Detail Information for IndEnz0002016813
IED ID IndEnz0002016813
Enzyme Type ID protease016813
Protein Name Chaperone protein ClpB
Gene Name clpB
Organism Dichelobacter nodosus (Bacteroides nodosus)
Taxonomic Lineage cellular organisms Bacteria Proteobacteria Gammaproteobacteria Cardiobacteriales Cardiobacteriaceae Dichelobacter Dichelobacter nodosus (Bacteroides nodosus)
Enzyme Sequence MEFMQMSKKFTARFQEALSAAQSLAVGKDHAYIEPLHIFSALLDQEGSSIIAIAQRAGGQIGAVRQAVMQALERLPRVKNPTGDVNISPESMRLLNLCDKYAQQNGDEYISSELFLRAVYDAKGDLEQLLRANGLEKAAVVAAIDAVRGGEAVTDEYAEDKRGALKKYTLDVTQRPLDGKIDPVIGRDEEIRRAMQILQRRSKNNPVLIGEPGVGKTAIVEGLAQRIADRAVPESLKGKRLLSLDLAALLAGTKYRGEFEERLKAVLDEITKADGQIILFIDEIHTMVGAGKSEGSLDAGNMLKPALARGDLHCIGATTLDEYRQYMEKDAALERRFQKVIVDEPSVEDTIAILRNLQERYEVHHGINITDPALVAAAQLSHRYISGRKLPDKAIDLMDEAAAQIRMELDSKPEVMDKIDRRLIQLQIERMALEKETDAASKRRLSDLEAEIAAQEKEYADLEEIWLAEKAGNAGAAEIKEQLDKLRVELEAAKRRGDFARASEIQYGLIPAKEKQLLENEQQTEQRPHRLMRNKVTAEEIAEIVSRWTGIPVAKMMEGEKERLLHLETVLNERVVGQKTAVEAVANAIRRNRAGLSDPKRPIGSFLFLGPTGVGKTELCRTLAQFLFDSEENMVRIDMSEFMEKHSVARLIGAPPGYVGYDQGGYLTEAVRRKPYSVVLFDEVEKAHSDVFNTLLQVLDEGRLTDGQGRTVDFRHTVIIMTSNLGSDMIQLLAEKSYEEMKSAVMEIVMAHFRPEFINRIDEAIVFHGLAKTHMYRIAQIQLERLRQRLQTRELLLSVEEDAINQLVELGYDPLFGARPLKRAIQNYIENPLAQALLAGQYLPQSTITIGFDGTNFTFH
Enzyme Length 860
Uniprot Accession Number P17422
Absorption
Active Site
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number
Enzyme Function FUNCTION: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity). {ECO:0000250}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding NP_BIND 210..217; /note=ATP 1; /evidence=ECO:0000250; NP_BIND 610..617; /note=ATP 2; /evidence=ECO:0000250
Features Chain (1); Coiled coil (1); Domain (1); Nucleotide binding (2); Region (6)
Keywords ATP-binding;Chaperone;Coiled coil;Cytoplasm;Nucleotide-binding;Repeat;Stress response
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
Modified Residue
Post Translational Modification
Signal Peptide
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 96,271
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda