| IED ID | IndEnz0002018218 |
| Enzyme Type ID | protease018218 |
| Protein Name |
Cartilage intermediate layer protein 2 Cleaved into: Cartilage intermediate layer protein 2 C1; Cartilage intermediate layer protein 2 C2 |
| Gene Name | Cilp2 |
| Organism | Mus musculus (Mouse) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse) |
| Enzyme Sequence | MASPLPLLYLCLAALHLAGARDATPTEEHTSTARGLQGRPPDTGQPSPALEDWEEASEWTSWFNVDHPGGDGDFESLAAIRFYYGPARVCPRPLALEARTTDWALPAAMGERVHANPERGFWCLNREQPRGRRCSNYHVRFRCPLEAAWGAWGAWGLCSKSCGLGRRLRRRSCQSSSGDTCPGSPQEAQKCVRSRCPGCSSDTCGCPNHILLGSVVTPSGRPLSGARVSLRTRPGTIATSGTHGTFQVPGVCAGSKASVSAQMNGFSAGTAQAHANSSNTATVTIILEELGKPYLVKHPESRVREAGQNVTFCCKASGTPMPKKYSWFHNGTLLDRRQQGSGPHLELQGLHQAQAGEYHCKAWNEAGTVRSRAALLTILAPGQQACDPRPQEHLIKLPDDCGQPGGGPTYLDVGLCADTRCPGPVGSGPRCGDAGSRCCSVLRLESRDIRCSGYVLPVKVVAECGCRKCLPRRGLVRGRVVAADSGEPLRFARILLGRAPIGFTSYQGDFTIEVPPATERLVVTFVDPSGDFVDSVRVLPFDPRGAGVYHEIRALRKAAAVLLDAERGGEIPLGSTEEAPALGELVLPPGTFHHPDGRPYTGPVEARVTFVDPRDLASASAASSDLRFLDSAGELAPLRTYGMFAVDLRAPGSTEQLHVARADVHVDADHVRMPGHAEALALWSLDPETGLWEEEGSEQGSGGFRRETAAARVRREERAFLVGALTMRERRLFNLDVPERRRCFVKVRAYGTDRFAPAEQVQGVVVTLLNLEPAPGFTANPRAWGRFDSAVTGPNGACVPAFCDAEKPDAYTAFVTAALGGEELEAAPSRPRATAAVVGVAQPYLERLGYQRTDHDDPALKRTGFRLNLARPRAGHESEAHGPVYPWRRLRDCEDAPVTDSHFRFSRVEADKYEYDVVPFHEGAPASWTGDLLAWWPNPQEFRACFLKVRLQGPQEYMVRSHNAGGTHEATRGRLYGLRDTRSVRHPERPGASAACVEFKCGGMLFDQRQVDRTLVTVTPQGSCRRVAVNTLLQDYLARHPPLAAADDPAAFAMLAPLDALGHNYGVYTVTDQSPRLAKEIAIGRCFDGSSDGFSREMKADAGTAVTFQCREPPARPSLFQRLLENPSSALGDIRREMGQATRYSRVNQTQAGDTGPFGPGQ |
| Enzyme Length | 1162 |
| Uniprot Accession Number | D3Z7H8 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: May play a role in cartilage scaffolding. {ECO:0000250|UniProtKB:O75339}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (3); Disulfide bond (4); Domain (2); Glycosylation (1); Region (1); Signal peptide (1) |
| Keywords | Cleavage on pair of basic residues;Disulfide bond;Extracellular matrix;Glycoprotein;Immunoglobulin domain;Reference proteome;Secreted;Signal |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:Q8IUL8}. |
| Modified Residue | |
| Post Translational Modification | PTM: May be cleaved into 2 chains possibly by a furin-like protease upon or preceding secretion. {ECO:0000305|PubMed:21880736}.; PTM: N-glycosylated. {ECO:0000269|PubMed:21880736}. |
| Signal Peptide | SIGNAL 1..20; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 125,934 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |