| IED ID | IndEnz0002018476 |
| Enzyme Type ID | protease018476 |
| Protein Name |
Growth/differentiation factor 5 GDF-5 Bone morphogenetic protein 14 BMP-14 |
| Gene Name | Gdf5 Bmp14 Bp Gdf-5 |
| Organism | Mus musculus (Mouse) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse) |
| Enzyme Sequence | MRLPKLLTLLLWHLAWLDLELICTVLGAPDLGQRTPGAKPGLTKAEAKERPPLARNVFRPGGHIYGVGATNARAKGSSGQTQAKKDEPRKMPPRSGGPETKPGPSSQTRQAAARTVTPKGQLPGGKASSKAGSAPSSFLLKKTREPGTPREPKEPFRPPPITPHEYMLSLYRTLSDADRKGGNSSVKLEAGLANTITSFIDKGQDDRGPAVRKQRYVFDISALEKDGLLGAELRILRKKPLDVAKPAVPSSGRVAQLKLSSCPSGRQPAALLDVRSVPGLDGSGWEVFDIWKLFRNFKNSAQLCLELEAWERGRAVDLRGLGFERTARQVHEKALFLVFGRTKKRDLFFNEIKARSGQDDKTVYEYLFSQRRKRRAPLANRQGKRPSKNLKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISILFIDSANNVVYKQYEDMVVESCGCR |
| Enzyme Length | 495 |
| Uniprot Accession Number | P43027 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Growth factor involved in bone and cartilage formation. During cartilage development regulates differentiation of chondrogenic tissue through two pathways. Firstly, positively regulates differentiation of chondrogenic tissue through its binding of high affinity with BMPR1B and of less affinity with BMPR1A, leading to induction of SMAD1-SMAD5-SMAD8 complex phosphorylation and then SMAD protein signaling transduction (By similarity). Secondly, negatively regulates chondrogenic differentiation through its interaction with NOG (By similarity). Required to prevent excessive muscle loss upon denervation. This function requires SMAD4 and is mediated by phosphorylated SMAD1/5/8 (PubMed:24076600). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (By similarity). {ECO:0000250|UniProtKB:P43026, ECO:0000269|PubMed:24076600}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Compositional bias (2); Disulfide bond (4); Glycosylation (1); Natural variant (1); Propeptide (1); Region (1); Signal peptide (1) |
| Keywords | Cell membrane;Chondrogenesis;Cleavage on pair of basic residues;Cytokine;Disulfide bond;Glycoprotein;Growth factor;Membrane;Reference proteome;Secreted;Signal |
| Interact With | |
| Induction | INDUCTION: Induced over 300-fold in tibialis anterior muscles 3 days following denervation. High expression is maintained at least until 10 days after denervation. {ECO:0000269|PubMed:24076600}. |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P43026}. Cell membrane {ECO:0000250|UniProtKB:P43026}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..27; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 10021340; 10022976; 10036983; 10208739; 10441734; 10631181; 10631182; 11285276; 11398847; 11476582; 11520674; 11702786; 11850178; 11913489; 11969258; 11971015; 11996912; 12413903; 12414734; 12464389; 125666; 12606286; 12805214; 12881039; 12919870; 14516672; 14610273; 14613311; 14660436; 14661262; 14973294; 15102708; 15183306; 15342483; 15371327; 15492776; 15542031; 15719068; 15752764; 15760903; 15769905; 15800003; 15841179; 16015334; 16040801; 1609959; 16109715; 16112556; 16127465; 16495310; 16537572; 16598734; 16602821; 16818445; 16829522; 16962305; 17085896; 17313942; 17317783; 17336282; 17470636; 17576802; 17656374; 17822689; 17913788; 18053235; 18083924; 18096605; 18159948; 18163510; 18339631; 18353862; 18363966; 18406693; 18446812; 18539921; 18729207; 18984342; 19219044; 19235716; 19252479; 19272164; 19273610; 19327734; 19460349; 19604444; 19782107; 19815519; 19909214; 20034107; 20117381; 20206616; 20359476; 20458143; 20660756; 20805298; 20978074; 21185280; 21262216; 21267068; 21278629; 21316585; 21590487; 21750036; 21872590; 21976273; 22019272; 22202776; 22280990; 22365545; 22417325; 22560297; 22682244; 22843502; 22972626; 23313125; 23356643; 2338491; 23475960; 23717575; 23727513; 24062245; 24075990; 24075995; 24098149; 24173804; 24738827; 24944017; 24952961; 24972088; 25078108; 25223801; 25452386; 25527076; 25758226; 25917818; 25926361; 26010756; 26077908; 26097038; 26141957; 26483211; 26542169; 26878848; 26934381; 27030100; 27292641; 27664939; 27713395; 27827819; 27902701; 28169396; 28438606; 28458020; 28819210; 28846100; 29139542; 29146735; 29311146; 29665134; 30225906; 30253032; 30388100; 30635555; 30745426; 30854720; 31066042; 31105007; 31221639; 31553232; 31596513; 31694926; 31932746; 32022343; 3222208; 32580935; 32674056; 33217406; 33347679; 33369147; 33497014; 3569909; 4729943; 4826284; 5949834; 6309591; 6626150; 6732748; 7095270; 744946; 7959780; 7961761; 9012517; 908358; 9603738; 9691180; 9808626; 9885252; |
| Motif | |
| Gene Encoded By | |
| Mass | 54,895 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |