IED ID | IndEnz0002016777 |
Enzyme Type ID | protease016777 |
Protein Name |
Aspartic protease 4 EC 3.4.23.- |
Gene Name | asp-4 R12H7.2 |
Organism | Caenorhabditis elegans |
Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Nematoda (roundworms) Chromadorea Rhabditida Rhabditina Rhabditomorpha Rhabditoidea Rhabditidae Peloderinae Caenorhabditis Caenorhabditis elegans |
Enzyme Sequence | MNRCILLLLGALLLVQGLHVHKRQQKLRTVSLKKQPTLRETLLQAGSFETFAKHRHGYKKYLKTNGNHHFDKYQALNVEGEIDELLRNYMDAQYFGTISIGTPAQNFTVIFDTGSSNLWIPSKKCPFYDIACMLHHRYDSKSSSTYKEDGRKMAIQYGTGSMKGFISKDSVCVAGVCAEDQPFAEATSEPGITFVAAKFDGILGMAYPEIAVLGVQPVFNTLFEQKKVPSNLFSFWLNRNPDSEIGGEITFGGIDSRRYVEPITYVPVTRKGYWQFKMDKVVGSGVLGCSNGCQAIADTGTSLIAGPKAQIEAIQNFIGAEPLIKGEYMISCDKVPTLPPVSFVIGGQEFSLKGEDYVLKVSQGGKTICLSGFMGIDLPERVGELWILGDVFIGRYYSVFDFDQNRVGFAQAKTADGRPVDPAPRPFRSVFDNESEESMEQDDE |
Enzyme Length | 444 |
Uniprot Accession Number | Q21966 |
Absorption | |
Active Site | ACT_SITE 112; /evidence=ECO:0000255|PROSITE-ProRule:PRU01103; ACT_SITE 298; /evidence=ECO:0000255|PROSITE-ProRule:PRU01103 |
Activity Regulation | |
Binding Site | |
Calcium Binding | |
catalytic Activity | |
DNA Binding | |
EC Number | 3.4.23.- |
Enzyme Function | FUNCTION: Aspartic protease, which is part of the necrosis cell death pathway (PubMed:12410314). Involved in neuronal cell degeneration (PubMed:12410314). Involved in heat stress response (PubMed:26795495). {ECO:0000269|PubMed:12410314, ECO:0000269|PubMed:26795495}. |
Temperature Dependency | |
PH Dependency | |
Pathway | |
nucleotide Binding | |
Features | Active site (2); Chain (1); Disulfide bond (3); Domain (1); Glycosylation (2); Region (1); Signal peptide (1) |
Keywords | Aspartyl protease;Cytoplasm;Disulfide bond;Glycoprotein;Hydrolase;Lysosome;Necrosis;Protease;Reference proteome;Secreted;Signal |
Interact With | |
Induction | |
Subcellular Location | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12410314}. Lysosome {ECO:0000269|PubMed:12410314}. Secreted {ECO:0000305}. |
Modified Residue | |
Post Translational Modification | |
Signal Peptide | SIGNAL 1..17; /evidence=ECO:0000255 |
Structure 3D | |
Cross Reference PDB | - |
Mapped Pubmed ID | 12097347; 16636145; 17164286; 17889653; 17901876; 18182484; 19021916; 19343510; 21177967; 21673804; 22347378; 22560298; 23800452; 24258276; 25487147; 26351692; 26952210; 27457958; 27506200; 29348603; 30036395; 30807579; |
Motif | |
Gene Encoded By | |
Mass | 49,277 |
Kinetics | |
Metal Binding | |
Rhea ID | |
Cross Reference Brenda |