| IED ID | IndEnz0002016775 |
| Enzyme Type ID | protease016775 |
| Protein Name |
Probable metalloprotease ARX1 EC 3.-.-.- Associated with ribosomal export complex protein 1 |
| Gene Name | ARX1 YDR101C YD8557.10c |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Saccharomycotina (true yeasts) Saccharomycetes Saccharomycetales Saccharomycetaceae Saccharomyces Saccharomyces cerevisiae (Baker's yeast) Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
| Enzyme Sequence | MALAISHEDTQILLKDKNILQESVLNKYRTAGQIAQTALKYVTSLINDSYHSKTTQRQLTVPELCLLTDSFILTRLEQYYKNKVNERGIAIPTTIDIDQISGGWCPEIDDTQNLLNWNKGKDSTFASSVTGTLRPGDLVKITLGVHIDGYTSEVSHTMVIYPVDETKPILQPTGPLLGGKADAVAAAHIAMETVVALLACALTPEKLPASLGGTSSGITGQLIRTIVDTIARSYNCGVVPGSRVRRIRRFLAGQNEGIVAEREYKGVVWTESHQEADLLSNTDAKDLTVVDRGQSTPFTNVSAIPSDDFVVQSGEVYLIDLKMASLEHCTKKGLVTLETVDSYTGKSHKAGELIARPGAYVRDFAQTHILKLKTSRQLLTKIDKQGVYPFKLSHLSSNFPFVHENEEELQSLKKDLKSFRLGMSEISNNYLCVESPIQIARWVPWDHILKATNPNGNLSYDATSTLTLPGHELPLPKLGVSAIKLKSLMNSTKESISLPVARECNTIVLCDSSVSTTDRPELLRLTGGSKTCQPSWIHSQHELNPQDSIVQGIFQLATLAKDKRFGLLLKETQPMKQKSVETSNGGVEETMKM |
| Enzyme Length | 593 |
| Uniprot Accession Number | Q03862 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.-.-.- |
| Enzyme Function | FUNCTION: Probable metalloprotease involved in proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit. Accompanies the pre-60S particles to the cytoplasm. {ECO:0000269|PubMed:12374754, ECO:0000269|PubMed:16648468}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1) |
| Keywords | 3D-structure;Cytoplasm;Hydrolase;Metal-binding;Metalloprotease;Nucleus;Protease;Reference proteome |
| Interact With | P47019; Q12080; P38344 |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cytoplasm. Nucleus. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | Electron microscopy (11) |
| Cross Reference PDB | 3JCT; 4V7F; 4V8T; 5APN; 5APO; 5JCS; 6FT6; 6M62; 6RZZ; 6YLG; 6YLH; |
| Mapped Pubmed ID | 11805826; 11805837; 12957375; 14690591; 15120992; 15556036; 16227579; 16429126; 16554755; 16651379; 17242366; 17509569; 17652132; 17786152; 17803941; 18077551; 18467557; 18658244; 19144820; 19433447; 19536198; 19737519; 19879902; 19901025; 20100801; 20348449; 20419146; 20670889; 21048991; 21772262; 21852791; 22419078; 22550233; 22893726; 23045392; 23142978; 23142985; 23212245; 23706744; 23788678; 23874617; 24172536; 24190922; 24240281; 24312670; 24603461; 24662372; 25802992; 25877921; 26619264; 26709046; 27036125; 27251291; 27693354; 27775710; 29519915; 31115337; 32668200; 32719344; |
| Motif | |
| Gene Encoded By | |
| Mass | 65,213 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |