Detail Information for IndEnz0002017410
IED ID IndEnz0002017410
Enzyme Type ID protease017410
Protein Name Collagen alpha-1
III
chain
Gene Name Col3a1
Organism Rattus norvegicus (Rat)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Rattus Rattus norvegicus (Rat)
Enzyme Sequence MMSFVQCGTWFLLTLLHPSLILAQQSNVDELGCNYLGQSYESRDVWKPEPCQICVCDSGSVLCDDIMCDDEPLDCPNPEIPFGECCAICPQPSTPAPVIPDGNRPQGPKGDPGPPGIPGRNGDPGLPGQPGLPGPPGSPGICESCPTGGQNYSPQFDSYDVKSGVGGMGGYPGPAGPPGPPGPPGSSGHPGSPGSPGYQGPPGEPGQAGPAGPPGPPGAIGPSGPAGKDGESGRPGRPGERGLPGPPGIKGPAGIPGFPGMKGHRGFDGRNGEKGETGAPGLKGENGLPGDNGAPGPMGPRGAPGERGRPGLPGAAGARGNDGARGSDGQPGPPGPPGTAGFPGSPGAKGEVGPAGSPGSNGSPGQRGEPGPQGHAGAQGPPGPPGNNGSPGGKGEMGPAGIPGAPGLLGARGPPGPAGANGAPGQRGPSGEPGKNGAKGEPGARGERGEAGSPGIPGPKGEDGKDGSPGEPGANGVPGNPGERGAPGFRGPAGPNGAPGEKGPAGERGGPGPAGPRGVAGEPGRDGTPGGPGIRGMPGSPGGPGNDGKPGPPGSQGESGRPGPPGPSGPRGQPGVMGFPGPKGNDGAPGKNGERGGPGGPGLPGPAGKNGETGPQGPPGPTGAPGDKGDAGPPGPQGLQGIPGTSGPPGENGKPGEPGPKGEAGAPGVPGGKGDSGAPGERGPPGTAGTPGLRGGAGPPGPEGGKGPAGPPGPPGTSGPPGLQGMPGERGGPGSPGPKGEKGEPGGAGADGVPGKDGPRGPAGPIGPPGPAGQPGDKGEGGAPGLPGIAGPRGGPGERGEHGPPGPAGFPGAPGQNGEPGAKGERGAPGEKGEGGPPGAAGPPGGSGPAGPPGPQGVKGERGSPGGPGAAGFPGGRGLPGPPGNNGNPGPPGPSGAPGKDGPPGPAGNSGSPGNPGVAGPKGDAGQPGEKGPPGAQGPPGSPGPLGIAGLTGARGLAGPPGMPGPRGSPGPQGIKGESGKPGASGHNGERGPPGPQGLPGQPGTAGEPGRDGNPGSDGQPGRDGSPGGKGDRGENGSPGAPGAPGHPGPPGPVGPSGKNGDRGETGPAGPSGAPGPAGARGAPGPQGPRGDKGETGERGSNGIKGHRGFPGNPGPPGSPGAAGHQGAVGSPGPAGPRGPVGPHGPPGKDGSSGHPGPIGPPGPRGNRGERGSEGSPGHPGQPGPPGPPGAPGPCCGGGAAIAGVGGEKSGGFSPYYGDDPMDFKINTEEIMSSLKSVNGQIESLISPDGSRKNPARNCRDLKFCHPELKSGEYWVDPNQGCKMDAIKVFCNMETGETCINASPMTVPRKHWWTDAGAEKKHVWFGESMNGGFQFSYGNPDLPEDVLDVQLAFLRLLSSRASQNITYHCKNSIAYMDQANGNVKKSLKLMGSNEGEFKAEGNSKFTYTVLEDGCTKHTGEWSKTVFEYQTRKAMRLPIIDIAPYDIGGPDQEFGVDIGPVCFL
Enzyme Length 1463
Uniprot Accession Number P13941
Absorption
Active Site
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number
Enzyme Function FUNCTION: Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of ADGRG1 in the developing brain and binding to ADGRG1 inhibits neuronal migration and activates the RhoA pathway by coupling ADGRG1 to GNA13 and possibly GNA12 (By similarity). {ECO:0000250}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Chain (1); Compositional bias (8); Disulfide bond (7); Domain (2); Glycosylation (1); Metal binding (5); Modified residue (6); Propeptide (2); Region (3); Sequence conflict (2); Signal peptide (1)
Keywords Calcium;Collagen;Disulfide bond;Extracellular matrix;Glycoprotein;Hydroxylation;Metal-binding;Reference proteome;Repeat;Secreted;Signal
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000255|PROSITE-ProRule:PRU00793}.
Modified Residue MOD_RES 262; /note=5-hydroxylysine; alternate; /evidence=ECO:0000250; MOD_RES 283; /note=5-hydroxylysine; /evidence=ECO:0000250; MOD_RES 859; /note=5-hydroxylysine; /evidence=ECO:0000250; MOD_RES 976; /note=5-hydroxylysine; /evidence=ECO:0000250; MOD_RES 1093; /note=5-hydroxylysine; /evidence=ECO:0000250; MOD_RES 1105; /note=5-hydroxylysine; /evidence=ECO:0000250
Post Translational Modification PTM: O-glycosylated. {ECO:0000250}.; PTM: Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
Signal Peptide SIGNAL 1..23; /evidence=ECO:0000250
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID 10373016; 17623297; 20610530; 20836762; 20839322; 23313213; 25636075; 26097527; 26578432;
Motif
Gene Encoded By
Mass 138,936
Kinetics
Metal Binding METAL 1277; /note=Calcium; /evidence=ECO:0000250; METAL 1279; /note=Calcium; /evidence=ECO:0000250; METAL 1280; /note=Calcium; via carbonyl oxygen; /evidence=ECO:0000250; METAL 1282; /note=Calcium; via carbonyl oxygen; /evidence=ECO:0000250; METAL 1285; /note=Calcium; /evidence=ECO:0000250
Rhea ID
Cross Reference Brenda