| IED ID | IndEnz0002018533 |
| Enzyme Type ID | protease018533 |
| Protein Name |
Putative ataxin-3 homolog EC 3.4.19.12 |
| Gene Name | Os01g0851400 LOC_Os01g63250 P0529H11.31 |
| Organism | Oryza sativa subsp. japonica (Rice) |
| Taxonomic Lineage | cellular organisms Eukaryota Viridiplantae Streptophyta Streptophytina Embryophyta Tracheophyta Euphyllophyta Spermatophyta Magnoliopsida Mesangiospermae Liliopsida Petrosaviidae commelinids Poales Poaceae BOP clade Oryzoideae Oryzeae Oryzinae Oryza Oryza sativa (Rice) Oryza sativa subsp. japonica (Rice) |
| Enzyme Sequence | MEEAAAASNGGLLYHEVQEGKLCAVHCVNTTLQGPFFSEFDLSALAVDLDQRERQVMSEGAAGAATTAAGDFLAEGEGSHNVSLGGDFSIQVLQKALEVWDLQVIPLDSPDVGSCLFDPELETAFICHLQDHWFCIRKVNGEWYNFNSLYPAPEHLSKFYLSAFIDTLKGSGWSIFAVRGNFPKECPMATEGSNGFGQWLTPDDARRITSSCNQVQTPTQQAGVSLVADQSEEMSEMDMIAAQQEEADLNAAIAASLMDTGGPFANYAAHEESRSQDAFAIESTSGEMSKDGNLEEQGANKSETSEPNSDNIESASGSNPKQNTTSLEGKESIKED |
| Enzyme Length | 336 |
| Uniprot Accession Number | Q8LQ36 |
| Absorption | |
| Active Site | ACT_SITE 23; /note=Nucleophile; /evidence=ECO:0000255|PROSITE-ProRule:PRU00331; ACT_SITE 132; /note=Proton acceptor; /evidence=ECO:0000255|PROSITE-ProRule:PRU00331; ACT_SITE 147; /evidence=ECO:0000255|PROSITE-ProRule:PRU00331 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; |
| DNA Binding | |
| EC Number | 3.4.19.12 |
| Enzyme Function | FUNCTION: Interacts with key regulators of transcription and represses transcription. Acts as a histone-binding protein that regulates transcription. Acts as a deubiquitinating enzyme (By similarity). {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (1); Compositional bias (1); Domain (2); Region (1) |
| Keywords | Hydrolase;Nucleus;Protease;Reference proteome;Thiol protease;Transcription;Transcription regulation;Ubl conjugation pathway |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 36,205 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |