IED ID |
IndEnz0002016914 |
Enzyme Type ID |
protease016914 |
Protein Name |
ATP-dependent Clp protease ATP-binding subunit ClpC1
|
Gene Name |
clpC1 Rv3596c MTCY07H7B.26 |
Organism |
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
Taxonomic Lineage |
cellular organisms
Bacteria
Terrabacteria group
Actinobacteria
Actinomycetia (high G+C Gram-positive bacteria)
Corynebacteriales
Mycobacteriaceae
Mycobacterium
Mycobacterium tuberculosis complex
Mycobacterium tuberculosis
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
|
Enzyme Sequence |
MFERFTDRARRVVVLAQEEARMLNHNYIGTEHILLGLIHEGEGVAAKSLESLGISLEGVRSQVEEIIGQGQQAPSGHIPFTPRAKKVLELSLREALQLGHNYIGTEHILLGLIREGEGVAAQVLVKLGAELTRVRQQVIQLLSGYQGKEAAEAGTGGRGGESGSPSTSLVLDQFGRNLTAAAMEGKLDPVIGREKEIERVMQVLSRRTKNNPVLIGEPGVGKTAVVEGLAQAIVHGEVPETLKDKQLYTLDLGSLVAGSRYRGDFEERLKKVLKEINTRGDIILFIDELHTLVGAGAAEGAIDAASILKPKLARGELQTIGATTLDEYRKYIEKDAALERRFQPVQVGEPTVEHTIEILKGLRDRYEAHHRVSITDAAMVAAATLADRYINDRFLPDKAIDLIDEAGARMRIRRMTAPPDLREFDEKIAEARREKESAIDAQDFEKAASLRDREKTLVAQRAEREKQWRSGDLDVVAEVDDEQIAEVLGNWTGIPVFKLTEAETTRLLRMEEELHKRIIGQEDAVKAVSKAIRRTRAGLKDPKRPSGSFIFAGPSGVGKTELSKALANFLFGDDDALIQIDMGEFHDRFTASRLFGAPPGYVGYEEGGQLTEKVRRKPFSVVLFDEIEKAHQEIYNSLLQVLEDGRLTDGQGRTVDFKNTVLIFTSNLGTSDISKPVGLGFSKGGGENDYERMKQKVNDELKKHFRPEFLNRIDDIIVFHQLTREEIIRMVDLMISRVAGQLKSKDMALVLTDAAKALLAKRGFDPVLGARPLRRTIQREIEDQLSEKILFEEVGPGQVVTVDVDNWDGEGPGEDAVFTFTGTRKPPAEPDLAKAGAHSAGGPEPAAR |
Enzyme Length |
848 |
Uniprot Accession Number |
P9WPC9 |
Absorption |
|
Active Site |
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Activity Regulation |
|
Binding Site |
|
Calcium Binding |
|
catalytic Activity |
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DNA Binding |
|
EC Number |
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Enzyme Function |
FUNCTION: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity). Degrades anti-sigma-E factor RseA in the presence of ClpP2. {ECO:0000250, ECO:0000269|PubMed:20025669}. |
Temperature Dependency |
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PH Dependency |
|
Pathway |
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nucleotide Binding |
NP_BIND 216..223; /note=ATP; /evidence=ECO:0000255; NP_BIND 553..560; /note=ATP; /evidence=ECO:0000255 |
Features |
Beta strand (2); Chain (1); Domain (2); Helix (9); Nucleotide binding (2); Region (5); Turn (1) |
Keywords |
3D-structure;ATP-binding;Chaperone;Nucleotide-binding;Reference proteome;Repeat |
Interact With |
P9WNK5 |
Induction |
|
Subcellular Location |
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Modified Residue |
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Post Translational Modification |
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Signal Peptide |
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Structure 3D |
X-ray crystallography (9) |
Cross Reference PDB |
3WDB;
3WDC;
3WDD;
3WDE;
6CN8;
6PBA;
6PBQ;
6PBS;
6UCR;
|
Mapped Pubmed ID |
16844784;
24022489;
30990022;
32355042;
|
Motif |
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Gene Encoded By |
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Mass |
93,552 |
Kinetics |
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Metal Binding |
|
Rhea ID |
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Cross Reference Brenda |
3.4.21.92; |