| IED ID | IndEnz0002018486 |
| Enzyme Type ID | protease018486 |
| Protein Name |
Glutamate carboxypeptidase 2 homolog EC 3.4.17.21 Glutamate carboxypeptidase II homolog |
| Gene Name | gcp-2.1 R57.1 |
| Organism | Caenorhabditis elegans |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Nematoda (roundworms) Chromadorea Rhabditida Rhabditina Rhabditomorpha Rhabditoidea Rhabditidae Peloderinae Caenorhabditis Caenorhabditis elegans |
| Enzyme Sequence | MPYVGVGAQTVSTSLTGAPMVKAYIAIAASLIFVFCIAALGVHHSERKFNKFNKVSIDDIHKSDAGVIQDNIKTENIKKYLRIFTKDPHVAGTEANKKVAYEIANAWSEAGLEDVHTLPYEVLLSYPDFENPNSVIIKSSAGKEVFKSKGVSPVIIPDEQSGKYAGHQWLAYAGNGSASADVVYINHGTANDFKNLKLMGVDIKGKIALMRYGHGFRGDKIHKAQQAGAIGAILFSDTQDVAQDGVESENVYPKKIWMPNEGVQRGSLMHGDGDALSPYYPSKKELFKGRTIEEAKEDGVLPSIPVLPVSYTTGYEILKRLSGRPAPSDWQGFVGGNLTYKLGPGFVNGEKLSINVHSELRTKRIRNVIGYIRGSEEPDSYIMLGNHFDAWVYGSIDPNSGTAVLAEVARAMMQTINETSWKPARTIVFNAWDAEEFGLIGSTEFVEEFVNILQKRAVVYINMDCIQGNISLHVDTVPILEHAVIEASKQVENPSKRERSRGRKTLYDTWMKVFPDKKAGVPKIRVPGGGSDHAPFLNFAGVPVINFTFKNYTTWDTYPLYHTMYETPFSNIHLLDTDNLSVHKAIGQYWAELAKTFADDVILPMNTTHFASVMLKTYLPQLKTTISGINVSRSDFEDIRTQYALLSKSAQDLLTMSKKFQETIHFTQHSFSQNPYDPKHVNAVNERLKSTERCFINPRGVSMHNPSARHVLFSVSDSDSYSSSLMAGVQNAINSYDLNPTKKGLREIINQISIVQYSVICVVNTLRDVI |
| Enzyme Length | 770 |
| Uniprot Accession Number | P91406 |
| Absorption | |
| Active Site | ACT_SITE 435; /note=Nucleophile; /evidence=ECO:0000250|UniProtKB:Q04609 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Release of an unsubstituted, C-terminal glutamyl residue, typically from Ac-Asp-Glu or folylpoly-gamma-glutamates.; EC=3.4.17.21; Evidence={ECO:0000250|UniProtKB:Q04609}; |
| DNA Binding | |
| EC Number | 3.4.17.21 |
| Enzyme Function | |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (1); Alternative sequence (2); Chain (1); Glycosylation (9); Metal binding (6); Region (1); Topological domain (2); Transmembrane (1) |
| Keywords | Alternative splicing;Carboxypeptidase;Glycoprotein;Hydrolase;Membrane;Metal-binding;Metalloprotease;Protease;Reference proteome;Signal-anchor;Transmembrane;Transmembrane helix;Zinc |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 10778742; 21177967; 22267497; 22286215; 22560298; 23800452; 24884423; 25487147; 26876180; 6593563; |
| Motif | |
| Gene Encoded By | |
| Mass | 85,501 |
| Kinetics | |
| Metal Binding | METAL 387; /note=Zinc 1; /evidence=ECO:0000250|UniProtKB:Q04609; METAL 397; /note=Zinc 1; /evidence=ECO:0000250|UniProtKB:Q04609; METAL 397; /note=Zinc 2; /evidence=ECO:0000250|UniProtKB:Q04609; METAL 436; /note=Zinc 2; /evidence=ECO:0000250|UniProtKB:Q04609; METAL 464; /note=Zinc 1; /evidence=ECO:0000250|UniProtKB:Q04609; METAL 562; /note=Zinc 2; /evidence=ECO:0000250|UniProtKB:Q04609 |
| Rhea ID | |
| Cross Reference Brenda |