| IED ID |
IndEnz0002017746 |
| Enzyme Type ID |
protease017746 |
| Protein Name |
ATP-dependent Clp protease ATP-binding subunit ClpX
|
| Gene Name |
clpX STM0449 |
| Organism |
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) |
| Taxonomic Lineage |
cellular organisms
Bacteria
Proteobacteria
Gammaproteobacteria
Enterobacterales
Enterobacteriaceae
Salmonella
Salmonella enterica (Salmonella choleraesuis)
Salmonella enterica I
Salmonella typhimurium
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
|
| Enzyme Sequence |
MTDKRKDGSGKLLYCSFCGKSQHEVRKLIAGPSVYICDECVDLCNDIIREEIKEVAPHRERSALPTPHEIRTHLDDYVIGQEQAKKVLAVAVYNHYKRLRNGDTSNGVELGKSNILLIGPTGSGKTLLAETLARLLDVPFTMADATTLTEAGYVGEDVENIIQKLLQKCDYDVQKAQRGIVYIDEIDKISRKSDNPSITRDVSGEGVQQALLKLIEGTVAAVPPQGGRKHPQQEFLQVDTSKILFICGGAFAGLDKVIANRVETGSGIGFGATVKAKSDKASEGELLSQVEPEDLIKFGLIPEFIGRLPVVATLNELSEEALIQILKEPKNALTKQYQALFNLEGVDLEFRDEALDAIARKAMARKTGARGLRSIVEAALLDTMYDLPSMEDVEKVVIDESVIAGQSKPLLIYGKPEAQASGE |
| Enzyme Length |
423 |
| Uniprot Accession Number |
Q8ZRC0 |
| Absorption |
|
| Active Site |
|
| Activity Regulation |
|
| Binding Site |
|
| Calcium Binding |
|
| catalytic Activity |
|
| DNA Binding |
|
| EC Number |
|
| Enzyme Function |
FUNCTION: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. {ECO:0000255|HAMAP-Rule:MF_00175}. |
| Temperature Dependency |
|
| PH Dependency |
|
| Pathway |
|
| nucleotide Binding |
NP_BIND 120..127; /note=ATP; /evidence=ECO:0000255|HAMAP-Rule:MF_00175 |
| Features |
Chain (1); Domain (1); Metal binding (4); Nucleotide binding (1) |
| Keywords |
ATP-binding;Chaperone;Metal-binding;Nucleotide-binding;Reference proteome;Zinc |
| Interact With |
|
| Induction |
|
| Subcellular Location |
|
| Modified Residue |
|
| Post Translational Modification |
|
| Signal Peptide |
|
| Structure 3D |
|
| Cross Reference PDB |
- |
| Mapped Pubmed ID |
18245288;
22380597;
23385142;
25278020;
|
| Motif |
|
| Gene Encoded By |
|
| Mass |
46,176 |
| Kinetics |
|
| Metal Binding |
METAL 15; /note=Zinc; /evidence=ECO:0000255|PROSITE-ProRule:PRU01250; METAL 18; /note=Zinc; /evidence=ECO:0000255|PROSITE-ProRule:PRU01250; METAL 37; /note=Zinc; /evidence=ECO:0000255|PROSITE-ProRule:PRU01250; METAL 40; /note=Zinc; /evidence=ECO:0000255|PROSITE-ProRule:PRU01250 |
| Rhea ID |
|
| Cross Reference Brenda |
3.4.21.92; |