IED ID |
IndEnz0002018548 |
Enzyme Type ID |
protease018548 |
Protein Name |
Alpha-2-macroglobulin
|
Gene Name |
PM0659 |
Organism |
Pasteurella multocida (strain Pm70) |
Taxonomic Lineage |
cellular organisms
Bacteria
Proteobacteria
Gammaproteobacteria
Pasteurellales
Pasteurellaceae
Pasteurella
Pasteurella multocida
Pasteurella multocida subsp. multocida
Pasteurella multocida (strain Pm70)
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Enzyme Sequence |
MNKQYFLSLFSTLAVALTLSGCWDKKQDEANAIQFNVNPIEITNYDETPKEVYPLVISFSGPAAPITSVNKELTQGISIEPALKGKWVWNSDTLLSFKPETDWPTGQDYRVKIDKKILNPQLHYTQKLNEPVVFKTPEFKATLVEQYFHQDPTQAQVRHAIFKLSFTHPVDRQKFEKALQVNLVRKNNDNTQNILSPLKFNVRYGEKDLVAWVNSDNVALAQSDNQYIEVKIDKNLTALLGNNSLETDIISSVKVPTKYSLDFSTGILIAQNEKNEAEQVLHLNFTHSIKGNELEKHISAYLLPEFTPENHPHWRYNLISRDVLQHAVAVPLQRLATETTYANQQSFKLDIPEKRCLYIEVQNKITALGGYEMKGALGDLACAPDYPKYVGFVGKGSILSSIGERKVTIATRNFTKVKLEIGRIQEEQLRHLIALNQGNFQNPDLGQLKIDNIADFFTKNYTLNNKKPQETTYLGIDLEKIVKQAEPAMGIYWLKVTGDSDNPNSTLRDTSQHMDWRNDASNQFSDYRLIVISDLGVIAKKAVDGTQSVFVQSISRGEPVEGATVSVISRNGSIIKSDYTNEQGVVNFSSLAHFKQELAPVMYLVSTQESLSFLPIDKYDRNLDYSRFDVGGIYASENAASLKAYLFNDRGIYRPNETLHTGIITKAQDWQLALNNIPLQFNLYSPSGMLMHKQTIRLEKSGLNSVSFTLPETAETGEWFAELLVTEKNNQTEIGSMTFQVQEFQPDNLKIKTTFNQAHAEGWVAPQDLVATVQLANLFGTPAQNRKVQANLTLQPLLPKFSQYADYRFFDNQRNKSAILYETELNEQVTDKEGKAHFPIDLTQYAENTAQMLYFTADGFENDSGRAVSTVKSVMVSAQPWLIGYQTKNDLAYLKRNTPAVVNFIAVNPKLEKVAVEHLKATLLERKYVSVLTQQASGAYKYESKLIENEIEQTTLQINATGTDFTLNTGKSGDYVLVLSNEHDQEVNRIHYAVIGNQNVSVAMDKNTELKLRLNKKQFKPHEEIEIAIHAPYAGTGLITIESDRVYAHKWFKATTNSSVQRIQLPENFEGTGYVNVQFSRDIHSDDIFTSPLSYGVVPFTVNVDNRRLKLQLDSPKKVKSGETVEFKLSSDKPSKALIYAVNEGILQVAGYQFTDPLSYFFPKYALQVQTAQILDLILPEFSKVMQFAQTGGDADMNMELAMKMAMANMNPFKRKTDKPVAYWSGIVDIHGEKTVSYQIPEEFNGNLKVMAIALSHDGKHLGHVATETLVRNDLILSPTVPLTLTPGDESEINVVIANNTNKAQRVNLKATLEPQLSFIGEAEKVIDIAPMSESRADFVIKATQELGSSTIRFIASYEDAQQQKVDAVRHVTLSVRPIMPKQFATQIQKVAAGKTVTSPLPMTLFPQHRQQSALFSAAPLALAQGVSTYLTHYDNYCTEQMISAAMPMVLFSKNPAYQPLLTALSRKAPQNVGSTGTHDTLEKAFKLLPSRQTEYGNYGIWNNVEEGNLFVTAYVAHFLIEARERHLVLPKAWFGQHGLFNNTISALEEQSVPQEGDSLATLRQRAYSAYLLTRLAKVPSNALLSIRTQLEQQFSAEEWQKDTVSAWLAAAYHMLKQDNEANKLIEPVINQLVAARPAQWTYDAYSDPLIKDSTMLYVIARHFPAQLSKVSDSVLERIVQDLNQQRYNTLSSSMVLLALDAYAQQHQSELANLQIQHQGKEISQSTPLFRFADLADTQMDISFVNNSQQPAWFALSQVGYPQNAAQQALSQGLEVDRSYTDKEGKPIRQVKIGDVIYVTVKIRASTDYVSDVIITDLYPAGFEVLWQQGAEDDFEDSWLAQHTELREDRLLSYLDAEKEMKVLKYQLKAVNIGTFQIPPIYAESMYDRAIKAYSASEGQIKVRK |
Enzyme Length |
1905 |
Uniprot Accession Number |
Q9CMZ1 |
Absorption |
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Active Site |
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Activity Regulation |
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Binding Site |
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Calcium Binding |
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catalytic Activity |
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DNA Binding |
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EC Number |
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Enzyme Function |
FUNCTION: Protects the bacterial cell from host peptidases. {ECO:0000250|UniProtKB:P76578}. |
Temperature Dependency |
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PH Dependency |
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Pathway |
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nucleotide Binding |
|
Features |
Chain (1); Cross-link (1); Lipidation (2); Signal peptide (1) |
Keywords |
Cell membrane;Lipoprotein;Membrane;Palmitate;Protease inhibitor;Reference proteome;Signal;Thioester bond |
Interact With |
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Induction |
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Subcellular Location |
SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|PROSITE-ProRule:PRU00303}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303}. |
Modified Residue |
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Post Translational Modification |
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Signal Peptide |
SIGNAL 1..21; /evidence=ECO:0000255|PROSITE-ProRule:PRU00303 |
Structure 3D |
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Cross Reference PDB |
- |
Mapped Pubmed ID |
- |
Motif |
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Gene Encoded By |
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Mass |
214,429 |
Kinetics |
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Metal Binding |
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Rhea ID |
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Cross Reference Brenda |
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