| IED ID | IndEnz0002018498 |
| Enzyme Type ID | protease018498 |
| Protein Name |
C6 finger domain transcription factor gliZ Gliotoxin production protein Z |
| Gene Name | gliZ AFUA_6G09630 |
| Organism | Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Pezizomycotina leotiomyceta Eurotiomycetes Eurotiomycetidae Eurotiales (green and blue molds) Aspergillaceae Aspergillus Aspergillus subgen. Fumigati Neosartorya fumigata (Aspergillus fumigatus) Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus) |
| Enzyme Sequence | MATAMQDVSPSFTSSPTSTMTTISTTTAATAAAAPKPDKPRKLRSACDACHRSKTRCSGGNPCTRCHEYMSPCTYSYSSRCGKPKGARSRKTLEREQRVAAAAESARIAGNPSALASLPATSTCTSTATTAAAAAAATTTTTIATTTAPSQGPAVDSAAAAAAATTSTVASPRADDCLGLFDDDEESNPFFSSGSENTGGTSFSPDWIPPLPSISDSDLSFPLLESCLGPDHDCNDSLFWSTTAEPDCQPTSKEPLDPRSKLLRSCKCLQTLSSLTARDIRRFDATFVFVRNYARAFSAFYHCSHCPKDAGSISMAVTALQLATTALEKTATAGTDAAGFKSGCSGMTAADLDEDLLTPGAEFFLPANGRGASNPAFQLGSYQIAPLPGEPDLEEHSEILNILIRSAVRRLLAVCWQIWDLLRGPASRDGRGHVFEPYDPSSSSSSSSSSFSSGPEIHQLCDLSCSAEAAQFRSTLVQIPARLCNLLAL |
| Enzyme Length | 489 |
| Uniprot Accession Number | Q4WMK0 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | DNA_BIND 47..73; /note=Zn(2)-C6 fungal-type; /evidence=ECO:0000255|PROSITE-ProRule:PRU00227 |
| EC Number | |
| Enzyme Function | FUNCTION: Transcription factor that regulates gliotoxin production and contributes to virulence (PubMed:15979823, PubMed:17030582, PubMed:20548963, PubMed:21612254). {ECO:0000269|PubMed:17030582, ECO:0000269|PubMed:20548963, ECO:0000269|PubMed:21612254, ECO:0000305|PubMed:15979823}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Compositional bias (1); DNA binding (1); Erroneous initiation (1); Region (3) |
| Keywords | DNA-binding;Metal-binding;Nucleus;Reference proteome;Transcription;Transcription regulation;Virulence;Zinc |
| Interact With | |
| Induction | INDUCTION: Expression is induced by gliotoxin (PubMed:20548963). Expression is controled by veA (PubMed:23087369). Expression is controled by brlA and abaA (PubMed:26032501). Expression is also regulated by rsmA (PubMed:23671611). Expression is also influenced by SfaD and GpgA (PubMed:19915845). {ECO:0000269|PubMed:19915845, ECO:0000269|PubMed:20548963, ECO:0000269|PubMed:23087369, ECO:0000269|PubMed:23671611, ECO:0000269|PubMed:26032501}. |
| Subcellular Location | SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 51,289 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |