| IED ID |
IndEnz0002018367 |
| Enzyme Type ID |
protease018367 |
| Protein Name |
Clathrin heavy chain 1
|
| Gene Name |
Cltc |
| Organism |
Rattus norvegicus (Rat) |
| Taxonomic Lineage |
cellular organisms
Eukaryota
Opisthokonta
Metazoa
Eumetazoa
Bilateria
Deuterostomia
Chordata
Craniata
Vertebrata
Gnathostomata (jawed vertebrates)
Teleostomi
Euteleostomi
Sarcopterygii
Dipnotetrapodomorpha
Tetrapoda
Amniota
Mammalia
Theria
Eutheria
Boreoeutheria
Euarchontoglires
Glires (Rodents and rabbits)
Rodentia
Myomorpha (mice and others)
Muroidea
Muridae
Murinae
Rattus
Rattus norvegicus (Rat)
|
| Enzyme Sequence |
MAQILPIRFQEHLQLQNLGINPANIGFSTLTMESDKFICIREKVGEQAQVVIIDMNDPSNPIRRPISADSAIMNPASKVIALKAGKTLQIFNIEMKSKMKAHTMTDDVTFWKWISLNTVALVTDNAVYHWSMEGESQPVKMFDRHSSLAGCQIINYRTDAKQKWLLLTGISAQQNRVVGAMQLYSVDRKVSQPIEGHAASFAQFKMEGNAEESTLFCFAVRGQAGGKLHIIEVGTPPTGNQPFPKKAVDVFFPPEAQNDFPVAMQISEKHDVVFLITKYGYIHLYDLETGTCIYMNRISGETIFVTAPHEATAGIIGVNRKGQVLSVCVEEENIIPYITNVLQNPDLALRMAVRNNLAGAEELFARKFNALFAQGNYSEAAKVAANAPKGILRTPDTIRRFQSVPAQPGQTSPLLQYFGILLDQGQLNKYESLELCRPVLQQGRKQLLEKWLKEDKLECSEELGDLVKSVDPTLALSVYLRANVPNKVIQCFAETGQVQKIVLYAKKVGYTPDWIFLLRNVMRISPDQGQQFAQMLVQDEEPLADITQIVDVFMEYNLIQQCTAFLLDALKNNRPSEGPLQTRLLEMNLMHAPQVADAILGNQMFTHYDRAHIAQLCEKAGLLQRALEHFTDLYDIKRAVVHTHLLNPEWLVNYFGSLSVEDSLECLRAMLSANIRQNLQIWVQVASKYHEQLSTQSLIELFESFKSFEGLFYFLGSIVNFSQDPDVHFKYIQAACKTGQIKEVERICRESNCYDPERVKNFLKEAKLTDQLPLIIVCDRFDFVHDLVLYLYRNSLQKYIEIYVQKVNPSRLPVVIGGLLDVDCSEDVIKNLILVVRGQFSTDELVAEVEKRNRLKLLLPWLEARIHEGCEEPATHNALAKIYIDSNNNPERFLRENPYYDSRVVGKYCEKRDPHLACVAYERGQCDLELINVCNENSLFKSLSRYLVRRKDPELWGSVLLESNPYRRPLIDQVVQTALSETQDPEEVSVTVKAFMTADLPNELIELLEKIVLDNSVFSEHRNLQNLLILTAIKADRTRVMEYINRLDNYDAPDIANIAISNELFEEAFAIFRKFDVNTSAVQVLIEHIGNLDRAYEFAERCNEPAVWSQLAKAQLQKGMVKEAIDSYIKADDPSSYMEVVQAANTSGNWEELVKYLQMARKKARESYVETELIFALAKTNRLAELEEFINGPNNAHIQQVGDRCYDEKMYDAAKLLYNNVSNFGRLASTLVHLGEYQAAVDGARKANSTRTWKEVCFACVDGKEFRLAQMCGLHIVVHADELEELINYYQDRGYFEELITMLEAALGLERAHMGMFTELAILYSKFKPQKMREHLELFWSRVNIPKVLRAAEQAHLWAELVFLYDKYEEYDNAIITMMNHPTDAWKEGQFKDIITKVANVELYYKAIQFYLEFKPLLLNDLLMVLSPRLAHTRAVNYFSKVKQLPLVKPYLRSVQNHNNKSVNESLNNLFITEEDYQALRTSIDAYDNFDNISLAQRLEKHELIEFRRIAAYLFKGNNRWKQSVELCKKDSLYKDAMQYASESKDTELAEELLQWFLQEEKRECFGACLFTCYDLLRPDVVLETAWRHNIMDFAMPYFIQVMKEYLTKVDKLDASESLRKEEEQATETQPIVYGQPQLMLTAGPSVAVPPQAPFGYGYTAPPYGQPQPGFGYSM |
| Enzyme Length |
1675 |
| Uniprot Accession Number |
P11442 |
| Absorption |
|
| Active Site |
|
| Activity Regulation |
|
| Binding Site |
|
| Calcium Binding |
|
| catalytic Activity |
|
| DNA Binding |
|
| EC Number |
|
| Enzyme Function |
FUNCTION: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network (By similarity). Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577,PubMed:16968737). The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (By similarity). Plays a role in early autophagosome formation (By similarity). {ECO:0000250|UniProtKB:Q00610, ECO:0000269|PubMed:15858577, ECO:0000269|PubMed:16968737}. |
| Temperature Dependency |
|
| PH Dependency |
|
| Pathway |
|
| nucleotide Binding |
|
| Features |
Beta strand (29); Chain (1); Helix (14); Initiator methionine (1); Modified residue (18); Region (15); Repeat (7); Turn (7) |
| Keywords |
3D-structure;Acetylation;Autophagy;Coated pit;Cytoplasm;Cytoplasmic vesicle;Cytoskeleton;Direct protein sequencing;Membrane;Phosphoprotein;Reference proteome;Repeat |
| Interact With |
Q01968 |
| Induction |
|
| Subcellular Location |
SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Melanosome {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:15858577}. Note=Cytoplasmic face of coated pits and vesicles. In complex with TACC3 and CKAP5 (forming the TACC3/ch-TOG/clathrin complex) localized to inter-microtubule bridges in mitotic spindles. {ECO:0000250|UniProtKB:Q00610}. |
| Modified Residue |
MOD_RES 2; /note=N-acetylalanine; /evidence=ECO:0000269|Ref.2; MOD_RES 67; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:Q00610; MOD_RES 105; /note=Phosphothreonine; /evidence=ECO:0007744|PubMed:22673903; MOD_RES 184; /note=Phosphotyrosine; /evidence=ECO:0000250|UniProtKB:Q68FD5; MOD_RES 394; /note=Phosphothreonine; /evidence=ECO:0007744|PubMed:22673903; MOD_RES 634; /note=Phosphotyrosine; /evidence=ECO:0000250|UniProtKB:Q00610; MOD_RES 737; /note=N6-succinyllysine; /evidence=ECO:0000250|UniProtKB:Q68FD5; MOD_RES 856; /note=N6-acetyllysine; /evidence=ECO:0000250|UniProtKB:Q00610; MOD_RES 899; /note=Phosphotyrosine; /evidence=ECO:0000250|UniProtKB:Q68FD5; MOD_RES 1167; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:Q68FD5; MOD_RES 1206; /note=Phosphotyrosine; /evidence=ECO:0000250|UniProtKB:Q68FD5; MOD_RES 1229; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:Q00610; MOD_RES 1441; /note=N6-acetyllysine; alternate; /evidence=ECO:0000250|UniProtKB:Q00610; MOD_RES 1441; /note=N6-succinyllysine; alternate; /evidence=ECO:0000250|UniProtKB:Q68FD5; MOD_RES 1477; /note=Phosphotyrosine; /evidence=ECO:0000250|UniProtKB:Q00610; MOD_RES 1487; /note=Phosphotyrosine; /evidence=ECO:0000250|UniProtKB:Q68FD5; MOD_RES 1494; /note=Phosphoserine; /evidence=ECO:0007744|PubMed:22673903; MOD_RES 1501; /note=N6-acetyllysine; /evidence=ECO:0000250|UniProtKB:Q00610 |
| Post Translational Modification |
|
| Signal Peptide |
|
| Structure 3D |
X-ray crystallography (3) |
| Cross Reference PDB |
1BPO;
1C9I;
1C9L;
|
| Mapped Pubmed ID |
10336464;
10585476;
10692452;
11102472;
11387476;
11964161;
12213833;
1325974;
1490999;
16396496;
16982422;
16999739;
17065556;
17978091;
19536138;
19562802;
19834914;
19935650;
25427558;
7536412;
|
| Motif |
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| Gene Encoded By |
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| Mass |
191,599 |
| Kinetics |
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| Metal Binding |
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| Rhea ID |
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| Cross Reference Brenda |
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