Detail Information for IndEnz0002016949
IED ID IndEnz0002016949
Enzyme Type ID protease016949
Protein Name ATP-dependent Clp protease ATP-binding subunit ClpC
Gene Name clpC SAOUHSC_00505
Organism Staphylococcus aureus (strain NCTC 8325 / PS 47)
Taxonomic Lineage cellular organisms Bacteria Terrabacteria group Firmicutes Bacilli Bacillales Staphylococcaceae Staphylococcus Staphylococcus aureus Staphylococcus aureus (strain NCTC 8325 / PS 47)
Enzyme Sequence MLFGRLTERAQRVLAHAQEEAIRLNHSNIGTEHLLLGLMKEPEGIAAKVLESFNITEDKVIEEVEKLIGHGQDHVGTLHYTPRAKKVIELSMDEARKLHHNFVGTEHILLGLIRENEGVAARVFANLDLNITKARAQVVKALGNPEMSNKNAQASKSNNTPTLDSLARDLTVIAKDGTLDPVIGRDKEITRVIEVLSRRTKNNPVLIGEPGVGKTAIAEGLAQAIVNNEVPETLKDKRVMSLDMGTVVAGTKYRGEFEERLKKVMEEIQQAGNVILFIDELHTLVGAGGAEGAIDASNILKPALARGELQCIGATTLDEYRKNIEKDAALERRFQPVQVDEPSVVDTVAILKGLRDRYEAHHRINISDEAIEAAVKLSNRYVSDRFLPDKAIDLIDEASSKVRLKSHTTPNNLKEIEQEIEKVKNEKDAAVHAQEFENAANLRDKQTKLEKQYEEAKNEWKNAQNGMSTSLSEEDIAEVIAGWTGIPLTKINETESEKLLSLEDTLHERVIGQKDAVNSISKAVRRARAGLKDPKRPIGSFIFLGPTGVGKTELARALAESMFGDDDAMIRVDMSEFMEKHAVSRLVGAPPGYVGHDDGGQLTEKVRRKPYSVILFDEIEKAHPDVFNILLQVLDDGHLTDTKGRTVDFRNTIIIMTSNVGAQELQDQRFAGFGGSSDGQDYETIRKTMLKELKNSFRPEFLNRVDDIIVFHKLTKEELKEIVTMMVNKLTNRLSEQNINIIVTDKAKDKIAEEGYDPEYGARPLIRAIQKTIEDNLSELILDGNQIEGKKVTVDHDGKEFKYDIAEQTSETKTPSQA
Enzyme Length 818
Uniprot Accession Number Q2G0P5
Absorption
Active Site
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number
Enzyme Function FUNCTION: Required for growth at high temperatures, probably by acting as a chaperone during heat shock and targeting heat-denatured proteins for degradation by ClpP. Required for biofilm formation. May act as a chaperone regulating CtsR activity. {ECO:0000269|PubMed:15554981}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding NP_BIND 208..215; /note=ATP; /evidence=ECO:0000255; NP_BIND 545..552; /note=ATP; /evidence=ECO:0000255
Features Chain (1); Domain (2); Nucleotide binding (2); Region (4)
Keywords 3D-structure;ATP-binding;Chaperone;Nucleotide-binding;Reference proteome;Repeat;Stress response;Virulence
Interact With
Induction INDUCTION: By heat shock. Transcriptionally regulated by CtsR (PubMed:15554981). Up-regulated by heavy metals such as Cu(2+) and Cd(2+), but Zn(2+) and Co(2+) have no effect (PubMed:22126623). Forms part of an operon with ctsR, mcsA and mcsB. {ECO:0000269|PubMed:15554981, ECO:0000269|PubMed:22126623}.
Subcellular Location
Modified Residue
Post Translational Modification
Signal Peptide
Structure 3D Electron microscopy (1)
Cross Reference PDB 6EM8;
Mapped Pubmed ID 29165246;
Motif
Gene Encoded By
Mass 91,037
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda