| IED ID | IndEnz0002018480 |
| Enzyme Type ID | protease018480 |
| Protein Name |
Serine protease gd EC 3.4.21.- Protein gastrulation defective |
| Gene Name | gd CG1505 |
| Organism | Drosophila melanogaster (Fruit fly) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Panarthropoda Arthropoda Mandibulata Pancrustacea Hexapoda Insecta Dicondylia Pterygota (winged insects) Neoptera Endopterygota Diptera Brachycera Muscomorpha Eremoneura Cyclorrhapha Schizophora Acalyptratae Ephydroidea Drosophilidae (pomace flies) Drosophilinae Drosophilini Drosophila (fruit flies) Sophophora melanogaster group melanogaster subgroup Drosophila melanogaster (Fruit fly) |
| Enzyme Sequence | MRLHLAAILILCIEHVTKAVAQGMPISPCPKVFQYRFDGSEWFGLMAVRSPDGHQPLHIRVTLSMRGKPTTYTQNYLGEIELLTRGKFTHNAPVLYKIRFPKHHFPPKLLLMSANNHVICFGSGEHSIFMTQIQLEHIRKLSFIPDKKSSLLLDPEEEEVRKTDDKPPSTPHIQFKKKPFAQAPKEICGRIDRDLDFHLSQRTESLHVAIGEPKSSDGITSPVFVDDDEDDVLEHQFVDESEAEAIESDSADSLPSITRGSWPWLAAIYVNNLTSLDFQCGGSLVSARVVISSAHCFKLFNKRYTSNEVLVFLGRHNLKNWNEEGSLAAPVDGIYIHPDFNSQLSSYDADIAVIILKDEVRFNTFIRPACLWSGSSKTEYIVGERGIVIGWSFDRTNRTRDQKLSSELPGKKSTDASAPKVVKAPIVGNAECFRANAHFRSLSSNRTFCAGIQAEERDTHQSGASIYTGISGAGLFIRRNNRWMLRGTVSAALPAVETPDAESSHKLCCKNQYIIYADVAKFLDWITAFVI |
| Enzyme Length | 531 |
| Uniprot Accession Number | O62589 |
| Absorption | |
| Active Site | ACT_SITE 295; /note=Charge relay system; /evidence=ECO:0000255|PROSITE-ProRule:PRU00274; ACT_SITE 350; /note=Charge relay system; /evidence=ECO:0000255|PROSITE-ProRule:PRU00274; ACT_SITE 471; /note=Charge relay system; /evidence=ECO:0000255|PROSITE-ProRule:PRU00274 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.21.- |
| Enzyme Function | FUNCTION: Component of the extracellular signaling pathway that establishes the dorsal-ventral pathway of the embryo (PubMed:9618496, PubMed:9477324, PubMed:12493753). Three proteases; ndl, gd and snk process easter to create active easter (PubMed:9477324). Active easter defines cell identities along the dorsal-ventral continuum by activating the spz ligand for the Tl receptor in the ventral region of the embryo (PubMed:9477324). {ECO:0000269|PubMed:12493753, ECO:0000269|PubMed:9477324, ECO:0000269|PubMed:9618496}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Alternative sequence (3); Chain (1); Compositional bias (1); Disulfide bond (2); Domain (1); Erroneous initiation (2); Glycosylation (3); Mutagenesis (1); Region (1); Sequence caution (1); Signal peptide (1) |
| Keywords | Alternative splicing;Developmental protein;Disulfide bond;Glycoprotein;Hydrolase;Protease;Reference proteome;Secreted;Serine protease;Signal |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:9477324}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..19; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 10072384; 10201075; 10201373; 10449356; 10489372; 10602463; 10625559; 10660298; 10696585; 10731134; 10793472; 10887086; 10903186; 10922064; 10961941; 10980426; 11076773; 11135568; 11283698; 11296245; 11350927; 11413042; 11493599; 11562344; 11606540; 11700289; 11852243; 11923213; 11934858; 12027434; 12091311; 12417410; 12568721; 12653959; 12748300; 1339676; 1425342; 14550796; 14654000; 14711428; 14731500; 15166158; 15199954; 15324670; 15788537; 15840717; 15935780; 15987775; 16166373; 16271864; 16322759; 16537387; 1672778; 16861233; 1688006; 16968133; 17184547; 1733499; 1739964; 1742496; 17996400; 1814368; 18309295; 18477463; 18505835; 1859400; 18776742; 1899484; 19356143; 19442719; 19540119; 20605458; 20638387; 2068782; 20876565; 20970335; 21074052; 22578419; 22611248; 22645339; 22949611; 23015267; 23071443; 23172856; 23632253; 23822503; 23864715; 23868318; 25124754; 25294943; 25312911; 26656493; 26896675; 2703940; 27630034; 27979994; 28305599; 29432195; 30146479; 30367934; 3089870; 3106148; 3129326; 31658274; 32143742; 32157249; 32591083; 32901612; 33795866; 33827210; 3653004; 3931918; 3931919; 405273; 6434989; 7600960; 7635064; 7859742; 7953570; 7958834; 8026333; 8124709; 812739; 8139688; 814037; 8178370; 8196601; 8241766; 8241768; 8698232; 8749385; 8808632; 8825480; 8948598; 8970732; 8987815; 9144922; 9271119; 9407033; 9550723; 9598341; 9600835; 9609827; 9735365; 9827795; 9827800; 9889092; |
| Motif | |
| Gene Encoded By | |
| Mass | 59,477 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |