IED ID | IndEnz0002018335 |
Enzyme Type ID | protease018335 |
Protein Name |
Transcriptional regulator ClgR ClpR-like regulator clp gene regulator |
Gene Name | clgR Rv2745c |
Organism | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
Taxonomic Lineage | cellular organisms Bacteria Terrabacteria group Actinobacteria Actinomycetia (high G+C Gram-positive bacteria) Corynebacteriales Mycobacteriaceae Mycobacterium Mycobacterium tuberculosis complex Mycobacterium tuberculosis Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
Enzyme Sequence | MAALVREVVGDVLRGARMSQGRTLREVSDSARVSLGYLSEIERGRKEPSSELLSAICTALQLPLSVVLIDAGERMARQERLARATPAGRATGATIDASTKVVIAPVVSLAVA |
Enzyme Length | 112 |
Uniprot Accession Number | P9WMH7 |
Absorption | |
Active Site | |
Activity Regulation | |
Binding Site | |
Calcium Binding | |
catalytic Activity | |
DNA Binding | DNA_BIND 24..43; /note=H-T-H motif; /evidence=ECO:0000255|PROSITE-ProRule:PRU00257 |
EC Number | |
Enzyme Function | FUNCTION: Key stress-response regulator that plays an important role in multiple regulatory networks in response to different stress conditions (PubMed:20688819, PubMed:25899163). Involved in preservation of envelope integrity and tolerance to surface stress (PubMed:25899163). Essential for macrophage infection and facilitates intracellular growth of M.tuberculosis (PubMed:25899163, PubMed:20688819). Controls the expression of several protease and chaperone systems, including clpP1, clpP2, clpC1, ptrB, Rv1043c, acr2, clpB, Rv3269 and the clgR-pspA-rv2743c-rv2742c region (PubMed:20688819, PubMed:25899163, PubMed:23560081). Also plays an essential role in RecA/LexA-independent DNA repair mechanism by inducing expression of DNA repair genes in response to DNA damage (PubMed:21771781). {ECO:0000269|PubMed:20688819, ECO:0000269|PubMed:21771781, ECO:0000269|PubMed:23560081, ECO:0000269|PubMed:25899163}. |
Temperature Dependency | |
PH Dependency | |
Pathway | |
nucleotide Binding | |
Features | Chain (1); DNA binding (1); Domain (1) |
Keywords | DNA-binding;Reference proteome;Stress response;Transcription;Transcription regulation |
Interact With | |
Induction | INDUCTION: Expression requires SigE (PubMed:11489128, PubMed:25899163). Induced by carbonyl cyanide m-chlorophenyl hydrazone (CCCP) (PubMed:25899163). Induced in response to thioridazine (THZ) (PubMed:20386700). {ECO:0000269|PubMed:11489128, ECO:0000269|PubMed:20386700, ECO:0000269|PubMed:25899163}. |
Subcellular Location | |
Modified Residue | |
Post Translational Modification | |
Signal Peptide | |
Structure 3D | |
Cross Reference PDB | - |
Mapped Pubmed ID | - |
Motif | |
Gene Encoded By | |
Mass | 11,786 |
Kinetics | |
Metal Binding | |
Rhea ID | |
Cross Reference Brenda |