IED ID | IndEnz0002018512 |
Enzyme Type ID | protease018512 |
Protein Name |
Gilatoxin GTX EC 3.4.21.- Kallikrein-2 |
Gene Name | |
Organism | Heloderma horridum horridum (Mexican beaded lizard) |
Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Sauropsida Sauria (diapsids) Lepidosauria (lepidosaurs) Squamata (squamates) Bifurcata (split-tongued squamates) Unidentata Episquamata Toxicofera Anguimorpha (anguimorph lizards) Neoanguimorpha (New World anguimorph lizards) Helodermatidae (beaded lizards) Heloderma Heloderma horridum (Mexican beaded lizard) Heloderma horridum horridum (Mexican beaded lizard) |
Enzyme Sequence | IIGGQECDETGHPWLALLHRSEGSTCSGVLLNQDWIVTAAHCFYLGELRIGLGVHNRRVLRGNEQVRVSARKKCYPATASIITNSSCSEYTDDIMLIKLDSSVEYTERVRPLSLPTSPASEGAECTVMGWGTTTPPDVTYPAVPVCVRIEMLNNAVCELARDLWNITDSVLCAGTWFGGKDSCKGDSGGPLICRGQLTGIVSWGGFPCEQPLEYGVYTKVISFLFWIQSI |
Enzyme Length | 230 |
Uniprot Accession Number | P43685 |
Absorption | |
Active Site | ACT_SITE 41; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 93; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 187; /note=Charge relay system; /evidence=ECO:0000250 |
Activity Regulation | |
Binding Site | |
Calcium Binding | |
catalytic Activity | |
DNA Binding | |
EC Number | 3.4.21.- |
Enzyme Function | FUNCTION: Has kallikrein-like activity, releases bradykinin from kininogen. Catalyzes the hydrolysis of various arginine ester substrates for trypsin and thrombin and degrades both angiotensin I and II by cleavage of the dipeptide Asp-Arg from the NH2-terminal end. Fibrinogen is also degraded but a fibrin clot is not produced. May have a potentiating effect on potent hemorrhagic toxins present in the venom. {ECO:0000269|PubMed:8408054}. |
Temperature Dependency | |
PH Dependency | |
Pathway | |
nucleotide Binding | |
Features | Active site (3); Chain (1); Disulfide bond (5); Domain (1); Glycosylation (1); Sequence conflict (25) |
Keywords | Direct protein sequencing;Disulfide bond;Glycoprotein;Hydrolase;Protease;Secreted;Serine protease;Toxin |
Interact With | |
Induction | |
Subcellular Location | SUBCELLULAR LOCATION: Secreted. |
Modified Residue | |
Post Translational Modification | PTM: Extensively glycosylated, contains approximately 8 mol of monosaccharide per mol of toxin. {ECO:0000269|PubMed:8408054}. |
Signal Peptide | |
Structure 3D | |
Cross Reference PDB | - |
Mapped Pubmed ID | - |
Motif | |
Gene Encoded By | |
Mass | 25,111 |
Kinetics | |
Metal Binding | |
Rhea ID | |
Cross Reference Brenda |