| IED ID | IndEnz0002016777 |
| Enzyme Type ID | protease016777 |
| Protein Name |
Aspartic protease 4 EC 3.4.23.- |
| Gene Name | asp-4 R12H7.2 |
| Organism | Caenorhabditis elegans |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Nematoda (roundworms) Chromadorea Rhabditida Rhabditina Rhabditomorpha Rhabditoidea Rhabditidae Peloderinae Caenorhabditis Caenorhabditis elegans |
| Enzyme Sequence | MNRCILLLLGALLLVQGLHVHKRQQKLRTVSLKKQPTLRETLLQAGSFETFAKHRHGYKKYLKTNGNHHFDKYQALNVEGEIDELLRNYMDAQYFGTISIGTPAQNFTVIFDTGSSNLWIPSKKCPFYDIACMLHHRYDSKSSSTYKEDGRKMAIQYGTGSMKGFISKDSVCVAGVCAEDQPFAEATSEPGITFVAAKFDGILGMAYPEIAVLGVQPVFNTLFEQKKVPSNLFSFWLNRNPDSEIGGEITFGGIDSRRYVEPITYVPVTRKGYWQFKMDKVVGSGVLGCSNGCQAIADTGTSLIAGPKAQIEAIQNFIGAEPLIKGEYMISCDKVPTLPPVSFVIGGQEFSLKGEDYVLKVSQGGKTICLSGFMGIDLPERVGELWILGDVFIGRYYSVFDFDQNRVGFAQAKTADGRPVDPAPRPFRSVFDNESEESMEQDDE |
| Enzyme Length | 444 |
| Uniprot Accession Number | Q21966 |
| Absorption | |
| Active Site | ACT_SITE 112; /evidence=ECO:0000255|PROSITE-ProRule:PRU01103; ACT_SITE 298; /evidence=ECO:0000255|PROSITE-ProRule:PRU01103 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.23.- |
| Enzyme Function | FUNCTION: Aspartic protease, which is part of the necrosis cell death pathway (PubMed:12410314). Involved in neuronal cell degeneration (PubMed:12410314). Involved in heat stress response (PubMed:26795495). {ECO:0000269|PubMed:12410314, ECO:0000269|PubMed:26795495}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Chain (1); Disulfide bond (3); Domain (1); Glycosylation (2); Region (1); Signal peptide (1) |
| Keywords | Aspartyl protease;Cytoplasm;Disulfide bond;Glycoprotein;Hydrolase;Lysosome;Necrosis;Protease;Reference proteome;Secreted;Signal |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12410314}. Lysosome {ECO:0000269|PubMed:12410314}. Secreted {ECO:0000305}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..17; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 12097347; 16636145; 17164286; 17889653; 17901876; 18182484; 19021916; 19343510; 21177967; 21673804; 22347378; 22560298; 23800452; 24258276; 25487147; 26351692; 26952210; 27457958; 27506200; 29348603; 30036395; 30807579; |
| Motif | |
| Gene Encoded By | |
| Mass | 49,277 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |