Detail Information for IndEnz0002018551
IED ID IndEnz0002018551
Enzyme Type ID protease018551
Protein Name Alpha-2-macroglobulin
Gene Name TM_0984
Organism Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)
Taxonomic Lineage cellular organisms Bacteria Thermotogae Thermotogae Thermotogales Thermotogaceae Thermotoga Thermotoga maritima Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)
Enzyme Sequence MGMKRLIFLVFLLISFSLFGGYAYFSRYPVLHPDEGLSFVISDLENITLNVWKISEEDFLKAVFDPESFNFSLLEITRPIYSKKFSSEEWKEFSFPLKDRGFYFATLVSNEGTVFRRVIDRSLFIVTDLEAIYFSDSEKLRLHVFDSDGDFVEGAEVLLFEDSKLIDRVFTGKDGVVSITKHFDTFYIRYGDSRFFGGVYFSGGGLEREKLFFVTDRPIYKPSDTVHFRGQIFSFEEGLYKAFEKTKVTVSIFDTKKNEVYRSEFETDELGGFSGSMKLPDTASVGLYKVNVDHGGRRYYEYFLVEEYRKPEYKVEIETDKDVYISGEVVNYLVRVKYFNGQPVAKAQVAYYVRAFPEEGSGYLVYRGTDFTDEEGNLRLGVKTEEGFQGSYRLEVIVTDESQRQIEETRSVKVYADNVLISPLDRYVSTSPGKQVRVKVKVTDLSGNPLNGLLTTSSEDSTSTVAVENGEAIVTFTPKEPKSYRIELSFGKANTHFYVYAYCGAGTSSEFVINPATNTVKPGDELSVQILAPGKVMGVLGIVSNRVYDTIPVSFTGSVNLRVRIPKDIPEKNLFISFVGLDDNGRIYKLERLNVLLDTNFTTMKILFDKDQYEPGEMAQITIESNVDRVCLFLVDEAIYAMVGAEPPVLENFLYPYMNYPRTRGGFPHYWRLYVSRNSFRNKLASLPEEKTFADFKQNALPSKLNVREYFPDTALWIPSLKLHNGTARVSFKVPDSITSFRATAYGFSKDRFSQTESEMVVSKKFYLMPHLPSFLRESDVIKISATVFNRTSKTLPVQLTVELPENIELLEGSSSRHFLMEANSSHTETWTVKAVSASEGSFVKFVAVGEDLNDAVSMRLPVERFAFEREFYRIMLLDGKETLEIPGQFISSRIRFLDSIVPLVEDSLKRLIDFPYGCVEQTMSRFFPAVVAASAGIEVENLEEIIQRGLFKLYSYQHNDGGWGWFRFGESDDFMTCYVMEGLYFTMKAGYDVAESVLQRGIEYLRKHPSAYGSYVLDLYGVNHEPFKPESEADLVFLSLSSKEALKQLMNYVVQDEQKAYLNVYSNNPLISEIQLNSVFLRALAKWKEFPELERKVTNYLLLKKDSAFWTSTKDTSFVILALLEAMPEYASTTLKVINSENTFELKPGEERSLVPGSLTVSGKGIVEVEVVYIEVPKEAVSEGLEIKREFYKRYELLIEENKMIVDAFVPIGRGYVPRSIHPVEKEQTEELYILPYKYWKKTIEYRGVPLEINGAEVKIKGETYTFFRIETFNGLILVFFRNEALIYDTEKNTITRYLDVTDAGFMRSGPVFLMKGFVLVGDEKIPVPEDVTGLSCTMDEILLRGENKTYWYRNGEFVDLPFVARRVFFWDGKKLVAENIRFSGSSKTLRNRVFEVVFDVGDVKIELGDIIKTVVRVKGDGNYLIVEDFIPSCAQVLSNYREKGIEENKFSYSWYSSWNAWYSGREIRTDRVALFARYLYGNSFDYVWRATAEGVFHLLPARVYPMYSRGLYAHTDPDVLFIGADFIDGRDDQP
Enzyme Length 1536
Uniprot Accession Number Q9X079
Absorption
Active Site
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number
Enzyme Function FUNCTION: Protects the bacterial cell from peptidases. {ECO:0000250|UniProtKB:P76578}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Chain (1); Cross-link (1); Signal peptide (1)
Keywords Protease inhibitor;Reference proteome;Signal;Thioester bond
Interact With
Induction
Subcellular Location
Modified Residue
Post Translational Modification
Signal Peptide SIGNAL 1..23; /evidence=ECO:0000255
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 175,956
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda