775 |
Protein Name |
Probable metalloprotease ARX1 EC 3.-.-.- Associated with ribosomal export complex protein 1 |
Gene Name | ARX1 YDR101C YD8557.10c |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Saccharomycotina (true yeasts) Saccharomycetes Saccharomycetales Saccharomycetaceae Saccharomyces Saccharomyces cerevisiae (Baker's yeast) Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Enzyme Sequence | MALAISHEDTQILLKDKNILQESVLNKYRTAGQIAQTALKYVTSLINDSYHSKTTQRQLTVPELCLLTDSFILTRLEQYYKNKVNERGIAIPTTIDIDQISGGWCPEIDDTQNLLNWNKGKDSTFASSVTGTLRPGDLVKITLGVHIDGYTSEVSHTMVIYPVDETKPILQPTGPLLGGKADAVAAAHIAMETVVALLACALTPEKLPASLGGTSSGITGQLIRTIVDTIARSYNCGVVPGSRVRRIRRFLAGQNEGIVAEREYKGVVWTESHQEADLLSNTDAKDLTVVDRGQSTPFTNVSAIPSDDFVVQSGEVYLIDLKMASLEHCTKKGLVTLETVDSYTGKSHKAGELIARPGAYVRDFAQTHILKLKTSRQLLTKIDKQGVYPFKLSHLSSNFPFVHENEEELQSLKKDLKSFRLGMSEISNNYLCVESPIQIARWVPWDHILKATNPNGNLSYDATSTLTLPGHELPLPKLGVSAIKLKSLMNSTKESISLPVARECNTIVLCDSSVSTTDRPELLRLTGGSKTCQPSWIHSQHELNPQDSIVQGIFQLATLAKDKRFGLLLKETQPMKQKSVETSNGGVEETMKM |
Enzyme Length | 593 |
Uniprot Accession Number | Q03862 |
Absorption | |
Active Site | |
Activity Regulation | |
Binding Site | |
Calcium Binding | |
catalytic Activity | |
DNA Binding | |
EC Number | 3.-.-.- |
Enzyme Function | FUNCTION: Probable metalloprotease involved in proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit. Accompanies the pre-60S particles to the cytoplasm. {ECO:0000269|PubMed:12374754, ECO:0000269|PubMed:16648468}. |
Temperature Dependency | |
PH Dependency | |
Pathway | |
nucleotide Binding | |
Features | Chain (1) |
Keywords | 3D-structure;Cytoplasm;Hydrolase;Metal-binding;Metalloprotease;Nucleus;Protease;Reference proteome |
Interact With | P47019; Q12080; P38344 |
Induction | |
Subcellular Location | SUBCELLULAR LOCATION: Cytoplasm. Nucleus. |
Modified Residue | |
Post Translational Modification | |
Signal Peptide | |
Structure 3D | Electron microscopy (11) |
Cross Reference PDB | 3JCT; 4V7F; 4V8T; 5APN; 5APO; 5JCS; 6FT6; 6M62; 6RZZ; 6YLG; 6YLH; |
Mapped Pubmed ID | 11805826; 11805837; 12957375; 14690591; 15120992; 15556036; 16227579; 16429126; 16554755; 16651379; 17242366; 17509569; 17652132; 17786152; 17803941; 18077551; 18467557; 18658244; 19144820; 19433447; 19536198; 19737519; 19879902; 19901025; 20100801; 20348449; 20419146; 20670889; 21048991; 21772262; 21852791; 22419078; 22550233; 22893726; 23045392; 23142978; 23142985; 23212245; 23706744; 23788678; 23874617; 24172536; 24190922; 24240281; 24312670; 24603461; 24662372; 25802992; 25877921; 26619264; 26709046; 27036125; 27251291; 27693354; 27775710; 29519915; 31115337; 32668200; 32719344; |
Motif | |
Gene Encoded By | |
Mass | 65,213 |
Kinetics | |
Metal Binding | |
Rhea ID | |
Cross Reference Brenda |