| IED ID | IndEnz0002018511 |
| Enzyme Type ID | protease018511 |
| Protein Name |
Glutathione hydrolase 6 EC 3.4.19.13 Gamma-glutamyltransferase 6 GGT 6 EC 2.3.2.2 Gamma-glutamyltranspeptidase 6 Cleaved into: Glutathione hydrolase 6 heavy chain; Glutathione hydrolase 6 light chain |
| Gene Name | Ggt6 |
| Organism | Rattus norvegicus (Rat) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Rattus Rattus norvegicus (Rat) |
| Enzyme Sequence | MDATTGAVLYQKLQLWEPGMESEEEEEEEEIAEPLVLSLRRLQNTPGNKVGGLPGAWTRLLAGLLLLAVSSSLALRQLQGRNSPKGNLGPVDLPASRHSHHPGVYHHSAVISPAATCSRLGQELLVAGGNVVDAGVGAALCLAVVHPHATGLGATFWGLFYNSSSGNSTALTAGPAQILAPGLGLPTALPALHLLHTHFGRLPWSHLLAKPAMLAQKGFEVDAPLASALAAQGTEGLCPLFCHTNGTPLGLGAQVTNPNLAAVLLREALASSPDLVGNALLNLLVRDLGLELPSVQPKPSLEPALQLLLPQGVLFTTPGPSAGPELMGLLESTLHSKTPSPASCSSLLQTAETPVSSALATVDSHGSMLLLTSSLNSSFGSGHLSPSTGVLLSNLEASSVPSTWACPLILRGNLDDTEDDMLGLVASGIPRGAKAMACTLFNHLTTPQTQQQVQHQAQQRPTESPGICGKEALLQVVVHAEHAQVSSIPSGCCPFQGY |
| Enzyme Length | 498 |
| Uniprot Accession Number | Q6IE08 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=an alpha-amino acid + an N-terminal (5-L-glutamyl)-[peptide] = 5-L-glutamyl amino acid + N-terminal L-alpha-aminoacyl-[peptide]; Xref=Rhea:RHEA:23904, Rhea:RHEA-COMP:9780, Rhea:RHEA-COMP:9795, ChEBI:CHEBI:77644, ChEBI:CHEBI:78597, ChEBI:CHEBI:78599, ChEBI:CHEBI:78608; EC=2.3.2.2; CATALYTIC ACTIVITY: Reaction=glutathione + H2O = L-cysteinylglycine + L-glutamate; Xref=Rhea:RHEA:28807, ChEBI:CHEBI:15377, ChEBI:CHEBI:29985, ChEBI:CHEBI:57925, ChEBI:CHEBI:61694; EC=3.4.19.13; CATALYTIC ACTIVITY: Reaction=an S-substituted glutathione + H2O = an S-substituted L-cysteinylglycine + L-glutamate; Xref=Rhea:RHEA:59468, ChEBI:CHEBI:15377, ChEBI:CHEBI:29985, ChEBI:CHEBI:90779, ChEBI:CHEBI:143103; EC=3.4.19.13; |
| DNA Binding | |
| EC Number | 3.4.19.13; 2.3.2.2 |
| Enzyme Function | FUNCTION: Cleaves glutathione conjugates. {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | PATHWAY: Sulfur metabolism; glutathione metabolism. |
| nucleotide Binding | |
| Features | Chain (2); Glycosylation (3); Topological domain (2); Transmembrane (1) |
| Keywords | Acyltransferase;Glutathione biosynthesis;Glycoprotein;Hydrolase;Membrane;Reference proteome;Signal-anchor;Transferase;Transmembrane;Transmembrane helix;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 51,559 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | RHEA:23904; RHEA:28807; RHEA:59468 |
| Cross Reference Brenda |