| IED ID | IndEnz0002017079 |
| Enzyme Type ID | protease017079 |
| Protein Name |
ATP-dependent Clp protease proteolytic subunit 1, mitochondrial EC 3.4.21.92 |
| Gene Name | clpp-1 CBG00853 |
| Organism | Caenorhabditis briggsae |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Nematoda (roundworms) Chromadorea Rhabditida Rhabditina Rhabditomorpha Rhabditoidea Rhabditidae Peloderinae Caenorhabditis Caenorhabditis briggsae |
| Enzyme Sequence | MLRRILTTSSVRNLTSSTQARVGIPFVIDNEGKGERTYDIYSRLLRDRIVCLMTPVDDFMASALIAQLLFLQSESSKKPIHMYINSPGGSVTAGLAIYDTMQMISAPVATWVIGQASSMGSLLLAAGEKGMRSALPNARIMVHQPSGGAQGTCSDIVIRAEEITRLKKRLNEIYVHHTGISYDEIERTLDRDRFMSAQEALKFGLVDKIEKHTGSMPTD |
| Enzyme Length | 219 |
| Uniprot Accession Number | A8WPG6 |
| Absorption | |
| Active Site | ACT_SITE 118; /note=Nucleophile; /evidence=ECO:0000250; ACT_SITE 143; /evidence=ECO:0000255 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec, and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs).; EC=3.4.21.92; Evidence={ECO:0000255}; |
| DNA Binding | |
| EC Number | 3.4.21.92 |
| Enzyme Function | FUNCTION: Clp cleaves peptides in various proteins in a process that requires ATP hydrolysis. Clp may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates (By similarity). {ECO:0000250|UniProtKB:Q27539}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Chain (1); Transit peptide (1) |
| Keywords | Hydrolase;Mitochondrion;Protease;Reference proteome;Serine protease;Transit peptide |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250|UniProtKB:Q27539}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 24,150 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |