| IED ID | IndEnz0002017301 |
| Enzyme Type ID | protease017301 |
| Protein Name |
Complement C2 EC 3.4.21.43 C3/C5 convertase Cleaved into: Complement C2b fragment; Complement C2a fragment |
| Gene Name | C2 |
| Organism | Mus musculus (Mouse) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse) |
| Enzyme Sequence | MAPLLALFYLLQLGPGLAALFCNQNVNITGGNFTLSHGWAPGSLLIYSCPLGRYPSPAWRKCQSNGQWLTPRSSSHHTLRSSRMVKAVCKPVRCLAPSSFENGIYFPRLVSYPVGSNVSFECEQDFTLRGSPVRYCRPNGLWDGETAVCDNGASHCPNPGISVGTARTGLNFDLGDKVRYRCSSSNMVLTGSAERECQSNGVWSGSEPICRQPYSYDFPEDVASALDTSLTNLLGATNPTQNLLTKSLGRKIIIQRSGHLNLYLLLDASQSVTEKDFDIFKKSAELMVERIFSFEVNVSVAIITFASQPKTIMSILSERSQDVTEVITSLDSASYKDHENATGTNTYEVLIRVYSMMQSQMDRLGMETSAWKEIRHTIILLTDGKSNMGDSPKKAVTRIRELLSIEQNRDDYLDIYAIGVGKLDVDWKELNELGSKKDGERHAFILQDAKALQQIFEHMLDVSKLTDTICGVGNMSANASDQERTPWQVTFKPKSKETCQGSLISDQWVLTAAHCFHDIQMEDHHLWRVNVGDPTSQHGKEFLVEDVIIAPGFNVHAKRKQGISEFYADDIALLKLSRKVKMSTHARPICLPCTVGANMALRRSPGSTCKDHETELLSQQKVPAHFVALNGNRLNINLRTGPEWTRCIQAVSQNKNIFPSLTNVSEVVTDQFLCSGMEEEDDNPCKGESGGAVFLGRRYRFFQVGLVSWGLFDPCHGSSNKNLRKKPPRGVLPRDFHISLFRLQPWLRQHLDGVLDFLPL |
| Enzyme Length | 760 |
| Uniprot Accession Number | P21180 |
| Absorption | |
| Active Site | ACT_SITE 514; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 570; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 689; /note=Charge relay system; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Selective cleavage of Arg-|-Ser bond in complement component C3 alpha-chain to form C3a and C3b, and Arg-|-Xaa bond in complement component C5 alpha-chain to form C5a and C5b.; EC=3.4.21.43; |
| DNA Binding | |
| EC Number | 3.4.21.43 |
| Enzyme Function | FUNCTION: Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Alternative sequence (1); Chain (3); Disulfide bond (8); Domain (5); Glycosylation (8); Metal binding (3); Motif (1); Sequence conflict (12); Signal peptide (1) |
| Keywords | Alternative splicing;Complement pathway;Disulfide bond;Glycoprotein;Hydrolase;Immunity;Innate immunity;Metal-binding;Protease;Reference proteome;Repeat;Secreted;Serine protease;Signal;Sushi |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..18 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 10229798; 10686478; 10871872; 11261934; 11359841; 11739537; 1394787; 16002707; 18672286; 19000842; 1970336; 20065024; 20657840; 21267068; 21386911; 21502587; 22689574; 24006456; 2883115; 3034587; 3902621; 6088393; 6190740; 6735447; 6770000; 7641699; 8133044; 8138038; 9430715; |
| Motif | MOTIF 267..271; /note=MIDAS-like motif; /evidence=ECO:0000250 |
| Gene Encoded By | |
| Mass | 84,741 |
| Kinetics | |
| Metal Binding | METAL 269; /note=Divalent metal cation; /evidence=ECO:0000250; METAL 271; /note=Divalent metal cation; /evidence=ECO:0000250; METAL 344; /note=Divalent metal cation; /evidence=ECO:0000250 |
| Rhea ID | |
| Cross Reference Brenda |