| IED ID | IndEnz0002017054 |
| Enzyme Type ID | protease017054 |
| Protein Name |
Collagen alpha-2 I chain Alpha-2 type I collagen |
| Gene Name | COL1A2 |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MLSFVDTRTLLLLAVTLCLATCQSLQEETVRKGPAGDRGPRGERGPPGPPGRDGEDGPTGPPGPPGPPGPPGLGGNFAAQYDGKGVGLGPGPMGLMGPRGPPGAAGAPGPQGFQGPAGEPGEPGQTGPAGARGPAGPPGKAGEDGHPGKPGRPGERGVVGPQGARGFPGTPGLPGFKGIRGHNGLDGLKGQPGAPGVKGEPGAPGENGTPGQTGARGLPGERGRVGAPGPAGARGSDGSVGPVGPAGPIGSAGPPGFPGAPGPKGEIGAVGNAGPAGPAGPRGEVGLPGLSGPVGPPGNPGANGLTGAKGAAGLPGVAGAPGLPGPRGIPGPVGAAGATGARGLVGEPGPAGSKGESGNKGEPGSAGPQGPPGPSGEEGKRGPNGEAGSAGPPGPPGLRGSPGSRGLPGADGRAGVMGPPGSRGASGPAGVRGPNGDAGRPGEPGLMGPRGLPGSPGNIGPAGKEGPVGLPGIDGRPGPIGPAGARGEPGNIGFPGPKGPTGDPGKNGDKGHAGLAGARGAPGPDGNNGAQGPPGPQGVQGGKGEQGPPGPPGFQGLPGPSGPAGEVGKPGERGLHGEFGLPGPAGPRGERGPPGESGAAGPTGPIGSRGPSGPPGPDGNKGEPGVVGAVGTAGPSGPSGLPGERGAAGIPGGKGEKGEPGLRGEIGNPGRDGARGAPGAVGAPGPAGATGDRGEAGAAGPAGPAGPRGSPGERGEVGPAGPNGFAGPAGAAGQPGAKGERGAKGPKGENGVVGPTGPVGAAGPAGPNGPPGPAGSRGDGGPPGMTGFPGAAGRTGPPGPSGISGPPGPPGPAGKEGLRGPRGDQGPVGRTGEVGAVGPPGFAGEKGPSGEAGTAGPPGTPGPQGLLGAPGILGLPGSRGERGLPGVAGAVGEPGPLGIAGPPGARGPPGAVGSPGVNGAPGEAGRDGNPGNDGPPGRDGQPGHKGERGYPGNIGPVGAAGAPGPHGPVGPAGKHGNRGETGPSGPVGPAGAVGPRGPSGPQGIRGDKGEPGEKGPRGLPGLKGHNGLQGLPGIAGHHGDQGAPGSVGPAGPRGPAGPSGPAGKDGRTGHPGTVGPAGIRGPQGHQGPAGPPGPPGPPGPPGVSGGGYDFGYDGDFYRADQPRSAPSLRPKDYEVDATLKSLNNQIETLLTPEGSRKNPARTCRDLRLSHPEWSSGYYWIDPNQGCTMDAIKVYCDFSTGETCIRAQPENIPAKNWYRSSKDKKHVWLGETINAGSQFEYNVEGVTSKEMATQLAFMRLLANYASQNITYHCKNSIAYMDEETGNLKKAVILQGSNDVELVAEGNSRFTYTVLVDGCSKKTNEWGKTIIEYKTNKPSRLPFLDIAPLDIGGADQEFFVDIGPVCFK |
| Enzyme Length | 1366 |
| Uniprot Accession Number | P08123 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Type I collagen is a member of group I collagen (fibrillar forming collagen). |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Compositional bias (3); Disulfide bond (3); Domain (1); Glycosylation (2); Metal binding (5); Modified residue (15); Natural variant (113); Propeptide (2); Region (1); Sequence conflict (11); Signal peptide (1) |
| Keywords | 3D-structure;Calcium;Chromosomal rearrangement;Collagen;Direct protein sequencing;Disease variant;Disulfide bond;Dwarfism;Ehlers-Danlos syndrome;Extracellular matrix;Glycoprotein;Hydroxylation;Metal-binding;Osteogenesis imperfecta;Pyrrolidone carboxylic acid;Reference proteome;Repeat;Secreted;Signal |
| Interact With | P02452; O00303; Q6PIL6; Q14696; O43765; Q96EQ0; Q96GM5; Q9UMX0; Q9UMX0-2; Q9UHD9 |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000255|PROSITE-ProRule:PRU00793}. |
| Modified Residue | MOD_RES 23; /note="Pyrrolidone carboxylic acid"; /evidence="ECO:0000269|PubMed:2394758"; MOD_RES 47; /note="4-hydroxyproline"; /evidence="ECO:0000269|PubMed:2394758, ECO:0000269|PubMed:3680255"; MOD_RES 50; /note="4-hydroxyproline"; /evidence="ECO:0000269|PubMed:2394758, ECO:0000269|PubMed:3680255"; MOD_RES 62; /note="4-hydroxyproline"; /evidence="ECO:0000269|PubMed:2394758, ECO:0000269|PubMed:3680255"; MOD_RES 65; /note="4-hydroxyproline"; /evidence="ECO:0000269|PubMed:2394758, ECO:0000269|PubMed:3680255"; MOD_RES 68; /note="4-hydroxyproline"; /evidence="ECO:0000269|PubMed:2394758, ECO:0000269|PubMed:3680255"; MOD_RES 71; /note="4-hydroxyproline"; /evidence="ECO:0000269|PubMed:2394758, ECO:0000269|PubMed:3680255"; MOD_RES 80; /note="Pyrrolidone carboxylic acid"; /evidence="ECO:0000269|PubMed:5529814"; MOD_RES 84; /note="Allysine"; /evidence="ECO:0000269|PubMed:5529814"; MOD_RES 102; /note="4-hydroxyproline"; /evidence="ECO:0000269|PubMed:3680255"; MOD_RES 108; /note="4-hydroxyproline"; /evidence="ECO:0000269|PubMed:3680255"; MOD_RES 177; /note="5-hydroxylysine; alternate"; /evidence="ECO:0000269|PubMed:4319110"; MOD_RES 420; /note="4-hydroxyproline"; /evidence="ECO:0000269|PubMed:4412529"; MOD_RES 441; /note="4-hydroxyproline"; /evidence="ECO:0000269|PubMed:4412529"; MOD_RES 444; /note="4-hydroxyproline"; /evidence="ECO:0000269|PubMed:4412529" |
| Post Translational Modification | PTM: Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains. {ECO:0000269|PubMed:4412529}. |
| Signal Peptide | SIGNAL 1..22; /evidence=ECO:0000250|UniProtKB:P02466 |
| Structure 3D | X-ray crystallography (4) |
| Cross Reference PDB | 5CTD; 5CTI; 5CVA; 6JEC; |
| Mapped Pubmed ID | 10479448; 10521801; 10551873; 10596943; 10627461; 10686426; 10809722; 10872800; 10887121; 10934207; 11084047; 11259413; 11310843; 11481033; 11518510; 11572855; 11577169; 11668615; 11700320; 11836364; 11986307; 12101112; 12160476; 12200454; 12211432; 12225811; 1237296; 12393755; 12424255; 12475640; 12496264; 12646579; 12702564; 12759229; 12813128; 12855811; 12879219; 12968017; 1323838; 1348714; 1400327; 14500733; 14555266; 14739420; 1484505; 15044469; 15075323; 15085313; 15149860; 15155468; 15211650; 15241796; 15257288; 15345715; 15365990; 15389632; 1544908; 15514164; 15516691; 15599596; 1567360; 15703183; 15741186; 1577494; 15788405; 15818662; 15837520; 15869882; 15917161; 15982862; 15983038; 16036621; 16091368; 16102041; 16192463; 16272566; 16278217; 16285730; 16293224; 16316921; 16463783; 16563355; 16564026; 16591531; 16702209; 16782899; 16806867; 16825197; 16849317; 16864092; 17072841; 17142024; 17146610; 171650; 17334644; 17407139; 17459242; 17485091; 17588949; 17620151; 17653508; 17875077; 17884818; 17903307; 18093617; 18209062; 18284430; 18298657; 18323784; 18434090; 18487197; 18570923; 18599485; 18644377; 18664619; 1874735; 18791848; 18818748; 19015742; 19035720; 19075007; 19180518; 19208385; 19282863; 19395477; 1939645; 19409513; 19424577; 19426706; 19491193; 19527514; 19559927; 19565505; 19578796; 19594296; 19679847; 19700402; 19705750; 19714363; 19790048; 19913121; 19929435; 19932771; 20087402; 20102701; 2010539; 20140262; 20452482; 20463013; 20466318; 20470363; 2059554; 20628086; 20673868; 20711500; 20721936; 20730098; 20736093; 20837772; 20961463; 21044367; 21252155; 21341209; 21405976; 21443102; 21530898; 21602843; 21665180; 21667357; 21690299; 21746880; 21789315; 21841309; 21874239; 21878990; 21967573; 22028813; 22049076; 22130917; 22131293; 22379029; 22674299; 22796342; 22815632; 23036172; 23079621; 23227268; 23546968; 23548243; 2364322; 23800505; 23918805; 24042342; 24058639; 24140640; 2430969; 24361166; 24434151; 24641356; 24668929; 24709079; 24804215; 24835590; 25107895; 25200162; 25290763; 25416956; 2543975; 25451260; 2551898; 25608812; 25692237; 25716998; 25858481; 25944380; 26065693; 26235824; 26260940; 26452701; 26471105; 26496610; 26564713; 26861712; 26910001; 26926600; 26927310; 27027429; 27090748; 27264419; 27454992; 27519266; 27655672; 27665867; 27691923; 27748872; 27894325; 27897211; 27997896; 28281531; 2834383; 28401451; 28424212; 2845110; 28498836; 28528406; 28612031; 28738217; 28810924; 28916840; 28930368; 28953610; 28981938; 29164999; 29543922; 29572562; 29594386; 29636545; 30172079; 30310058; 30358852; 3038863; 30583585; 30604926; 30683734; 30716784; 30825231; 30945869; 31159867; 31202624; 31371266; 3155520; 3159726; 3173483; 31794058; 31853946; 31876392; 32081708; 32091183; 32157794; 32166892; 32234057; 32335875; 32335877; 32482890; 32843132; 32989910; 33707149; 33737018; 33974636; 34290266; 34592197; 34727246; 3595596; 3872140; 3872795; 3905801; 3992061; 41816; 5246001; 5723342; 6129847; 6270089; 6313757; 641035; 6439184; 6809411; 710450; 7852349; 7890717; 8034572; 8144597; 8207089; 8440685; 8463259; 8576151; 8617742; 8631758; 8920930; 8943283; 8999957; 9028946; 9054364; 9092507; 9252349; 9295288; 9425086; 9470928; 9545296; 9560306; 9582318; 9651395; 9659899; 9659900; 9685393; |
| Motif | |
| Gene Encoded By | |
| Mass | 129,314 |
| Kinetics | |
| Metal Binding | METAL 1181; /note=Calcium; /evidence=ECO:0000250|UniProtKB:Q03692; METAL 1183; /note=Calcium; /evidence=ECO:0000250|UniProtKB:Q03692; METAL 1184; /note=Calcium; via carbonyl oxygen; /evidence=ECO:0000250|UniProtKB:Q03692; METAL 1186; /note=Calcium; via carbonyl oxygen; /evidence=ECO:0000250|UniProtKB:Q03692; METAL 1189; /note=Calcium; /evidence=ECO:0000250|UniProtKB:Q03692 |
| Rhea ID | |
| Cross Reference Brenda |