IED Industry Enzyme Database

Detail Information for IndEnz0002017388
IED ID IndEnz0002017388
Enzyme Type ID protease017388
Protein Name Collagen alpha-1
III
chain
Gene Name COL3A1
Organism Homo sapiens (Human)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human)
Enzyme Sequence MMSFVQKGSWLLLALLHPTIILAQQEAVEGGCSHLGQSYADRDVWKPEPCQICVCDSGSVLCDDIICDDQELDCPNPEIPFGECCAVCPQPPTAPTRPPNGQGPQGPKGDPGPPGIPGRNGDPGIPGQPGSPGSPGPPGICESCPTGPQNYSPQYDSYDVKSGVAVGGLAGYPGPAGPPGPPGPPGTSGHPGSPGSPGYQGPPGEPGQAGPSGPPGPPGAIGPSGPAGKDGESGRPGRPGERGLPGPPGIKGPAGIPGFPGMKGHRGFDGRNGEKGETGAPGLKGENGLPGENGAPGPMGPRGAPGERGRPGLPGAAGARGNDGARGSDGQPGPPGPPGTAGFPGSPGAKGEVGPAGSPGSNGAPGQRGEPGPQGHAGAQGPPGPPGINGSPGGKGEMGPAGIPGAPGLMGARGPPGPAGANGAPGLRGGAGEPGKNGAKGEPGPRGERGEAGIPGVPGAKGEDGKDGSPGEPGANGLPGAAGERGAPGFRGPAGPNGIPGEKGPAGERGAPGPAGPRGAAGEPGRDGVPGGPGMRGMPGSPGGPGSDGKPGPPGSQGESGRPGPPGPSGPRGQPGVMGFPGPKGNDGAPGKNGERGGPGGPGPQGPPGKNGETGPQGPPGPTGPGGDKGDTGPPGPQGLQGLPGTGGPPGENGKPGEPGPKGDAGAPGAPGGKGDAGAPGERGPPGLAGAPGLRGGAGPPGPEGGKGAAGPPGPPGAAGTPGLQGMPGERGGLGSPGPKGDKGEPGGPGADGVPGKDGPRGPTGPIGPPGPAGQPGDKGEGGAPGLPGIAGPRGSPGERGETGPPGPAGFPGAPGQNGEPGGKGERGAPGEKGEGGPPGVAGPPGGSGPAGPPGPQGVKGERGSPGGPGAAGFPGARGLPGPPGSNGNPGPPGPSGSPGKDGPPGPAGNTGAPGSPGVSGPKGDAGQPGEKGSPGAQGPPGAPGPLGIAGITGARGLAGPPGMPGPRGSPGPQGVKGESGKPGANGLSGERGPPGPQGLPGLAGTAGEPGRDGNPGSDGLPGRDGSPGGKGDRGENGSPGAPGAPGHPGPPGPVGPAGKSGDRGESGPAGPAGAPGPAGSRGAPGPQGPRGDKGETGERGAAGIKGHRGFPGNPGAPGSPGPAGQQGAIGSPGPAGPRGPVGPSGPPGKDGTSGHPGPIGPPGPRGNRGERGSEGSPGHPGQPGPPGPPGAPGPCCGGVGAAAIAGIGGEKAGGFAPYYGDEPMDFKINTDEIMTSLKSVNGQIESLISPDGSRKNPARNCRDLKFCHPELKSGEYWVDPNQGCKLDAIKVFCNMETGETCISANPLNVPRKHWWTDSSAEKKHVWFGESMDGGFQFSYGNPELPEDVLDVHLAFLRLLSSRASQNITYHCKNSIAYMDQASGNVKKALKLMGSNEGEFKAEGNSKFTYTVLEDGCTKHTGEWSKTVFEYRTRKAVRLPIVDIAPYDIGGPDQEFGVDVGPVCFL
Enzyme Length 1466
Uniprot Accession Number P02461
Absorption
Active Site
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number
Enzyme Function FUNCTION: Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of ADGRG1 in the developing brain and binding to ADGRG1 inhibits neuronal migration and activates the RhoA pathway by coupling ADGRG1 to GNA13 and possibly GNA12.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Alternative sequence (1); Beta strand (19); Chain (1); Compositional bias (7); Disulfide bond (7); Domain (2); Glycosylation (1); Helix (7); Metal binding (5); Modified residue (150); Natural variant (119); Propeptide (2); Region (4); Sequence conflict (35); Signal peptide (1); Turn (2)
Keywords 3D-structure;Alternative splicing;Aortic aneurysm;Calcium;Collagen;Direct protein sequencing;Disease variant;Disulfide bond;Ehlers-Danlos syndrome;Extracellular matrix;Glycoprotein;Hydroxylation;Metal-binding;Reference proteome;Repeat;Secreted;Signal
Interact With O01949; P09486; P63010-2; Q53G59
Induction
Subcellular Location SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000255|PROSITE-ProRule:PRU00793}.
Modified Residue MOD_RES 173; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:557335; MOD_RES 179; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:557335; MOD_RES 182; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:557335; MOD_RES 185; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:557335; MOD_RES 191; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:557335; MOD_RES 194; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:557335; MOD_RES 197; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:557335; MOD_RES 203; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:557335; MOD_RES 206; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:557335; MOD_RES 215; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:557335; MOD_RES 218; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:557335; MOD_RES 236; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:557335; MOD_RES 239; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:557335; MOD_RES 245; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:557335; MOD_RES 248; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:557335; MOD_RES 257; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:557335; MOD_RES 260; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:557335; MOD_RES 263; /note=5-hydroxylysine; alternate; /evidence=ECO:0000269|PubMed:557335; MOD_RES 281; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:557335; MOD_RES 284; /note=5-hydroxylysine; /evidence=ECO:0000269|PubMed:557335; MOD_RES 290; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:557335; MOD_RES 296; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:557335; MOD_RES 305; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:557335; MOD_RES 311; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:557335; MOD_RES 314; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:557335; MOD_RES 332; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:557335; MOD_RES 335; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:557335; MOD_RES 338; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:557335; MOD_RES 344; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:557335; MOD_RES 347; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:557335; MOD_RES 359; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:557335; MOD_RES 365; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:557335; MOD_RES 371; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:557335; MOD_RES 383; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:557335; MOD_RES 386; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:557335; MOD_RES 392; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:557335; MOD_RES 404; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:687591; MOD_RES 407; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:687591; MOD_RES 416; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:687591; MOD_RES 425; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:687591; MOD_RES 434; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:687591; MOD_RES 443; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:687591; MOD_RES 455; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:687591; MOD_RES 458; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:687591; MOD_RES 470; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:687591; MOD_RES 473; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:687591; MOD_RES 479; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:687591; MOD_RES 488; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:687591; MOD_RES 500; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:687591; MOD_RES 512; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:687591; MOD_RES 524; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:687591; MOD_RES 530; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:687591; MOD_RES 533; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:687591; MOD_RES 539; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:687591; MOD_RES 542; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:687591; MOD_RES 545; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:687591; MOD_RES 551; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:687591; MOD_RES 554; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:687591; MOD_RES 563; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:687591; MOD_RES 566; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:687591; MOD_RES 575; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:687591; MOD_RES 581; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:687591; MOD_RES 590; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:687591; MOD_RES 599; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:687591; MOD_RES 602; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:687591; MOD_RES 608; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:687591; MOD_RES 620; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:687591; MOD_RES 635; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:687591; MOD_RES 644; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:687591; MOD_RES 650; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:687591; MOD_RES 656; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:687591; MOD_RES 659; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:687591; MOD_RES 661; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:687591; MOD_RES 668; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:687591; MOD_RES 671; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:687591; MOD_RES 680; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:687591; MOD_RES 686; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:687591; MOD_RES 692; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:687591; MOD_RES 701; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:687591; MOD_RES 703; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:687591; MOD_RES 713; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:687591; MOD_RES 716; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:687591; MOD_RES 722; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:687591; MOD_RES 728; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:6246925; MOD_RES 737; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:6246925; MOD_RES 746; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:6246925; MOD_RES 749; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:6246925; MOD_RES 755; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:6246925; MOD_RES 770; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:6246925; MOD_RES 776; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:6246925; MOD_RES 785; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:6246925; MOD_RES 788; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:6246925; MOD_RES 797; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:6246925; MOD_RES 806; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:6246925; MOD_RES 812; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:6246925; MOD_RES 815; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:6246925; MOD_RES 821; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:6246925; MOD_RES 830; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:6246925; MOD_RES 839; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:6246925; MOD_RES 845; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:6246925; MOD_RES 854; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:6246925; MOD_RES 860; /note=5-hydroxylysine; /evidence=ECO:0000269|PubMed:6246925; MOD_RES 866; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:6246925; MOD_RES 869; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:6246925; MOD_RES 875; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:6246925; MOD_RES 881; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:6246925; MOD_RES 884; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:6246925; MOD_RES 890; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:6246925; MOD_RES 892; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:6246925; MOD_RES 899; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:6246925; MOD_RES 905; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:6246925; MOD_RES 914; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:6246925; MOD_RES 917; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:6246925; MOD_RES 929; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:6246925; MOD_RES 935; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:6246925; MOD_RES 941; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:6246925; MOD_RES 944; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:6246925; MOD_RES 962; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:6246925; MOD_RES 965; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:7016180; MOD_RES 971; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:7016180; MOD_RES 977; /note=5-hydroxylysine; /evidence=ECO:0000269|PubMed:7016180; MOD_RES 983; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:7016180; MOD_RES 995; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:7016180; MOD_RES 1001; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:7016180; MOD_RES 1010; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:7016180; MOD_RES 1016; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:7016180; MOD_RES 1022; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:7016180; MOD_RES 1028; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:7016180; MOD_RES 1040; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:7016180; MOD_RES 1043; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:7016180; MOD_RES 1046; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:7016180; MOD_RES 1049; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:7016180; MOD_RES 1052; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:7016180; MOD_RES 1076; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:7016180; MOD_RES 1085; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:7016180; MOD_RES 1106; /note=5-hydroxylysine; /evidence=ECO:0000269|PubMed:7016180; MOD_RES 1112; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:7016180; MOD_RES 1115; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:7016180; MOD_RES 1118; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:7016180; MOD_RES 1121; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:7016180; MOD_RES 1133; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:7016180; MOD_RES 1148; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:7016180; MOD_RES 1157; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:7016180; MOD_RES 1163; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:7016180; MOD_RES 1178; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:7016180; MOD_RES 1181; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:7016180; MOD_RES 1184; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:7016180; MOD_RES 1187; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:7016180; MOD_RES 1190; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:7016180; MOD_RES 1193; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:7016180
Post Translational Modification PTM: Proline residues at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains. {ECO:0000269|PubMed:557335, ECO:0000269|PubMed:7016180}.; PTM: O-linked glycan consists of a Glc-Gal disaccharide bound to the oxygen atom of a post-translationally added hydroxyl group.
Signal Peptide SIGNAL 1..23
Structure 3D X-ray crystallography (8)
Cross Reference PDB 2V53; 3DMW; 4AE2; 4AEJ; 4AK3; 4GYX; 6FZV; 6FZW;
Mapped Pubmed ID 10479448; 10508235; 10521801; 10551873; 10596943; 10686426; 10809722; 10934207; 11310843; 11572855; 11577169; 11698112; 12140670; 12149201; 12475640; 12646579; 1311092; 1323838; 14500733; 15044469; 15155468; 15193836; 15257288; 15383545; 1544908; 1577494; 15837520; 16591531; 16754661; 16782899; 16806867; 16825197; 171650; 17635036; 18209062; 18487197; 19011090; 19075007; 19542224; 1998337; 20015075; 2002056; 20470363; 2059554; 20711500; 20730098; 21690299; 21789315; 21841309; 21878990; 21967573; 23027749; 23132862; 2430969; 24835590; 2543975; 2548603; 2551898; 25716998; 2574578; 2809592; 2834383; 2845110; 30078642; 3038863; 3159726; 3173483; 3872795; 3905801; 6270089; 6439184; 6809411; 710450; 8118028; 8144597; 8344274; 8440685; 8463259; 8576151; 8900172; 8920930; 8999957; 9054364; 9092507; 9252349; 9334164; 9501084; 9545296; 9560306; 9582318; 9651395; 9659899; 9659900;
Motif
Gene Encoded By
Mass 138,564
Kinetics
Metal Binding METAL 1280; /note=Calcium; METAL 1282; /note=Calcium; METAL 1283; /note=Calcium; via carbonyl oxygen; METAL 1285; /note=Calcium; via carbonyl oxygen; METAL 1288; /note=Calcium
Rhea ID
Cross Reference Brenda