| IED ID |
IndEnz0002018551 |
| Enzyme Type ID |
protease018551 |
| Protein Name |
Alpha-2-macroglobulin
|
| Gene Name |
TM_0984 |
| Organism |
Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) |
| Taxonomic Lineage |
cellular organisms
Bacteria
Thermotogae
Thermotogae
Thermotogales
Thermotogaceae
Thermotoga
Thermotoga maritima
Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)
|
| Enzyme Sequence |
MGMKRLIFLVFLLISFSLFGGYAYFSRYPVLHPDEGLSFVISDLENITLNVWKISEEDFLKAVFDPESFNFSLLEITRPIYSKKFSSEEWKEFSFPLKDRGFYFATLVSNEGTVFRRVIDRSLFIVTDLEAIYFSDSEKLRLHVFDSDGDFVEGAEVLLFEDSKLIDRVFTGKDGVVSITKHFDTFYIRYGDSRFFGGVYFSGGGLEREKLFFVTDRPIYKPSDTVHFRGQIFSFEEGLYKAFEKTKVTVSIFDTKKNEVYRSEFETDELGGFSGSMKLPDTASVGLYKVNVDHGGRRYYEYFLVEEYRKPEYKVEIETDKDVYISGEVVNYLVRVKYFNGQPVAKAQVAYYVRAFPEEGSGYLVYRGTDFTDEEGNLRLGVKTEEGFQGSYRLEVIVTDESQRQIEETRSVKVYADNVLISPLDRYVSTSPGKQVRVKVKVTDLSGNPLNGLLTTSSEDSTSTVAVENGEAIVTFTPKEPKSYRIELSFGKANTHFYVYAYCGAGTSSEFVINPATNTVKPGDELSVQILAPGKVMGVLGIVSNRVYDTIPVSFTGSVNLRVRIPKDIPEKNLFISFVGLDDNGRIYKLERLNVLLDTNFTTMKILFDKDQYEPGEMAQITIESNVDRVCLFLVDEAIYAMVGAEPPVLENFLYPYMNYPRTRGGFPHYWRLYVSRNSFRNKLASLPEEKTFADFKQNALPSKLNVREYFPDTALWIPSLKLHNGTARVSFKVPDSITSFRATAYGFSKDRFSQTESEMVVSKKFYLMPHLPSFLRESDVIKISATVFNRTSKTLPVQLTVELPENIELLEGSSSRHFLMEANSSHTETWTVKAVSASEGSFVKFVAVGEDLNDAVSMRLPVERFAFEREFYRIMLLDGKETLEIPGQFISSRIRFLDSIVPLVEDSLKRLIDFPYGCVEQTMSRFFPAVVAASAGIEVENLEEIIQRGLFKLYSYQHNDGGWGWFRFGESDDFMTCYVMEGLYFTMKAGYDVAESVLQRGIEYLRKHPSAYGSYVLDLYGVNHEPFKPESEADLVFLSLSSKEALKQLMNYVVQDEQKAYLNVYSNNPLISEIQLNSVFLRALAKWKEFPELERKVTNYLLLKKDSAFWTSTKDTSFVILALLEAMPEYASTTLKVINSENTFELKPGEERSLVPGSLTVSGKGIVEVEVVYIEVPKEAVSEGLEIKREFYKRYELLIEENKMIVDAFVPIGRGYVPRSIHPVEKEQTEELYILPYKYWKKTIEYRGVPLEINGAEVKIKGETYTFFRIETFNGLILVFFRNEALIYDTEKNTITRYLDVTDAGFMRSGPVFLMKGFVLVGDEKIPVPEDVTGLSCTMDEILLRGENKTYWYRNGEFVDLPFVARRVFFWDGKKLVAENIRFSGSSKTLRNRVFEVVFDVGDVKIELGDIIKTVVRVKGDGNYLIVEDFIPSCAQVLSNYREKGIEENKFSYSWYSSWNAWYSGREIRTDRVALFARYLYGNSFDYVWRATAEGVFHLLPARVYPMYSRGLYAHTDPDVLFIGADFIDGRDDQP |
| Enzyme Length |
1536 |
| Uniprot Accession Number |
Q9X079 |
| Absorption |
|
| Active Site |
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| Activity Regulation |
|
| Binding Site |
|
| Calcium Binding |
|
| catalytic Activity |
|
| DNA Binding |
|
| EC Number |
|
| Enzyme Function |
FUNCTION: Protects the bacterial cell from peptidases. {ECO:0000250|UniProtKB:P76578}. |
| Temperature Dependency |
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| PH Dependency |
|
| Pathway |
|
| nucleotide Binding |
|
| Features |
Chain (1); Cross-link (1); Signal peptide (1) |
| Keywords |
Protease inhibitor;Reference proteome;Signal;Thioester bond |
| Interact With |
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| Induction |
|
| Subcellular Location |
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| Modified Residue |
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| Post Translational Modification |
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| Signal Peptide |
SIGNAL 1..23; /evidence=ECO:0000255 |
| Structure 3D |
|
| Cross Reference PDB |
- |
| Mapped Pubmed ID |
- |
| Motif |
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| Gene Encoded By |
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| Mass |
175,956 |
| Kinetics |
|
| Metal Binding |
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| Rhea ID |
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| Cross Reference Brenda |
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