Detail Information for IndEnz0002018540
IED ID IndEnz0002018540
Enzyme Type ID protease018540
Protein Name Beta-barrel assembly-enhancing protease
EC 3.4.-.-
Gene Name bepA yfgC STM2494
Organism Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic Lineage cellular organisms Bacteria Proteobacteria Gammaproteobacteria Enterobacterales Enterobacteriaceae Salmonella Salmonella enterica (Salmonella choleraesuis) Salmonella enterica I Salmonella typhimurium Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Enzyme Sequence MFRQLKKNLVATLIAALALGQVAPAFADPADTLPDMGTSAGSTLSIGQEMQMGDFYVRQLRGSAPLINDPLLVQYINALGMRLVSHADSVKTPFHFFLINNDEINAFAFFGGNVVLHSALFRYADNESQLASVMAHEISHVTQRHLARAMEDQKRSAPLTWVGALGSILLAMASPQAGMAALTGTLAGTRQGMISFTQQNEQEADRIGIQVLQRAGFDPQAMPSFLEKLLDQARYSTRPPEILLTHPLPESRLADARNRANQMRPVVVQSSADFYFAKARALGMYNSGRNQLTSDLLDQWSKGNVRQQHAAQYGRALQAMEASKYDEARKTLQPLLSAEPNNAWYLDLATDIDLGQKRANDAINRLKNARDLRVNPVLQLNLANAYLQGGQPKAAETILNRYTFSHKDDGNGWDLLAQAEAALNNRDQELAARAESYALAGRLDQAISLLSSASAQAKLGSQQQARYDARIDQLRQLQERFKPYTKM
Enzyme Length 487
Uniprot Accession Number P66950
Absorption
Active Site ACT_SITE 137; /evidence=ECO:0000255|HAMAP-Rule:MF_00997; ACT_SITE 205; /note=Proton donor; /evidence=ECO:0000255|HAMAP-Rule:MF_00997
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number 3.4.-.-
Enzyme Function FUNCTION: Functions as both a chaperone and a metalloprotease. Maintains the integrity of the outer membrane by promoting either the assembly or the elimination of outer membrane proteins, depending on their folding state. {ECO:0000255|HAMAP-Rule:MF_00997}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (2); Chain (1); Metal binding (3); Repeat (2); Signal peptide (1)
Keywords Hydrolase;Metal-binding;Metalloprotease;Periplasm;Protease;Reference proteome;Repeat;Signal;TPR repeat;Zinc
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Periplasm {ECO:0000255|HAMAP-Rule:MF_00997}.
Modified Residue
Post Translational Modification
Signal Peptide SIGNAL 1..27; /evidence=ECO:0000255|HAMAP-Rule:MF_00997
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 53,741
Kinetics
Metal Binding METAL 136; /note=Zinc; catalytic; /evidence=ECO:0000255|HAMAP-Rule:MF_00997; METAL 140; /note=Zinc; catalytic; /evidence=ECO:0000255|HAMAP-Rule:MF_00997; METAL 201; /note=Zinc; catalytic; /evidence=ECO:0000255|HAMAP-Rule:MF_00997
Rhea ID
Cross Reference Brenda