| IED ID | IndEnz0002017757 |
| Enzyme Type ID | protease017757 |
| Protein Name |
CLIP domain-containing serine protease 14D AgSp14D1 EC 3.4.21.- |
| Gene Name | CLIPB4 SP14D1 AGAP003250 |
| Organism | Anopheles gambiae (African malaria mosquito) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Panarthropoda Arthropoda Mandibulata Pancrustacea Hexapoda Insecta Dicondylia Pterygota (winged insects) Neoptera Endopterygota Diptera Nematocera Culicomorpha Culicoidea Culicidae (mosquitos) Anophelinae Anopheles Cellia Pyretophorus gambiae species complex Anopheles gambiae (African malaria mosquito) |
| Enzyme Sequence | MIGNRVINLLIVATLALAGQTVLALELGQDCVNPVGEAGKCVLFRECQPLVDIYNKPVNTPDDTQFLTESRCGLYERKTLVCCAGVRSKGKTSLPESPNCGVQLTDRVIGGQPTKIDEFPWTALIEYEKPNGRFGFHCGGSVINERYILTAAHCITSIPRGWKVHRVRLGEWDLSSTTDQEDDFYADAPIDLDIEKIIVHPGYNLQDKSHHNDIALIRFNREINYSSTISAICLPLSNSLRNRKHAGLSSYAAGWGKTETASASQKKLKVELTVVDVKDCSPAYQRNGISLDSTQMCAGGIRGKDTCSGDSGGPLMRQMSGSWYLIGVVSFGPQKCGAPGVPGVYTNVAEYVDWIKDNIY |
| Enzyme Length | 360 |
| Uniprot Accession Number | Q7PEV7 |
| Absorption | |
| Active Site | ACT_SITE 153; /note=Charge relay system; /evidence=ECO:0000255|PROSITE-ProRule:PRU00274; ACT_SITE 213; /note=Charge relay system; /evidence=ECO:0000255|PROSITE-ProRule:PRU00274; ACT_SITE 311; /note=Charge relay system; /evidence=ECO:0000255|PROSITE-ProRule:PRU00274 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.21.- |
| Enzyme Function | FUNCTION: Probable serine protease which may play a role in immune responses. {ECO:0000305|PubMed:10469250, ECO:0000305|PubMed:10646969}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (1); Disulfide bond (6); Domain (2); Glycosylation (1); Sequence conflict (10); Signal peptide (1) |
| Keywords | Disulfide bond;Glycoprotein;Hydrolase;Protease;Reference proteome;Secreted;Serine protease;Signal |
| Interact With | |
| Induction | INDUCTION: Induced following a blood meal (PubMed:10469250). Induced in response to bacterial infection (PubMed:10469250, PubMed:10646969). Induced in response to P.berghei infection (PubMed:10646969). {ECO:0000269|PubMed:10469250, ECO:0000269|PubMed:10646969}. |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted {ECO:0000305}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..24; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 39,382 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |